Usefulness of oxidative stress marker evaluation at admission to the intensive care unit in patients with COVID-19

Abstract

Objective Two critical processes in the coronavirus disease 2019 (COVID-19) pandemic involve assessing patients’ intensive care needs and predicting disease progression during patients’ intensive care unit (ICU) stay. We aimed to evaluate oxidative stress marker status at ICU admission and ICU discharge status in patients with COVID-19. Methods We included patients in a tertiary referral center ICU during June–December 2020. Scores of Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), and clinical severity, radiologic scores, and healthy discharge status were noted. We collected peripheral blood samples at ICU admission to evaluate total antioxidants, total oxidants, catalase, and myeloperoxidase levels. Results Thirty-one (24 male, 7 female) patients were included. At ICU admission, patients’ mean APACHE II score at ICU admission was 17.61 ± 8.9; the mean SOFA score was 6.29 ± 3.16. There was no significant relationship between clinical severity and oxidative stress (OS) markers nor between radiological imaging and COVID-19 data classification and OS levels. Differences in OS levels between patients with healthy and exitus discharge status were not significant. Conclusions We found no significant relationship between oxidative stress marker status in patients with COVID-19 at ICU admission and patients’ ICU discharge status.

Dynamic Thiol Disulphide Homeostasis in the Follow-Up of the Prognosis of Patients Treated for COVID-19 in the Intensive Care Unit

“…Although ICU admission criteria in the COVID-19 pandemic may differ depending on the severity of the epidemic wave and available resources, the main criteria are generally similar. Certain laboratory values such as CRP, D-dimer, LDH, urea, creatine, albumin, and WBC are examples of these, as well as criteria such as low oxygen saturation, hemodynamic instability, presence of ARDS, coma scores, and the need for mechanical ventilation [15,16]. The findings of the patients included in our study were consistent with these criteria.…”

“…Thiol concentrations have been reported to be a good biomarker in determining admission to the intensive care unit in relation to the severity of the disease [20]. However, there is a study that reports the inverse of these findings [16]. Although native thiol levels varied depending on the treatments given to those who died from COVID-19 and those who were discharged from COVID-19 in our study, total thiol levels increased in lockstep with the length of stay in the intensive care unit.…”

Obesity‐dependent molecular alterations in fatal COVID‐19: A retrospective postmortem study of metabolomic profile of adipose tissue

“…These discrepancies could be attributed to variations in participant characteristics and the type of sample affecting oxidative damage. Patients with COVID‐19 have consistently shown decreased systemic antioxidant capacity 47,55,56 . Our OB group exhibited higher GPx activity, whereas NRF2 expression and SOD and myeloperoxidase (MPO) activities did not differ between groups, suggesting that obesity‐related antioxidant activity may be focused on H 2 O 2 degradation as a compensatory response to oxidative stress or other metabolic disorders prevalent in adipose tissue of obese individuals 57,58 .…”

Value of thiol and ischemia modified albumin (IMA) in predicting mortality in serious COVID-19 pneumonia

“…Acute inflammation, cytokine storm, acute thromboembolic events and impaired oxidant-antioxidant balance indicate a possible relationship between the pathophysiology of COVID-19 and OS [ 27 ]. There is a strong relationship between inflammation and OS; one is easily induced by the other [ 28 ].…”