Usefulness of Technetium-99m Hexamethylpropylene Amine Oxime-Labeled Leukocyte Scintigraphy to Detect Pancreatic Necrosis in Patients with Acute Pancreatitis

Chiaro, Marco Del; Zerbi, Alessandro; Falconi, Massimo; Bertacca, L.; Polese, M.; Sartori, Nora; Boggi, Ugo; Casari, Giorgio; Longoni, Bianca Maria; Salvia, Roberto; Caligo, Maria A.; Carlo, V. Di; Pederzoli, Paolo; Presciuttini, Silvano; Mosca, Franco

doi:10.1159/000108963

Cited by 35 publications

(16 citation statements)

References 58 publications

(24 reference statements)

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“…Others grading systems and laboratory tests have been developed to identify severe acute pancreatitis: the Ranson or Glasgow criteria, the acute physiology and chronic health evaluation II (APACHE II) scoring system, and C-reactive protein levels (CRP) [3,9]. Other imaging techniques with a safer profile than CT, such as magnetic resonance imaging (MRI) and scintigraphy, have also been used to detect severe cases [8,[10][11][12][13]. It has been reported that these imaging techniques are as accurate as CT in diagnosing pancreatic necrosis and staging acute pancreatitis severity, avoiding radiation exposure and iodinated contrast media.…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasound in the staging of acute pancreatitis

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasound in the staging of acute pancreatitis

et al. 2010

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“…A family history of pancreatic cancer in a first-degree relative has consistently been associated with increased risk of pancreatic cancer [1][2][3][4][5][6][7][8][9][10][11]. However, prospective data are limited, and the size of the relative risk associated with a family history of pancreatic cancer has varied substantially across studies.…”

Section: Introductionmentioning

confidence: 99%

“…However, prospective data are limited, and the size of the relative risk associated with a family history of pancreatic cancer has varied substantially across studies. Case-control studies [5][6][7][8][9][10][11] have generally reported higher relative risk estimates than prospective studies [1][2][3][4]. In addition, it is unclear whether the association between a family history of pancreatic cancer and risk of pancreatic cancer varies by age or smoking status, two of the strongest pancreatic cancer risk factors.…”

Section: Introductionmentioning

confidence: 99%

Family history of various cancers and pancreatic cancer mortality in a large cohort

Jacobs

Rodríguez

Newton

et al. 2009

Cancer Causes Control

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A family history of pancreatic cancer is associated with increased risk of pancreatic cancer, but uncertainty remains about the magnitude of this association, whether it varies by age or smoking and whether a family history of other cancers may also be associated with increased risk. We examined family history of 14 cancers and pancreatic cancer mortality among ~1.1 million men and women in Cancer Prevention Study-II (CPS-II). CPS-II participants completed a questionnaire at enrollment in 1982. During follow-up through 2006, there were 7,306 pancreatic cancer deaths. A family history of pancreatic cancer in a parent or sibling was associated with pancreatic cancer mortality [multivariable adjusted rate ratio (RR) = 1.66, 95% confidence interval (CI) 1.43-1.94]. This association was stronger among participants aged under 60 (RR = 2.89, 95% CI 1.67-5.02) than among participants aged 60 or older (RR = 1.61, 95% CI 1.37-1.88). Weaker associations were observed for family history of stomach cancer (RR = 1.23, 95% CI 1.11-1.37), liver cancer (RR = 1.25, 95% CI 1.10-1.43), and colorectal cancer (RR = 1.12, 95% CI 1.01-1.23). Results from this large prospective study indicate family history of pancreatic cancer is associated with a moderate increase in risk of pancreatic cancer, and also identify associations with the family history of certain other cancers which may be useful in generating hypotheses about shared risk factors.

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“…Previous studies in which scintigraphy with radionuclidelabeled leukocytes was used to detect infected pancreatic necrosis were limited to g-camera scintigraphy with leukocytes labeled with 111 In (5,6) or 99m Tc (7)(8)(9)(10). The use of 67 Ga SPECT/CT imaging, with high sensitivity and specificity, was also reported in this clinical context (23).…”

Section: Discussionmentioning

confidence: 99%

“…However, these studies were limited to g-camera scintigraphy with leukocytes labeled with 111 In (5) or 99m Tc (7)(8)(9)(10), and image quality and resolution were unsatisfactory.…”

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confidence: 99%

PET/CT with ¹⁸F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis

et al. 2014

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Early detection of infection in acute pancreatitis (AP) affects the choice of treatment and clinical outcome. We used PET/CT with 18 F-FDGlabeled autologous leukocytes to detect infection in pancreatic or peripancreatic fluid collections in patients with AP. Methods: Fortyone patients (28 men and 13 women) who were 21-69 y old (mean ± SD, 41 ± 11.5) and had AP and radiologic evidence of a fluid collection in or around the pancreas were studied. Leukocytes were separated from the patient's venous blood, labeled with 18 F-FDG, and reinjected intravenously; PET/CT images were acquired 2 h later. A final diagnosis of infection was based on microbiologic culture of fluid aspirated from the collection. Patients were treated with supportive care and antibiotics; percutaneous drainage or laparotomy was performed when indicated. Results: Blood glucose level, total leukocyte count, neutrophil count, and leukocyte labeling efficiency varied from 83 to 212 mg/100 mL (118 ± 30), 4,600 to 24,200/mm 3 (11,648 ± 5,376), 55% to 90% (73 ± 10), and 31% to 97% (81 ± 17), respectively. Increased tracer uptake in the fluid collection was seen in 12 of 41 patients; 10 had culture-proven infection and underwent percutaneous drainage, and aspiration was unsuccessful in 2. The scan results were negative for infection in 29 patients; 25 had fluid culture results that were negative for infection, and aspiration was unsuccessful in 4. The sensitivity, specificity, and accuracy of the scan were all 100% in 35 patients for whom fluid culture reports were available. Conclusion: PET/CT with 18 F-FDG-labeled leukocytes is a noninvasive and reliable method for the diagnosis of infection in pancreatic or peripancreatic fluid collections in patients with AP.

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Usefulness of Technetium-99m Hexamethylpropylene Amine Oxime-Labeled Leukocyte Scintigraphy to Detect Pancreatic Necrosis in Patients with Acute Pancreatitis

Cited by 35 publications

References 58 publications

Contrast-enhanced ultrasound in the staging of acute pancreatitis

Contrast-enhanced ultrasound in the staging of acute pancreatitis

Family history of various cancers and pancreatic cancer mortality in a large cohort

PET/CT with ¹⁸F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis

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Usefulness of Technetium-99m Hexamethylpropylene Amine Oxime-Labeled Leukocyte Scintigraphy to Detect Pancreatic Necrosis in Patients with Acute Pancreatitis

Cited by 35 publications

References 58 publications

Contrast-enhanced ultrasound in the staging of acute pancreatitis

Contrast-enhanced ultrasound in the staging of acute pancreatitis

Family history of various cancers and pancreatic cancer mortality in a large cohort

PET/CT with 18F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis

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Product

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PET/CT with ¹⁸F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis