Usefulness of seasonal malaria chemoprevention in the Sahel

Kalenda, Nadine Kayiba; Tshibangu‐Kabamba, Evariste; Nakagama, Yu; Kaku, Natsuko; Kaneko, Akira; Speybroeck, Niko; Kido, Yasutoshi

doi:10.1016/s1473-3099(22)00654-5

Cited by 2 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the perceived usefulness of these interventions, further implementation of S-P-based chemoprevention raises some concerns that should be brought to the attention of DRC health authorities. First, the risk of further selecting PfDHPS K540E parasites and quintuple IRN-GE mutants should be managed properly and closely monitored to avoid rapidly reaching higher resistance levels and complete loss of the clinical e cacy of the drug [70,[74][75][76]. Second, combining S-P with amodiaquine, which has shown its effectiveness in the Sahel subregion of Africa [77], should be considered instead of simply the S-P combination.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malaria drug resistance landscape in the Democratic Republic of the Congo: a spatial mapping systematic review of molecular surveillance surveys

Kalenda

Tshibangu‐Kabamba²,

Kido³

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Context: The Democratic Republic of Congo (DRC), one of the most malaria-affected countries worldwide, is a potential hub for global drug-resistant malaria. This study aimed at summarizing and mapping surveillance surveys of malaria parasites carrying molecular markers of drug-resistance across the country. Methods: A systematic mapping review was carried out before July 2023 by searching for relevant articles through seven databases (PubMed, Embase, Scopus, African Journal Online, African Index Medicus, Bioline and Web of Science). Results: We identified 1541 primary studies of which 29 fulfilled inclusion criteria and provided information related to 6385 Plasmodium falciparumclinical isolates (collected from 2000 to 2020). We noted the PfCRT K76T mutation encoding for chloroquine-resistance in median 32.1% [interquartile interval, IQR: 45.2] of analyzed malaria parasites. The proportion of parasites carrying this mutation decreased overtime but wide geographic variations persisted. A single isolate had encoded the PfK13 R561H substitution that is invoked in artemisinin-resistance emergence in the Great Lakes region of Africa. Parasites carrying various mutations linked to resistance to the sulfadoxine-pyrimethamine combination were widespread and reflected a moderate resistance profile (PfDHPS A437G: 99.5% [IQR: 3.9]; PfDHPS K540E: 38.9% [IQR: 47.7]) with median 13.1% [IQR: 10.3] of them being quintuple IRN-GE mutants (i.e., parasites carrying the PfDHFR N51I-C59R-S108Nand PfDHPS A437G-K540E mutations). These quintuple mutants tended to prevail in eastern regions of the country. Among circulating parasites, we did not record any parasites harboring mutations related to mefloquine-resistance, but we could suspect those with decreased susceptibility to quinine, amodiaquine, and lumefantrine based on corresponding molecular surrogates. Conclusion: Drug resistance poses a serious threat to existing malaria therapies and chemoprevention options in the DRC. This review provides a baseline for monitoring public health efforts as well as evidences for decision-making in support of national malaria policies and for implementing regionally tailored control measures across the country.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Finally, given the regional genetic background, local evidence (e.g. provided by clinical trials) of the prophylactic e cacy and the sustainability of any S-P based strategy is needed [69, 74,78].…”

Section: Discussionmentioning

confidence: 99%

Malaria drug resistance landscape in the Democratic Republic of the Congo: a spatial mapping systematic review of molecular surveillance surveys

Kalenda

Tshibangu‐Kabamba²,

Kido³

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

The landscape of drug resistance in Plasmodium falciparum malaria in the Democratic Republic of Congo: a mapping systematic review

Kayiba,

Tshibangu-Kabamba,

Rosas-Aguirre

et al. 2023

Trop Med Health

View full text Add to dashboard Cite

Context The Democratic Republic of Congo (DRC), one of the most malaria-affected countries worldwide, is a potential hub for global drug-resistant malaria. This study aimed at summarizing and mapping surveys of malaria parasites carrying molecular markers of drug-resistance across the country. Methods A systematic mapping review was carried out before July 2023 by searching for relevant articles through seven databases (PubMed, Embase, Scopus, African Journal Online, African Index Medicus, Bioline and Web of Science). Results We identified 1541 primary studies of which 29 fulfilled inclusion criteria and provided information related to 6385 Plasmodium falciparum clinical isolates (collected from 2000 to 2020). We noted the PfCRT K76T mutation encoding for chloroquine-resistance in median 32.1% [interquartile interval, IQR: 45.2] of analyzed malaria parasites. The proportion of parasites carrying this mutation decreased overtime, but wide geographic variations persisted. A single isolate had encoded the PfK13 R561H substitution that is invoked in artemisinin-resistance emergence in the Great Lakes region of Africa. Parasites carrying various mutations linked to resistance to the sulfadoxine–pyrimethamine combination were widespread and reflected a moderate resistance profile (PfDHPS A437G: 99.5% [IQR: 3.9]; PfDHPS K540E: 38.9% [IQR: 47.7]) with median 13.1% [IQR: 10.3] of them being quintuple IRN–GE mutants (i.e., parasites carrying the PfDHFR N51I–C59R–S108N and PfDHPS A437G–K540E mutations). These quintuple mutants tended to prevail in eastern regions of the country. Among circulating parasites, we did not record any parasites harboring mutations related to mefloquine-resistance, but we could suspect those with decreased susceptibility to quinine, amodiaquine, and lumefantrine based on corresponding molecular surrogates. Conclusions Drug resistance poses a serious threat to existing malaria therapies and chemoprevention options in the DRC. This review provides a baseline for monitoring public health efforts as well as evidence for decision-making in support of national malaria policies and for implementing regionally tailored control measures across the country.

show abstract

Usefulness of seasonal malaria chemoprevention in the Sahel

Cited by 2 publications

References 7 publications

Malaria drug resistance landscape in the Democratic Republic of the Congo: a spatial mapping systematic review of molecular surveillance surveys

Malaria drug resistance landscape in the Democratic Republic of the Congo: a spatial mapping systematic review of molecular surveillance surveys

The landscape of drug resistance in Plasmodium falciparum malaria in the Democratic Republic of Congo: a mapping systematic review

Contact Info

Product

Resources

About