Usefulness of presepsin (sCD14 subtype) measurements as a new marker for the diagnosis and prediction of disease severity of sepsis in the Korean population

Kweon, Oh Joo; Choi, Jee‐Hye; Park, Sang Kil; Park, Ae Ja

doi:10.1016/j.jcrc.2014.06.014

Cited by 83 publications

(85 citation statements)

References 13 publications

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“…On the other hand, PCT tend to perform better than CRP in differentiating between septic and non-septic patients. It has been previously reported that CRP showed a higher sensitivity than presepsin and PCT, whereas, in accordance with our findings, CRP exhibited a lower specificity than presepsin and PCT, in diagnosing infection, with AUCs indicating that presepsin is superior to PCT and CRP in diagnosing sepsis [20]. In agreement with our results, in a more recent study, presepsin showed a higher sensitivity than PCT and CRP for diagnosing sepsis in patients with SIRS, with AUCs suggesting that presepsin tend to perform better than PCT and CRP in diagnosing sepsis.…”

Section: Discussionsupporting

confidence: 92%

“…In contrast, CRP levels did not differ between the first and the third day, whereas there was a significant decrease in CRP level at the seventh day. Also, it has been showed that presepsin and PCT levels decreased more rapidly than CRP levels during treatment [20]. The real reason that the time course of presepsin differs from those of PCT and CRP is not clear.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the APACHE II score on admission were significantly higher in non-survivors than in survivors (mean ± SD, 17.9 ± 4.9 [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] vs. 13.6 ± 3 [10][11][12][13][14][15][16][17][18][19], P = 0.007). All septic patients were followed-up for 28 days after enrollment in the study, and the performance of presepsin, PCT, CRP and APACHE II score for predicting 28-day all-cause in-hospital mortality was evaluated by ROC curve analysis in the surviving versus non-surviving groups ( Table 4, Fig.…”

Section: Prognostic Value Of Presepsin Pct Crp and Apache II Scorementioning

confidence: 99%

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Presepsin is an early monitoring biomarker for predicting clinical outcome in patients with sepsis

Ali

Elnakeeb

et al. 2016

Clinica Chimica Acta

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Prognostic Value Of Presepsin Pct Crp and Apache II Scorementioning

confidence: 99%

See 1 more Smart Citation

Presepsin is an early monitoring biomarker for predicting clinical outcome in patients with sepsis

Ali

Elnakeeb

et al. 2016

Clinica Chimica Acta

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“…[1] CD14, a cluster differentiation (CD) marker protein, is a multifunctional cell surface glycoprotein, which exists as a membrane-anchored form or in a circulating soluble form. [9] The circulating soluble form of CD14 subtype (sCD14-ST), presepsin, is mainly used in acute care settings, such as emergency department and critical care, to distinguish between sepsis and systemic inflammatory response syndrome (SIRS) and for early detection of a possible bacterial cause.…”

Section: Late-onset Neonatal Sepsis (Los) Is a Life-threatening Condimentioning

confidence: 99%

Presepsin as an Early Reliable Diagnostic and Prognostic Marker of Neonatal Sepsis.

Sabry¹,

Elfeky²,

Elsadek³

et al. 2016

IJAR

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Background:-Sepsis is a common cause of morbidity and mortality among neonates, and current biomarkers for diagnosis are not adequate. The objective of the study was to assess the diagnostic and prognostic value of presepsin.Methods:-One hundred and twenty neonates were enrolled in the study; 80 cases and 40 controls. Presepsin and CRP levels were measured during 1st, 2nd& 6th days of admission for cases while were measured once for each control.Results:-Initial presepsin levels were significantly higher in group produced neonatal sepsis than in the non-septic group. At a cut off value ≥ 0.722 µg/L, Presepsin sensitivity for prediction of neonatal sepsis was 100 %, specificity 97.5%, positive predictive value (PPV) 98.7%, negative predictive value (NPV) 100%, area under curve (AUC) 0.99 with high sensitive positive correlation with sepsis (P value < 0.001). At a cut off value < 2.3 µg/L, Its prognostic sensitivity was 75.9%, specificity 72.5%, PPV 61.1, NPV 84.1 and AUC 0.76. Conclusion:-Presepsin sensitivity for early diagnosis of neonatal sepsis was 100 % with specificity 97.5%. Presepsin is an accurate biomarker for early diagnosis of neonatal sepsis. It also provides a useful tool for prediction of improving.Copy Right, IJAR, 2016,. All rights reserved.

