Usefulness of oral dipyridamole therapy for angiographic slow coronary artery flow

Kurtoğlu, Nuri; Akçay, Ahmet; Dindar, İsmet

doi:10.1016/s0002-9149(00)01503-4

Cited by 93 publications

(82 citation statements)

References 13 publications

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“…14,15 Oral dipyridamole therapy has been shown to normalize the flow in patients with CSFP. 16 However, questions have been raised whether the normalization of the coronary flow could in fact be due to the effect of the medicine, or caused by the remission since CTFC improved but did not become normal in patients who had repeat angiography without any treatment, as observed by Beltrame. 9 354 Clin.…”

Section: Discussionmentioning

confidence: 99%

Coronary Slow Flow Phenomenon and Risk for Sudden Cardiac Death Due to Ventricular Arrhythmias: A Case Report and Review of Literature

Saya

Hennebry

Lozano

et al. 2007

Clinical Cardiology

119

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We report a case of coronary slow flow phenomenon (CSFP) in a patient who underwent coronary angiography due to anginal chest pain, and recurrent syncope with complete normalization of flow after intracoronary adenosine. The patient was noted to have multiple episodes of nonsustained ventricular tachycardia (VT) on holter monitor and increased QTc dispersion on surface electrocardiogram (ECG). He responded very well to oral dipyridamole therapy with complete resolution of his symptoms and no episodes of VT on the event recorder at 3 mo. We reviewed the diagnosis and clinical features of CSFP and its association with increased QTc dispersion, and the role of oral dipyridamole therapy in this condition.

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Section: Discussionmentioning

confidence: 99%

Coronary Slow Flow Phenomenon and Risk for Sudden Cardiac Death Due to Ventricular Arrhythmias: A Case Report and Review of Literature

Saya

Hennebry

Lozano

et al. 2007

Clinical Cardiology

119

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“…They proposed that histopathologic abnormalities in microvascular structures cause or at least facilitate the increase in microvascular resistance. Later, Kurtoglu, et al, 22) using a TFC method, showed that dipyridamole, which has a vasodilator effect on microvascular coronary arteries, normalized SCF. Goel, et al 23) showed that definitively positive exercise testing was more common in SCF than in the normal coronary flow group.…”

Section: Discussionmentioning

confidence: 99%

<b>Comparison of Exercise QRS Amplitude Changes in Patients with Slow Coronary Flow Versus Significant Coronary Stenosis</b>

et al. 2004

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SUMMARYExercise Q, R, and S wave amplitude changes, called the QRS score, have been reported to be a marker of exercise-induced myocardial ischemia. Therefore, in this study, using the exercise QRS score, we sought to determine if slow coronary flow (SCF) phenomenon is associated with the exercise-induced myocardial ischemia.This retrospective study included 23 patients evaluated for suspected coronary artery disease and found to have SCF (group I) and 19 subjects with angiographically-defined significant coronary artery stenosis (group II). All study subjects underwent treadmill exercise testing using the modified Bruce protocol. For each subject the amplitude of the Q, R, and S waves in leads aVF and V 5 was measured manually using calipers before and immediately after exercise. The QRS score was calculated by subtracting the Q, R, and S wave differences in leads aVF and V 5 .There was no difference between the two groups with respect to demographic properties. The peak heart rate achieved, baseline and peak systolic-diastolic blood pressure, exercise duration, and the metabolic equivalent values were similar in both groups. The maximum ST-segment depression ratio was significantly lower in patients with SCF than those of significant coronary stenosis (0.8 ± 0.4 vs 1.3 ± 0.5 P = 0.001, respectively). However, the exercise QRS score was found to be similar in both groups (3.3 ± 2.3 vs 2.1 ± 3.0 P = 0.2, respectively).The data suggest that SCF phenomenon may alone lead to myocardial ischemia even in the absence of obstructed major epicardial coronary arteries as detected by similar exercise QRS scores to those of significant coronary artery stenosis. (Jpn Heart J 2004; 45: 419-428)

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“…Since its original description by Tambe et al in 1972, only scarce attention has been paid to this phenomenon and, consequently, its clinical significance has remained unclear. Some authors suggested that abnormal increase of small vessel resistance was the cause of the slow dye progression in selective coronary angiography (20)(21)(22). It is believed to represent coronary microvascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Tpeak-end Interval Duration and Tpeak-end/QT Ratio, and Arrhythmias in Patients with Coronary Slow Flow

Şen¹,

Yılmaz²,

Özcan³

et al. 2016

Int Cardiovasc Res J

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A B S T R A C TBackground: Coronary Slow Flow (CSF) is described as delayed opacification of the distal vasculature and angiographically Normal Coronary Arteries (NCA). Numerous studies have suggested that the interval from the peak to the end of electrocardiographic T wave (Tp-e) may correspond to transmural dispersion of repolarization and that increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. Objectives: The present study aimed to evaluate ventricular repolarization in patients with CSFby using Tp-e interval and Tp--e/QT ratio. Patients and Methods: This study was conducted on electrocardiographic parameters of 100 patients with angiographically proven NCA with CSF in all three coronary arteries and 100 patients with NCA without CSF. The patients were followed up for arrhythmias and clinical events. Results: Tp-e tail interval (120 ± 5.5 msn, 101 ± 3.9 msn; P < 0.001), Tp-e tangent interval (99 ± 4.0 msn, 78 ± 3.0 msn, P < 0.001), Tp-e tail/QT ratio (0.31 ± 0.004, 0.26 ± 0.003, P < 0.001), and Tp-e tangent/QT ratio (0.25 ± 0.003, 0.19 ± 0.003, P < 0.001) were significantly higher in the CSF patients compared to the NCA group. Rhythm holter analyses also showed that ventricular extrasystoles were higher (157 ± 22.5, 87 ± 11.9, P = 0.002) in the CSF group compared to the NCA group. Conclusions: Tp-e interval and Tp-e/QT ratio were significantly higher in the patients with CSF compared to the NCA group.

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Usefulness of oral dipyridamole therapy for angiographic slow coronary artery flow

Cited by 93 publications

References 13 publications

Coronary Slow Flow Phenomenon and Risk for Sudden Cardiac Death Due to Ventricular Arrhythmias: A Case Report and Review of Literature

Coronary Slow Flow Phenomenon and Risk for Sudden Cardiac Death Due to Ventricular Arrhythmias: A Case Report and Review of Literature

<b>Comparison of Exercise QRS Amplitude Changes in Patients with Slow Coronary Flow Versus Significant Coronary Stenosis</b>

The Relationship between Tpeak-end Interval Duration and Tpeak-end/QT Ratio, and Arrhythmias in Patients with Coronary Slow Flow

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