Usefulness of Red Cell Distribution Width to Predict Mortality in Patients With Peripheral Artery Disease

Ye, Zi; Smith, Carin Y.; Kullo, Iftikhar J.

doi:10.1016/j.amjcard.2010.12.023

Cited by 177 publications

(155 citation statements)

References 31 publications

(27 reference statements)

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“…Ye et al found a 10% greater risk of mortality for a 1% increase in RDW for patients with peripheral arterial disease (23). Gonçalves et al showed that RDW was associated with higher in-hospital mortality and was an independent predictor of in hospital major bleeding in a population of patients with non-ST elevation acute coronary syndromes (8).…”

Section: █ Resultsmentioning

confidence: 99%

The relationship of hematoma growth to rdw in patients with hypertensive intracerebral hemorrhage

Altintas¹,

Dürüyen²,

Baran³

et al. 2015

Turkish Neurosurgery

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Hypertension is still the main cause, being responsible for approximately 55% of cases of ICH (3). Early hematoma growth occurs in 20%-40% of ICH patients and is a major determinant of early deterioration and poor clinical outcome (12,13).Red cell distribution width (RDW) and platelet distribution width (PDW) are markers of variation of the size of the circulating red █ INTRODUCTION I ntracerebral hemorrhage (ICH) is a subtype of stroke with morbidity and mortality accounting for about 15% of all deaths from stroke (12,13). The prevalence of ICH risk factors including older age, hypertension, diabetes mellitus and obesity are increasing, and case fatality remains high with an overall rate of 40% at 1 month (3,9,12,13,19,21).AIm: Hypertension is a primary risk factor for intracerebral hemorrhage (ICH) and is thought to be responsible for about 55% of all ICH cases. Thus, the primary goal of the study was to examine whether the status of vascular rheological factors upon admission to the hospital was associated with hypertensive ICH growth and early outcomes. mATERIAl and mEThODS: Over a 2-year period, the present study evaluated 60 ICH patients who were admitted within the first 12 hours of symptom onset. Brain computed tomography scans were performed at admission and then 24 hours later as a control. Hematoma growth was classified as an volume increase more than 6.5 ml or >33%, and good outcome was defined using the modified Rankin Scale (mRS) score (≤ 2 at 3 months). RESUlTS:The mean age of the study population was 65.07 ± 11.659 years, with 34 men and 26 women. The leading vascular risk factor was hypertension (86.7%). There were significant associations between the initial red blood cell distribution width (RDW) and hematoma growth (p=0.038). Therefore, hematoma growth in the first 24 hours after symptom onset was significantly related to a poor clinical outcome at 3 months (p = 0.050). CONClUSION:The study identified significant relationships between the initial RDW and poor outcome as well as the initial RDW and hypertensive hematoma growth. Additionally, this study demonstrated that these parameters are easily obtainable and could be used to effectively evaluate outcomes in ICH patients.

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Section: █ Resultsmentioning

confidence: 99%

The relationship of hematoma growth to rdw in patients with hypertensive intracerebral hemorrhage

Altintas¹,

Dürüyen²,

Baran³

et al. 2015

Turkish Neurosurgery

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“…the risk assessment and determination of prognosis in patients with coronary artery disease, hypertension, HF, acute coronary syndrome, stroke, and peripheral arterial disease, and in patients undergoing coronary artery bypass surgery [1][2][3][6][7][8][9][10][11].…”

Section: Conflict Of Interest: None Declaredmentioning

confidence: 99%

Raised red cell distribution width as a prognostic marker in aortic valve replacement surgery

et al. 2016

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A b s t r a c t Background and aim:Several studies have reported that elevated red cell distribution width (RDW) is associated with poor outcomes in patients with coronary artery disease, chronic heart failure and aortic stenosis following transcatheter aortic valve replacement. Their prognostic utility in patients undergoing aortic valve replacement (AVR) surgery is unknown. Methods:We prospectively evaluated the prognostic value of RDW in a group of 191 consecutive patients with severe symptomatic aortic stenosis undergoing AVR. The pre-defined primary endpoint at the 30-day follow-up was composed of: all cause mortality, perioperative myocardial infarction, perioperative renal failure, prolonged mechanical ventilation, stroke, heart failure, successfully resuscitated cardiac arrest, the occurrence of multiple-organ failure, and the need for additional surgery for any reason. The secondary endpoint was total mortality. In multivariate analysis, RDW (OR 3.274;; p = 0.0003) and RBC (OR 0.373; 95% CI 0.176-0.787; p = 0.0097) remained independent predictors of the composite endpoint. Receiver operating characteristic analysis determined a cut-off value of RDW for the prediction of the occurrence of the combined endpoint at 14.1%. Conclusions:Elevated RDW is associated with a worse outcome following AVR, independent of RBC.

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“…Originally it is used to distinguish types of anemia. However, it has been recently demonstrated that an increase in the RDW values may be associated with heart failure, coronary ar tery disease or peripheral artery disease [1][2][3][4]. Moreover, RDW is believed to be an indicator of inflammation as well, since an increase in this value might be a result of oxidative stress on the erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

Could Red Cell Distribution Width Serve as a New Inflammatory Marker in Coronary Artery Bypass Grafting?

2014

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Aim. In our study, we researched whether on-pump and off-pump coronary artery bypass grafting (CABG) differ as regards their effect on postoperative red cell distribution width (RDW). Moreover, we also investigated whether there was a link between the preoperative and postoperative RDW levels and the early adverse events after CABG. Material and methods. In this study there were 127 consecutive patients who had previously undergone CABG. The patients were divided as group 1 (off-pump, n: 49) and group 2 (on-pump, n: 78). The hemogram and biochemistry panel values were measured a day before the operation, on the first, third and seventh days after it, and in the postoperative first and sixth months. Results. The statistically significant values detected in the hemogram were as follows: postoperative first day hemoglobin, postoperative first day leukocyte, postoperative first day thrombocyte, postoperative first day C-reactive protein, postoperative third day RDW, postoperative third day leukocyte, postoperative seventh day RDW, postoperative seventh day leukocyte, postoperative first month RDW, and postoperative first month thrombocyte (p<0,05). It was found in multivariate analysis that preoperative RDW is an independent risk factor for plasma used in the postoperative period (odds ratio: 0.552; 95% CI: 0.346-0.879; P=0.012). There was no link between preoperative RDW and other early adverse events in the postoperative period (p>0,05). Conclusion. We found that on-pump CABG increases the RDW levels more in the acute period, when compared with off-pump surgery, but that this effect disappears by the sixth month after the operation. For this reason, RDW can be used as a new inflammatory marker in patients undergoing CABG. Moreover, we observed that there was no clinical link between early adverse events after CABG and the pre-and postoperative RDW levels.Russ J Cardiol 2014, 7 (111), Engl.: 5-11

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Usefulness of Red Cell Distribution Width to Predict Mortality in Patients With Peripheral Artery Disease

Cited by 177 publications

References 31 publications

The relationship of hematoma growth to rdw in patients with hypertensive intracerebral hemorrhage

The relationship of hematoma growth to rdw in patients with hypertensive intracerebral hemorrhage

Raised red cell distribution width as a prognostic marker in aortic valve replacement surgery

Could Red Cell Distribution Width Serve as a New Inflammatory Marker in Coronary Artery Bypass Grafting?

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