Usefulness of surveillance programmes for early diagnosis of hepatocellular carcinoma in clinical practice

Pascual, Sonia; Irurzun, Javier; Zapater, Pedro; Such, José; Sempere, Laura; Carnicer, Fernando; Palazón, José M.; Iglesia, Pedro de la; Gil, Santiago; España, Francisco; Pérez‐Mateo, Miguel

doi:10.1111/j.1478-3231.2008.01710.x

Cited by 33 publications

(34 citation statements)

References 28 publications

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“…No differences were found in terms of the HCC diagnostic tool used (liver biopsy versus imaging) between the two groups. The HCC diagnosis was achieved through screening programs more frequently in HIV-uninfected than in HIV-infected patients [30,31]. No significant differences among centers concerning screening modality, diagnosis, survival, and HIV status were observed.…”

Section: Hcc Tumor Characteristicsmentioning

confidence: 99%

Hepatocellular Carcinoma in HIV-Infected Patients: Check Early, Treat Hard

et al. 2011

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Section: Hcc Tumor Characteristicsmentioning

confidence: 99%

Hepatocellular Carcinoma in HIV-Infected Patients: Check Early, Treat Hard

et al. 2011

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“…It has been questioned whether screening can improve survival. However, such programs have been shown to be able to detect smaller lesions, and this in turn allows the provision of treatment with curative intent (7,10,29). Consequently, screening indirectly contributes to lessen patient mortality.…”

Section: Discussionmentioning

confidence: 99%

“…However, its epidemiological characteristics, incidence and risk factors vary among different geographical settings (2)(3)(4). Chronic hepatitis B virus (HBV) infection is the main risk factor in Asia and Africa, while in Western countries (including Spain) and in Japan, chronic hepatitis C virus (HCV) infection is the main risk factor for HCC (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Factors related to survival in hepatocellular carcinoma in the geographic area of Sabadell (Catalonia, Spain)

Miquel

Sopeña

Vergara

et al. 2012

Rev. esp. enferm. dig.

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BAckground: hepatocellular carcinoma (HCC) is a very frequent tumor. Screening for the disease is effective, but the prognostic factors are difficult to evaluate.Objectives: 1. To determine epidemiological data and the clinical course of HCC in our setting. 2. To compare patient survival according to whether screening is performed or not. 3. To evaluate survival prognostic factors.Patients and methods: data on the epidemiology and clinical course of patients diagnosed with HCC were collected on a prospective basis (January 2004-December 2006. Two groups were considered according to whether screening had been performed (group A) or not (group B).Results: a total of 110 patients were diagnosed with HCC (70% males). The most common etiology of cirrhosis was hepatitis C (56.1%), and 69% presented mild liver failure (Child-Pugh grade A). The median follow-up was 1.8 years. Fifty-one percent had been subjected to screening. The diagnosis of HCC was established by imaging techniques in 48.2% of the cases, and by histological criteria in 51.8%. The median tumor size was 23 mm in group A and 28 mm in group B (p = 0.005). Treatment with curative intent was provided in 72% of the cases in group A and in 48% in group B (p = 0.011). The median overall survival was 1.99 years -2.67 years in group A and 1.75 years in group B (p = 0.05).The multivariate analysis of overall survival showed the type of treatment (OR = 2.82 95%CI: 1.3-6.12, p = 0.009) and liver function (OR = 1.71 95%CI: 1.1-2.68, p = 0.020) to be independent predictors of survival.Conclusions: screening allows the diagnosis of smaller lesions and a higher percentage of curative treatments. The degree of liver function and the provision of curative treatment are independent predictors of survival.

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“…[12] Thus; persons with HBV infection are 100 times more likely to develop HCC than non-infected persons with annual incidence rates increasing from 0.5% in non cirrhotic patients to 2-6% in cirrhotic patients. [26] Alcohol and HCV infection are of less significance in the aetiology of HCC in Nigeria when compared to western countries.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Hepatocellular Carcinoma in Two Tertiary Hospitals in Nigeria - Has anything Changed?

Okonkwo¹,

Bello²,

Ngim³

et al. 2016

ijSciences

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Usefulness of surveillance programmes for early diagnosis of hepatocellular carcinoma in clinical practice

Abstract: SPs for HCC allow the detection of small tumours and the application of intention-to-cure therapies, which improves survival. However, these programmes do not improve prognosis in patients with advanced cirrhosis.

Cited by 33 publications

References 28 publications

Hepatocellular Carcinoma in HIV-Infected Patients: Check Early, Treat Hard

Hepatocellular Carcinoma in HIV-Infected Patients: Check Early, Treat Hard

Factors related to survival in hepatocellular carcinoma in the geographic area of Sabadell (Catalonia, Spain)

Characteristics of Hepatocellular Carcinoma in Two Tertiary Hospitals in Nigeria - Has anything Changed?

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