Usefulness of soluble urokinase plasminogen activator receptor (suPAR) as an inflammatory biomarker in obese children

Kösecik, Mustafa; Dervişoğlu, Pınar; Köroğlu, Mehmet; İşgüven, Pınar; Elmas, Bahri; Demiray, Tayfur; Altındiş, Mustafa

doi:10.1016/j.ijcard.2016.11.201

Cited by 7 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean suPAR level in our cohorts was often several-fold higher than levels measured in children with normal weight or obesity, and it was comparable with or higher than in adults who will develop kidney disease. Also, suPAR levels tended to decrease with patient age.…”

Section: Discussionmentioning

confidence: 97%

Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children

et al. 2017

View full text Add to dashboard Cite

show abstract

“…1 ) concentration was in the expected range in the Healthy Control group. 4 , 29 Serum suPAR was not related to either chronic pain alone or obesity alone. However, there was a significant, classic interaction between pain and obesity on suPAR ( P = 0.046) reflected in a significant increase in serum suPAR in the Chronic Pain & Obese group compared to the other 3 groups ( P values shown in Fig.…”

Section: Resultsmentioning

confidence: 88%

“…The 2 studies of which we are aware that measured serum suPAR in adolescents with obesity alone have been conflicting. 4 , 29 More importantly, we are unaware of systematic studies of suPAR in conditions of chronic pain in any age group.…”

Section: Discussionmentioning

confidence: 99%

“… 26 , 32 , 33 , 45 , 54 We are aware of 2 studies evaluating suPAR in children with obesity that showed conflicting results. 4 , 29 We are not aware of systematic studies of the independent effect of chronic pain on suPAR dynamics. Because, as described above, there are significant interactions between obesity and chronic pain in children, the purpose of this study was to perform a preliminary, exploratory study of suPAR in serum samples from a group of male and female adolescents without or with chronic pain and/or obesity that are a subset of a larger, ongoing study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum soluble urokinase plasminogen activator receptor in adolescents: interaction of chronic pain and obesity

Raff

Phillips

Simpson

et al. 2020

PR9

View full text Add to dashboard Cite

show abstract

“…Inflammation is a major contributor to many diseases, and the biological determination of inflammation is of significant benefit in determining the prognosis of the disease. In recent years, YKL-40 and suPAR have been extensively used as inflammatory biomarkers [14,15].…”

Section: Introductionmentioning

confidence: 99%

Western diet induces endogen oxidative deoxyribonucleic acid damage and infl ammation in Wistar rats

Yener

Yerlikaya

2018

Rev. Nutr.

View full text Add to dashboard Cite

Objective Nutritional diseases such as metabolic syndrome, cardiovascular disorder, chronic inflammation or even cancer are observed in people who sustain their lifestyle by Western diet due to high calorie intake. The origin of these diseases are the degraded deoxyribonucleic acid structure. In this study, we investigated whether Western diet produced endogenous oxidative deoxyribonucleic acid damage, apoptosis or inflammation. Methods Twenty-eight male Wistar rats, aged 10-12 weeks, were divided into four groups. The rats in control group received the standard diet and the remaining rats were given one of the following three diets for four weeks: a high-fat diet containing 35% fat, a high-sucrose diet containing 69% sucrose and Western diet comprising both two types of diets. After treatment the serum 8-hydroxy-2-deoxyguanosine, poly (adenosine diphosphate ribose) polymerase-1, chitinase-3-like protein 1, soluble urokinase-type plasminogen activator receptor, Fas ligand and cytochrome c levels were measured. Results It was observed no changes in the serum soluble urokinase-type plasminogen activator receptor, Fas ligand and cytochrome c levels whereas a statistically significant increase in the serum 8-hydroxy-2-deoxyguanosine, poly (adenosine diphosphate ribose) polymerase-1 and chitinase-3-like protein 1 levels were found only in rats that were given Western diet. Conclusion The findings show that Western diet produced endogenous oxidative deoxyribonucleic acid damage, which then increased serum poly (adenosine diphosphate ribose) polymerase-1 levels, eventually leading to inflammation.

show abstract

Usefulness of soluble urokinase plasminogen activator receptor (suPAR) as an inflammatory biomarker in obese children

Cited by 7 publications

References 27 publications

Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children

Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children

Serum soluble urokinase plasminogen activator receptor in adolescents: interaction of chronic pain and obesity

Western diet induces endogen oxidative deoxyribonucleic acid damage and infl ammation in Wistar rats

Contact Info

Product

Resources

About