Usefulness of protein analysis for detecting pathologies in bone remains

Pérez-Martínez, Cristina; Prieto-Bonete, Gemma; Pérez-Cárceles, María D.; Luna, Aurelio

doi:10.1016/j.forsciint.2015.11.009

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…Forensic anthropological investigations have been solving human remains mysteries since the 19th century, with early pioneers developing methodologies that focused on anatomy and physical anthropology to solve crimes [ 1 ]. Subsequent technological innovations have revolutionized forensic investigation, and the field of forensic science has progressed with key discoveries facilitating ultrasensitive DNA [ 2 , 3 ] and protein [ 4 ] recovery from skeletal remains and surfaces. Because of these breakthroughs, 21st century forensics has the ability to answer biological and legal questions with remarkable accuracy and precision.…”

Section: Main Text Introductionmentioning

confidence: 99%

Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Schwabenlander,

Bartz,

Carstensen

et al. 2024

Prion

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Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer ( Odocoileus virginianus ) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.

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Section: Main Text Introductionmentioning

confidence: 99%

Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Schwabenlander,

Bartz,

Carstensen

et al. 2024

Prion

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“…Indeed, a recent study was able to use protein analysis to identify the presence of pathology biomarkers in the bone (Pérez-Martínez et al 2016).…”

Section: Archaeoproteomic Analysismentioning

confidence: 99%

Experimental immunology and the potential for osteopathological reconstructions : pursuing an experimental foundation for the skeletal inflammatory index.

Duncanson¹

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for their friendship in lab, as well as their contributions to the raw data used for this thesis. To Dr. Kathryn Marklein for her review of my work, encouragement, and support. To Dr. Rachel Neal for my time spent in her lab, her years of mentorship, and her invaluable assistance in reviewing my statistical analyses. To the University of Louisville Department of Anthropology for the education and countless opportunities during my time as both an undergraduate and graduate student. I would especially like to express my deep gratitude and appreciation for the members of my thesis committee. To Dr. Haagen Klaus, for mentorship, encouragement, and the inspiration gleaned from his work. To Dr. Christopher Tillquist, for the years of education as a student, and as a teaching assistant, and for continuous lessons in critical thinking. To Dr. Fabián Crespo, my advisor, for the years of mentorship and opportunities, and the introduction to the potentials of both immunology and anthropology. Finally, I would like to express my gratitude to my husband Robert Duncanson for his unwavering, and unconditional support, for all my academic pursuits.

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Cancer

Marques

2022

Bone Cancer

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Usefulness of protein analysis for detecting pathologies in bone remains

Cited by 7 publications

References 34 publications

Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Experimental immunology and the potential for osteopathological reconstructions : pursuing an experimental foundation for the skeletal inflammatory index.

Cancer

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