Usefulness of objective evaluations by fluorescence visualization device for differentiating between superficial oral squamous cell carcinoma and oral lichen planus

Kozakai, Ayako; Ono, Keisuke; Nomura, Takeshi; Takano, Nobuo; Shibahara, Takahiko

doi:10.1016/j.ajoms.2019.09.010

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…MeanV was reported to contribute to the detection of oral cancer [ 15 , 16 , 48 ]. On the other hand, Kozakai also reported that it is difficult to distinguish oral cancer from OLP [ 49 ]. In this study, MeanV (60.9) and MediV (58.4) for oral cancers were lower than for OPMDs (MeanV 72.1, MediV 69.8) and Others (MeanV 68.7, MediV 68.0).…”

Section: Discussionmentioning

confidence: 99%

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Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

Morikawa

Shibahara

Nomura

et al. 2020

Cancers

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Background: Oral cancer screening is important for early detection and early treatment, which help improve survival rates. Biopsy is the gold standard for a definitive diagnosis but is invasive and painful, while fluorescence visualization is non-invasive, convenient, and real-time, and examinations can be repeated using optical instruments. The purpose of this study was to clarify the usefulness of fluorescence visualization in oral cancer screening. Methods: A total of 502 patients, who were examined using fluorescence visualization with optical instruments in our hospitals between 2014 and 2019, were enrolled in this study. The final diagnosis was performed by pathological examination. Fluorescence visualization was analyzed using subjective and objective evaluations. Results: Subjective evaluations for detecting oral cancer offered 96.8% sensitivity and 48.4% specificity. Regarding the objective evaluations, sensitivity and specificity were 43.7% and 84.6% for mean green value, 55.2% and 67.0% for median green value, 82.0% and 44.2% for coefficient of variation of value, 59.6% and 45.3% for skewness, and 85.1% and 75.8% for value ratio. For the sub-analysis of oral cancer, all factors on objective and subjective evaluation showed no significant difference. Conclusions: Fluorescence visualization with subjective and objective evaluation is useful for oral cancer screening.

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Section: Discussionmentioning

confidence: 99%

“…However, it is difficult to eliminate environmental factors completely in clinical practice. Therefore, in this study, we corrected it by using a normal mucosa as a control, represented by VRatio [ 7 , 15 , 16 , 17 , 49 ]. In this study, VRatio for oral cancers (68.9%) lower than that of OPMDs and Others (OPMDs 93.8%, Others 95.8%).…”

Section: Discussionmentioning

confidence: 99%

Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

Morikawa

Shibahara

Nomura

et al. 2020

Cancers

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“…A biopsy can provide evidence for a definitive diagnosis, but has the drawback of being surgically invasive. Recently, fluorescence visualization devices (FV) have been reported to be useful in the early identification and diagnosis of potentially malignant disorders of the oral cavity 9,18,23) . An FV is easy to operate, allowing images to be obtained at the chairside in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

“…An FV uses blue light (wavelength, 400-460 nm) to illuminate collagen cross-links (CCL) or flavin adenine dinucleotides (FAD) 9,13) . A selective filter allows the viewer to directly visualize the apple-green autofluorescence emitted by normal tissue, defined as fluorescence visualization retention (FVR) 12,13,22) .…”

Section: Introductionmentioning

confidence: 99%

“…Such dark-brown areas are referred to as fluorescence visualization loss (FVL). They arise as a result of absorption of a specific blue light due to the breakdown of CCL, decreases in FAD, and increases in hemoglobin 9,12,13,22) . In tissue with a thickened keratinized layer such as leukoplakia, fluorescence strongly increases due to an increase in keratin, and is observed as a white area.…”

Section: Introductionmentioning

confidence: 99%

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Early Detection of Leukoplakic Oral Squamous Cell Carcinoma Using 4NQO-induced Rat Tongue Cancer Model: Study Utilizing Fluorescence Intensity and Histopathological Evaluation

Masuda

Yamamoto

Shibahara

2022

Bull. Tokyo Dent. Coll.

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Early identification of leukoplakic oral squamous cell carcinoma (OSCC) is difficult. The purpose of this study was to determine whether it was possible to detect change from normal epithelium to leukoplakic OSCC using a fluorescence visualization (FV) device in a 4-nitroquinoline 1-oxide (4NQO) -induced rat tongue cancer model. If successful, this would facilitate early detection of OSCC. The rats (3 groups of 5) were administered 50 ppm 4NQO in their drinking water over a period of 10, 15, or 20 weeks. Five nontreated rats were used as a control group. Images of their tongues obtained by FV were analyzed for change in fluorescence intensity (FI) using image analysis software. Immunoreaction for anti-CK13, anti-CK17, and anti-E-cadherin antibodies was also histopathologically evaluated. Receiver operating characteristic (ROC) analysis was used to calculate the cut-off values, sensitivity, specificity, and area under the curve. The most marked change in FI was found between the control and 10-week groups, with an increase observed in its average value and range in the latter. These findings differed from those characteristic of leukoplakia. No significant difference was observed in the positive cell rate for immunoreaction for anti-CK13 or anti-CK17 antibodies between the control and 10-week groups. A significant decrease was observed in the positive pixel ratio of immunoreaction for anti-E-cadherin antibody in the 10-week group in comparison with in the control group (p <0.05). These results showed that disruption of intercellular adhesion could be observed at 10 weeks. In the ROC analysis, the FI cut-off value in the 10-week and control groups was 51.9, sensitivity 95.5%, and specificity 96.9%. This indicated that normal epithelium could be accurately distinguished from low-grade dysplasia with high probability. These results demonstrate that analysis of change in FI as measured by FV could facilitate early detection of leukoplakic OSCC.

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Potential application of a non-contact tool using measurable autofluorescence in oral leukoplakia

Kokuryo,

Yoshiga,

Haraguchi

et al. 2024

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Usefulness of objective evaluations by fluorescence visualization device for differentiating between superficial oral squamous cell carcinoma and oral lichen planus

Cited by 12 publications

References 17 publications

Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

Early Detection of Leukoplakic Oral Squamous Cell Carcinoma Using 4NQO-induced Rat Tongue Cancer Model: Study Utilizing Fluorescence Intensity and Histopathological Evaluation

Potential application of a non-contact tool using measurable autofluorescence in oral leukoplakia

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