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“…During inflammation, plasma protease activity generates soluble CD14 fragments (Henriquez-Camacho & Losa, 2014). One of them, the circulating soluble form of CD14 subtype (sCD14-ST) or presepsin, increases in response to bacterial infections and is considered a new, emerging, early marker for sepsis (Chenevier-Gobeaux et al, 2015), capable of predicting bacteraemia (Kweon et al, 2014;Rabensteiner et al, 2014;Romualdo et al, 2014;Shozushima et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of presepsin (sCD14-ST) and procalcitonin for prediction of bacteraemia and bacterial DNAaemia in patients with suspected sepsis

Leli

Ferranti

Marrano

et al. 2016

Journal of Medical Microbiology

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Early diagnosis and prompt targeted therapy are essential for septic patients' outcome. Procalcitonin (PCT) has been shown to predict bacteraemia and bacterial DNAaemia. Presepsin, the circulating soluble form of CD14 subtype, increases in response to bacterial infections, and is considered a new, emerging, early marker for sepsis. We evaluated the diagnostic accuracy of presepsin in predicting bacteraemia and bacterial DNAaemia in 92 patients with suspected sepsis, and we compared it with that of PCT and C-reactive protein (CRP). Presepsin median values were significantly higher in bacteraemic vs non-bacteraemic patients [1290 pg ml .07, respectively). Both biomarkers performed significantly better than CRP, which had an AUC for bacteraemia of 0.602 and for DNAaemia of 0.632 (all P values <0.05). In conclusion, in patients with suspected sepsis, presepsin and PCT showed a good diagnostic accuracy in predicting both bacteraemia and bacterial DNAaemia, superior to CRP. INTRODUCTIONSepsis, a systemic deleterious host response to infection that leads to organ dysfunction (Dellinger et al., 2013), is a major cause of morbidity and mortality (Mayr et al., 2014). Early diagnosis and prompt targeted therapy are essential for patients' outcome (Kumar et al., 2006).Blood culture (BC) is the gold standard for pathogen detection, although false-negative results, especially in antibiotic pre-treated patients, can occur (Opota et al., 2015). New approaches to speed sepsis diagnosis include molecular assays and the use of specific biomarkers (Reinhart et al., 2012). Molecular technologies, allowing a rapid detection of microbial DNA, could represent an important additional tool for the aetiological diagnosis of bloodstream infections, particularly in antibiotic pre-treated patients (Dark et al., 2015;Mongelli et al., 2015;Pasqualini et al., 2012). Indeed, real-time PCR (RT-PCR) can detect not only viable microorganisms in patient's blood (bacteraemia) but also circulating bacterial DNA (DNAaemia) that persists for several days in blood during antimicrobial treatment or may be released into the bloodstream from the primary infectious foci (Øvstebø et al., 2004;Navarro et al., 2006;Peters et al., 2007).During recent years, many biomarkers have been evaluated and compared to find the best predictor of sepsis (Cho & Choi, 2014). Procalcitonin (PCT) has been identified as having a good diagnostic accuracy for predicting bacteraemia and pathogen DNAaemia in different clinical settings (Koivula et al., 2011;Mencacci et al., 2012), representing an advance over C-reactive protein (CRP) (Barati et al., 2008;Leli et al., 2014;Yu et al., 2010 Rabensteiner et al., 2014;Romualdo et al., 2014;Shozushima et al., 2011).To the best of our knowledge, no study described presepsin diagnostic accuracy in predicting both bacteraemia and bacterial DNAaemia, which was the first aim of this study.The second aim was to compare the diagnostic accuracy of presepsin with that of PCT and CRP. METHODSPatients and samples. This prospective observational stud...

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Usefulness of presepsin (sCD14 subtype) measurements as a new marker for the diagnosis and prediction of disease severity of sepsis in the Korean population

Cited by 83 publications

References 13 publications

Presepsin is an early monitoring biomarker for predicting clinical outcome in patients with sepsis

Presepsin is an early monitoring biomarker for predicting clinical outcome in patients with sepsis

Presepsin as an Early Reliable Diagnostic and Prognostic Marker of Neonatal Sepsis.

Diagnostic accuracy of presepsin (sCD14-ST) and procalcitonin for prediction of bacteraemia and bacterial DNAaemia in patients with suspected sepsis

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