Usefulness of serum amylase and lipase as predictors of the severity of post-endoscopic retrograde cholangiopancreatography pancreatitis

Abstract

Background: Post-ERCP pancreatitis (PEP) is the most common complication of Post-endoscopic retrograde cholangiopancreatography. Objective:The objective of the study was to demonstrate whether serum amylase and lipase values correlate with the presence and severity of PEP. Methods: We conducted a retrospective, observational, and analytical study of patients who underwent ERCP, those who developed pancreatitis were classified by severity according to the 2012 revised Atlanta criteria and their serum enzyme levels were analyzed. We used ROC (Receiver Operating Characteristics) curves to know the best enzyme cutoff points and analyzed their diagnostic yields. Chi-square, t-distribution, and Mann-Whitney U test were used in the variable analysis and it was considered statistically significant when p < 0.05. Results: A total 621 patients, 54 presented pancreatitis. For moderately severe and severe forms: lipase level of 1500 U/L had an area under the curve (AUC) = 0.827, 95% CI (0.

T‑tube versus internal drainage tube in laparoscopic common bile duct exploration

“…A total of 12 patients had a slight increase in blood amylase after the operation, which may be associated with the catheter indwelling in the duodenal papilla. Transient elevation of blood amylase is a common problem after ERCP surgery, which may be associated with obstruction of the pancreatic duct caused by spasm of the Oddi's sphincter, and generally does not cause any serious complications (15). Surgical indications should be well understood for the use of the internal drainage tube.…”