Usefulness of serum des-γ-carboxy prothrombin in detection of hepatocellular carcinoma

Wang, Chaur‐Shine; Lin, Chih–Lin; Lee, Hsi‐Chang; Chen, Kuan-Yang; Chiang, Ming-Feng; Chen, Hung-Sheng; Lin, Tung-Yi; Liao, Li‐Ying

doi:10.3748/wjg.v11.i39.6115

Cited by 82 publications

(51 citation statements)

References 31 publications

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“…Furthermore, AFP elevation in HCC was associated with macrovascular invasion in some studies [38,39] . In the present study, serum AFP levels were correlated with tumor size, which is consistent with the results of previous studies [5,35,36] . There was also a relationship between AFP levels and the tumor number, similar to the other studies [37,40] .…”

Section: Discussionsupporting

confidence: 82%

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Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

İlikhan¹,

Bilici²,

Şahin³

et al. 2015

WJG

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AIM:To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma (HCC). METHODS:Sixty-eight patients with HCC (mean age of 69.1 ± 10.1), 31 cirrhosis patients (mean age of 59.3 ± 6.3) and 33 healthy volunteers (mean age of 51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein (AFP) values with HCC clinicopathological features, such as tumor size, number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion (diameters; ≤ 3 cm, 3-5 cm Prospective Study ORIGINAL ARTICLEand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer (BCLC) criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at -80 ℃ until use. Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay. RESULTS:In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number, presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls (P < 0.001). Prolidase levels were significantly associated with tumor size and number (P < 0.001, P = 0.002, respectively). Prolidase levels also differed in patients in terms of BCLC staging classification (P < 0.001). Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis (P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately (P = 0.032, P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation (r = 0.616; P < 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification, whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels. CONCLUSION:Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. Core tip: Prolidase cleaves dipeptide bonds containing proline, playing a vital role in collagen turnover, matrix remodeling and cell growth. Neoplastic transformation results in deregulation of tissue collagen metabolism, in which metastatic tumor cells produce enhanced amounts of proteases to penetrate basement membranes and the extracellular matrix. Therefore, tumor progression might depend on the breakdown of collagen and other extracellular matrix proteins. The role of prolidase in neoplastic tissues is unknown. Herein, serum prolidase levels in hepatocellular carcinoma (HCC) patients were significantly associated with tumor size and number, Barcelona-clinic liver can...

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Section: Discussionsupporting

confidence: 82%

“…Wang et al [35] and Kasahara et al [36] have also reported a significant relationship between tumor size and serum AFP levels. Furihata et al [37] observed a significant correlation between serum AFP levels and both size and number of HCCs.…”

Section: Discussionmentioning

confidence: 96%

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

İlikhan¹,

Bilici²,

Şahin³

et al. 2015

WJG

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“…For the development of APASL consensus statement for HCC, we performed additional systematic review of studies published from 2003 to August 2008. Summary of recent studies that met the inclusion criteria is shown in Table 1 [160][161][162][163][164][165][166][167][168][169]. The results of the studies that evaluated AFP, DCP, and AFP-L3 were grossly compatible with the previous review.…”

Section: Tumor Markersmentioning

confidence: 52%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

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“…The cut-off levels of markers were set up according to the normal range and previous reports on the relationship between tumor markers and prognosis in HCC. (5,7,8,13,14,26) The number of patients with normal preoperative PIVKA-II levels was less than that of patients with normal AFP level. This finding suggests that AFP level could reflect inflammatory activity associated with chronic hepatitis.…”

Section: Discussionmentioning

confidence: 99%

Tumor Marker Levels Before and After Curative Treatment of Hepatocellular Carcinoma as Predictors of Patient Survival

et al. 2011

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Abstract-fetoprotein (AFP) is used as a marker for hepatocellular carcinoma (HCC), which is influenced by hepatitis. Protein induced vitamin K absence or antagonist II (PIVKA-II) is a sensitive diagnostic marker. Changes in these markers after treatment may reflect curability and predict outcome. We conducted an analysis of prognosis in 470 HCC patients who received curative treatments, and examined relationship between changes in AFP and PIVKA-II levels after 1-month of treatment in 156 patients. Subjects were divided into three groups according to changes in both levels: 1) normal (L) group before treatment, 2) normalization (N) or 3) decreased but still above normal level or unchanged (ANU) group after treatment. High AFP and PIVKA-II levels were significantly associated with poor tumor-free and overall survival. Presence of large size and advanced stage were significantly associated with prevalence of DU group. Overall survival in the AFP-L group was significantly better than those of other groups and overall survival in PIVKA-II-L and N groups were significantly better than those of PIVKA-II-ANU groups. Combination of changes in AFP-ANU and PIVKA-II-ANU group showed the worst tumor-free and overall survivals. Multivariate analysis identified high pre-treatment levels of AFP and PIVKA-II and combination of AFP-ANU and PIVKA-II-ANU as significant determinants of poor tumor-free and overall survival, particularly in patients who underwent hepatectomy. We conclude that high levels of AFP or PIVKA-II after treatment for HCC did not sufficiently reflect curative efficacy of treatment and reflected a poor predictor of prognosis in HCC patients. Nanashima et al., Page 3

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Usefulness of serum des-γ-carboxy prothrombin in detection of hepatocellular carcinoma

Abstract: Our study indicates that DCP has a better diagnostic value than AFP in differentiating HCC from nonmalignant chronic liver disease. DCP has not only a stronger correlation with HCC than AFP in tumor size but also more effectiveness than AFP in detecting small size of HCC.

Cited by 82 publications

References 31 publications

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Tumor Marker Levels Before and After Curative Treatment of Hepatocellular Carcinoma as Predictors of Patient Survival

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