Usefulness of serum interleukin-18 in predicting cardiovascular mortality in patients with chronic kidney disease – systems and clinical approach

Formanowicz, Dorota; Wanic-Kossowska, Maria; Pawliczak, Elżbieta; Radom, Marcin; Formanowicz, Piotr

doi:10.1038/srep18332

Cited by 46 publications

(45 citation statements)

References 29 publications

(37 reference statements)

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“…IL18 seems to be important indicator and predictor of cardiovascular death in two-year follow-up among non-diabetic patients suffering from chronic kidney disease, with a history of acute myocardial infarction in the previous year. The importance of IL-18 in the process of atherosclerotic plaque formation has been confirmed by systems analysis based on a formal model expressed in the language of Petri nets theory [50].…”

Section: Discussionmentioning

confidence: 88%

The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population

et al. 2020

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Aim It is crucial to identify factors contributing to malnutrition risk in older persons in order to prevent malnutrition as far as possible. Findings Factors that increased the risk of malnutrition were: increased levels of IL-8, osteoprotegerin (OPG), and Soluble-Receptor-For-TNF-alfa (sTNFRII; log transformed). In comparison with previous studies, in our study there was no significant difference in hsCRP and IL-6 in participants at risk of malnutrition and those who were well-nourished, nevertheless, those at risk of malnutrition had significantly higher IL-8, OPG and sTNFRII concentrations, but higher levels of IL-18. Message The etiopathogenesis of malnutrition in older persons is complex and our study indicated that chronic inflammation plays a probable role and should be considered in evaluating nutritional status in the geriatric population; however, it also exposes an avenue where further research is needed in order to enhance our understanding and guide comprehensive patient care.

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Section: Discussionmentioning

confidence: 88%

The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population

et al. 2020

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“…In addition, in one study it was confirmed that young and middleaged patients with a recent AMI have higher IL-18 concentration in serum than age-and sex-matched control subjects, showing that concentration of this cytokine is associated with severity of coronary atherosclerosis [100]. In addition, recent evidence suggests that serum IL-18 is an important indicator and predictor of CV death in two-year follow-up among nondiabetic patients suffering from CKD, with history of AMI in the previous year [101].…”

Section: Renal Biomarkersmentioning

confidence: 73%

Traditional, Nontraditional, and Uremia-Related Threats for Cardiovascular Disease in Chronic Kidney Disease

Rebić¹,

Hamzić-Mehmedbašić²

2018

Chronic Kidney Disease - From Pathophysiology to Clinical Improvements

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As many as 40-50% of all patients suffering from chronic kidney disease (CKD) die from reasons related to cardiovascular disease (CVD). The severity of the illness is directly connected to higher mortality caused by cardiovascular factors, with the cause of the CKD not as significant for the relationship. This risk of high cardiovascular mortality and morbidity is actually so high that it surpasses the risk of the patients reaching end-stage renal disease. Within the context of CKD, CVD has certain distinct characteristics. Left ventricular hypertrophy (LVH) is commonly used as a predictor of cardiovascular (CV) mortality. The striking cardiac interstitial fibrosis, a crucial part of uremic cardiomyopathy, and nonobstructive vascular diseases are highly prevalent CV pathology in CKD patients. Traditional risk factors appear to be of less importance in the CKD population compared to the general population but have been hypothesized as uremic toxins as a risk factor of cardiorenal syndrome. In this chapter, we discuss the importance of renal function in the pathophysiology of heart failure. We also elaborate on the novel understanding of chronic kidney disease and its role in cardiovascular disease progression.

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“…Chiang,et al 13) demonstrated that hemodialysis patients with high levels of IL-18 had a higher probability of hospitalization event during the follow-up period. In another study, Formanowicz, et al 6) found that serum IL-18 concentration was increased in various stages of CKD. IL-18 was found to be superior to well-known cardiovascular risk parameters, such as hs-CRP, carotid intima media thickness, glomerular filtration rate, albumins, ferritin, and N-terminal prohormone of brain natriuretic peptide, in the prognosis of cardiovascular mortality in CKD.…”

Section: Discussionmentioning

confidence: 91%

“…The hemodialysis patients had significant higher levels of IL-18 than healthy controls (701. 6 88.52 versus 152.0 55.31 pg/mL, P < 0.01). Furthermore, SBP, DBP, creatinine, and hs-CRP were significantly higher and LVEF was significantly lower in hemodialysis patients (P < 0.01) than in healthy controls.…”

Section: Demographic and Clinical Characteristics Of Enrolled Particimentioning

confidence: 88%

“…3,4) Previous findings show that inflammatory disorder exists in hemodialysis patients and that serum levels of IL-18 were increased in chronic renal failure and continuous ambulatory peritoneal dialysis patients. 5) Recently, Formanowicz, et al 6) demonstrated that IL-18 predicted cardiovascular mortality in CKD patients. However, it is not known whether IL-18 is a good indicator for predicting MACE in hemodialysis patients.…”

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confidence: 99%

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Interleukin-18

et al. 2018

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A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study. Demographic and clinical data were collected. MACE was used as the primary endpoint. Results showed that the hemodialysis patients had higher levels of IL-18 (701.6 ± 88.52 versus 152.0 ± 55.31 pg/mL, P < 0.01) and a high rate of MACE (15.6% versus 2.5%, P < 0.01) compared with healthy controls. Multiple linear regression analysis showed that the serum creatinine and left ventricular ejection fraction were significantly effective factors influencing IL-18 (P < 0.01). Receiver-operating characteristic curve analysis showed that IL-18 levels were better predictors for MACE. The area under the curve of IL-18 was 0.81 (0.70-0.92) (P = 0.004). IL-18 levels provided 87.5% sensitivity and 26% specificity with a threshold value of 534.5 pg/mL. Our findings indicated that hemodialysis patients with high levels of IL-18 had a high incidence rate of MACE. IL-18 is a good predictive marker of MACE in hemodialysis patients.

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Usefulness of serum interleukin-18 in predicting cardiovascular mortality in patients with chronic kidney disease – systems and clinical approach

Cited by 46 publications

References 29 publications

The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population

The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population

Traditional, Nontraditional, and Uremia-Related Threats for Cardiovascular Disease in Chronic Kidney Disease

Interleukin-18

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