Usefulness of plasma vitamin B6, B12, folate, homocysteine, and creatinine in predicting outcomes in heart transplant recipients

Nahlawi, Maher; Seshadri, Niranjan; Boparai, Navdeep; Naso, Arabi; Jacobsen, Donald W.; McCarthy, Patrick M.; Young, James B.; Robinson, Killian

doi:10.1016/s0002-9149(02)02194-x

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…Case -control Risk of acute MI was significantly lower for the highest tertile of vitamin B 6 intake compared with the lowest tertile of intake (OR 0·34, 95 % CI 0·19, 0·60) Yes Nahlawi et al (48) Follow-up 21 % of heart transplant recipients had PLP deficiency. Only 9 % of the patients with low PLP did not have CVD complications/death (P ¼0·05).…”

Section: Vitamin B 6 Supplementation Inflammation and Cvd Preventionmentioning

confidence: 99%

“…A number of studies have observed an inverse association between plasma concentrations of vitamin B 6 and risk of MI, independent of known CAD risk factors (44,46) , though not all studies confirmed this independent association (47) . In a study evaluating heart transplant recipients, it has been observed that about 21 % of the patients showed lower PLP concentrations and that only 9 % of those with lower plasma PLP levels did not have CVD complications (48) . Subjects in the highest quintile of PLP had a significantly reduced risk of MI but adjustment for either low-grade inflammation or smoking diminished this association (47) .…”

Section: Vitamin B 6 and Myocardial Infarctionmentioning

confidence: 99%

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Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Lotto

Friso

2011

Br J Nutr

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The objective of the present review is to highlight the relationship between low vitamin B 6 status and CVD through its link with inflammation. While overt vitamin B 6 deficiency is uncommon in clinical practice, increasing evidence suggests that marginal vitamin B 6 deficiency is rather frequent in a consistent proportion of the population and is related to an increased risk of inflammation-related diseases. Ample evidence substantiates the theory of atherosclerosis as an inflammatory disease, and low plasma vitamin B 6 concentrations have been related to increased CVD risk. Several studies have also shown that low vitamin B 6 status is associated with rheumatoid arthritis and chronic inflammatory bowel diseases, both of which hold an underlying chronic inflammatory condition. Furthermore, the inverse association observed between inflammation markers and vitamin B 6 supports the notion that inflammation may represent the common link between low vitamin B 6 status and CVD risk. In addition to the epidemiological evidence, there are a number of cell culture and animal studies that have suggested several possible mechanisms relating impaired vitamin B 6 status with chronic inflammation. A mild vitamin B 6 deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy.

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Section: Vitamin B 6 Supplementation Inflammation and Cvd Preventionmentioning

confidence: 99%

Section: Vitamin B 6 and Myocardial Infarctionmentioning

confidence: 99%

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Lotto

Friso

2011

Br J Nutr

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“…The prevalence of hyperhomocysteinemia in transplant patients has been associated with increased frequency of vascular complications. Conversely, it has been suggested that hyperhomocysteinemia might not have any causal role in the atherothrombotic complications of transplantation [7].…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia and deep vein thrombosis in orthotopic heart transplantation: A case report

Costea

Bhat

2004

American J Hematol

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Homocysteine has been recognized as a risk factor for atherosclerosis and arterial and venous thrombosis. Heart transplant patients have an increased prevalence of hyperhomocysteinemia. High homocysteine levels in transplant patients may promote development of cardiac allograft vasculopathy, but there is minimal information regarding the risk of venous thrombosis. The current case report illustrates the association of increased levels of homocysteine and hypercoagulable syndrome in a 36-year-old heart transplant patient with no previous history of clotting disorder. Both elevated homocysteine levels and extensive venous thrombosis responded promptly to treatment with a folate/B 12 /B 6 vitamin combination and enoxaparin. Am.

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“…Vitamin B6 deficiency was significant following intestinal transplantation and to lesser extent in kidney, liver and cardiac transplantation. [11,12]. Similarly, acute folic acid deficiency was observed after bone marrow transplantation [13].…”

Section: Vitamin K Livermentioning

confidence: 95%

“…Recently, Matarese et al reported a high incidence of vitamin B6 deficiency following small bowel and multivisceral transplantatioñ 96% [11]. Variable degrees of deficiencies have also been reported in liver transplantation (60%) [31], renal transplantation 50% [32], and cardiac transplantation 20% in [12]. Vitamin B6 deficiency occurred in about 59% of renal transplant recipients after more than 28 months [33].…”

Section: Water Soluble Vitaminsmentioning

confidence: 99%

Vitamins Status Following Solid Organ Transplantation

Shawaqfeh¹

2015

J Mol Biomark Diagn

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Solid organ transplantation is a popular solution for many end stage organ failures. The functional evaluation of these transplanted organs is multi-factorial and involves many aspects involving organ function, overall patient wellbeing and quality of life. Literature reports on vitamin status following transplantation had been collected together in this review article. This review summarizes the current status of research in this area with focus on reported deficiencies in vitamins following solid organ transplantation. The deficiencies in either fat-soluble vitamins like vitamin D, vitamin A and vitamin K as well as water soluble vitamins like vitamin B6, vitamin B12 and thiamine have been summarized. The reported deficiencies are noteworthy and necessitate a critical evaluation and interventions in many transplantation programs

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Usefulness of plasma vitamin B6, B12, folate, homocysteine, and creatinine in predicting outcomes in heart transplant recipients

Cited by 17 publications

References 25 publications

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Hyperhomocysteinemia and deep vein thrombosis in orthotopic heart transplantation: A case report

Vitamins Status Following Solid Organ Transplantation

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Usefulness of plasma vitamin B6, B12, folate, homocysteine, and creatinine in predicting outcomes in heart transplant recipients

Cited by 17 publications

References 25 publications

Vitamin B6: a challenging link between nutrition and inflammation in CVD

Vitamin B6: a challenging link between nutrition and inflammation in CVD

Hyperhomocysteinemia and deep vein thrombosis in orthotopic heart transplantation: A case report

Vitamins Status Following Solid Organ Transplantation

Contact Info

Product

Resources

About

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Vitamin B₆: a challenging link between nutrition and inflammation in CVD