1992
DOI: 10.1253/jcj.56.95
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Usefulness of Taurine in Chronic Congestive Heart Failure and Its Prospective Application.

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Cited by 139 publications
(71 citation statements)
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“…Thus, these studies have confirmed the clinical usefulness of taurine in CHF. Furthermore, in an attempt to further clarify the effect of taurine on CHF and to define its clinical position as the therapeutic agent for heart failure, we conducted a double-blind comparative study using coenzyme Q10 as a control agent (Azuma et al, 1989;Azuma et al, 1992). In this study a total of 158 patients from 26 hospitals were randomized, and finally 138 patients were divided three treatment groups; daily dose of taurine 3g, taurine 6g and coenzyme Q10 30mg.…”
Section: Clinical Studiesmentioning
confidence: 99%
“…Thus, these studies have confirmed the clinical usefulness of taurine in CHF. Furthermore, in an attempt to further clarify the effect of taurine on CHF and to define its clinical position as the therapeutic agent for heart failure, we conducted a double-blind comparative study using coenzyme Q10 as a control agent (Azuma et al, 1989;Azuma et al, 1992). In this study a total of 158 patients from 26 hospitals were randomized, and finally 138 patients were divided three treatment groups; daily dose of taurine 3g, taurine 6g and coenzyme Q10 30mg.…”
Section: Clinical Studiesmentioning
confidence: 99%
“…212,213 Forty years ago, many Italian clinicians reported that high daily doses of taurine could alleviate coronary angina and intermittent claudication -an effect which conceivably could reflect a decreased tendency of activated leukocytes to clog the microvasculature downstream from stenotic lesions. 214 Taurine supplementation has a safe positive inotropic effect on cardiac function in clinical congestive heart failure, 215,216 has platelet-stabilizing activity complementary to that of aspirin, [217][218][219] and has antihypertensive properties that are well documented in rodent models [220][221][222][223][224] and supported by limited clinical evidence; [225][226][227] these latter effects likely reflect an impact of taurine on calcium flux.…”
Section: Taurine -Physiological Antidote To Hypochlorous Acidmentioning
confidence: 99%
“…Tais efeitos se devem à maior economia cardíaca e ao efeito inotrópico positivo da Tau (8) . O importante efeito positivo na resistência se deve às múltiplas ações bioquímicas da Tau que têm sido descritas tanto em circunstâncias saudáveis, como em situações de deficiência cardía-ca (3,9,10) . Outros autores (11) também investigaram os efeitos metabólicos e cardíacos relacionados com a Tau em atletas e demonstraram que ela previne o aumento da creatina quiinase (CK) e inibe a diminuição das proteínas totais no soro nas primeiras 24 horas após o exercício.…”
Section: Introductionunclassified
“…A Tau exerce efeito protetor quando o coração está sob situações de estresse. Esse aminoácido derivado aumenta a função cardíaca através da regulação da homeostasia intracelular de cálcio (10) . Esse efeito inotrópico é devido ao aumento da taxa de bombeamento e da quantidade de cálcio nas proteínas miofibrilares contráteis.…”
Section: Introductionunclassified