Usefulness of Stool Multiplex Polymerase Chain Reaction Assays in Patients with Acute Diarrhea

Kim, Seo Hyun; Kim, You Sun; Kim, Seung Hyuk; Yoon, Won Eui; Myung, Hee Jun; Moon, Jeong Seop; Whang, Dong Hee

doi:10.4166/kjg.2022.011

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Unlike in our study, in a previous study, inflammatory colitis was diagnosed using colonoscopy and imaging, and no tests for microbial pathogens were used. The results may differ because the studies used different definitions of bacterial colitis; however, our study had a larger sample size and used multiple PCR testing for diagnosis, which is more sensitive than culture [ 1 , 21 ]. In a study investigating whether PCT could differentiate between infectious gastroenteritis and inflammatory bowel disease (IBD), PCT and CRP appeared to be good diagnostic markers for gastroenteritis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study

Lee

et al. 2023

JYMS

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Background: Differentiating between bacterial and nonbacterial colitis remains a challenge. We aimed to evaluate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in differentiating between bacterial and nonbacterial colitis.Methods: Adult patients with three or more episodes of watery diarrhea and colitis symptoms within 14 days of a hospital visit were eligible for this study. The patients’ stool pathogen polymerase chain reaction (PCR) testing results, serum PCT levels, and serum CRP levels were analyzed retrospectively. Patients were divided into bacterial and nonbacterial colitis groups according to their PCR. The laboratory data were compared between the two groups. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy.Results: In total, 636 patients were included; 186 in the bacterial colitis group and 450 in the nonbacterial colitis group. In the bacterial colitis group, Clostridium perfringens was the commonest pathogen (n=70), followed by Clostridium difficile toxin B (n=60). The AUC for PCT and CRP was 0.557 and 0.567, respectively, indicating poor discrimination. The sensitivity and specificity for diagnosing bacterial colitis were 54.8% and 52.6% for PCT, and 52.2% and 54.2% for CRP, respectively. Combining PCT and CRP measurements did not increase the discrimination performance (AUC, 0.522; 95% confidence interval, 0.474–0.571). Conclusion: Neither PCT nor CRP helped discriminate bacterial colitis from nonbacterial colitis.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study

Lee

et al. 2023

JYMS

View full text Add to dashboard Cite

show abstract

Usefulness of Stool Multiplex Polymerase Chain Reaction Assays in Patients with Acute Diarrhea

Cited by 1 publication

References 27 publications

Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study

Diagnostic value of serum procalcitonin and C-reactive protein in discriminating between bacterial and nonbacterial colitis: a retrospective study

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