2010
DOI: 10.1016/j.amjcard.2010.03.062
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Usefulness of Neutrophil to Lymphocyte Ratio in Predicting Short- and Long-Term Mortality After Non–ST-Elevation Myocardial Infarction

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Cited by 410 publications
(376 citation statements)
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“…In contrast to the phagocytic and killing effects of neutrophils, lymphocytes fulfill the regulatory function of the immune system (12,(16)(17)(18). Increased neutrophil count was found to be associated with infarct size and adverse angiographic outcomes in patients with myocardial infarction (12,19,20), while low lymphocyte count was related to adverse outcomes in patients with myocardial infarction and chronic heart failure (12,21,22). Since NLR reflects both immune pathways and is probably less affected by confounding conditions, it may be more predictive than either parameter alone (12).…”
Section: Discussionmentioning
confidence: 99%
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“…In contrast to the phagocytic and killing effects of neutrophils, lymphocytes fulfill the regulatory function of the immune system (12,(16)(17)(18). Increased neutrophil count was found to be associated with infarct size and adverse angiographic outcomes in patients with myocardial infarction (12,19,20), while low lymphocyte count was related to adverse outcomes in patients with myocardial infarction and chronic heart failure (12,21,22). Since NLR reflects both immune pathways and is probably less affected by confounding conditions, it may be more predictive than either parameter alone (12).…”
Section: Discussionmentioning
confidence: 99%
“…It was also reported to be associated with the severity of coronary artery lesions (13,15). In recent years, there has been a focus on white blood cell subtypes such as neutrophil, lymphocyte, and neutrophil to lymphocyte ratio as (12). Neutrophils are effective in ongoing active non-specific inflammation through the secretion of various inflammatory enzymes and mediators including elastase, myeloperoxidase, and freeoxygen radicals.…”
Section: Discussionmentioning
confidence: 99%
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“…NLR has been shown to predict short and longterm mortality in patients with both ST and non-ST elevation myocardial infarction and in patients undergoing percutaneous coronary interventions. 10,11,17,18 NLR has also been shown to be predict severity of coronary artery disease 19 and patency of bare metal stents after percutaneous coronary interventions and saphenous vein grafts after coronary artery bypass surgery. 20,21 Despite this, relatively few studies have investigated the NLR in patients with chronic kidney disease.…”
Section: Discussionmentioning
confidence: 99%
“…Studies investigating the association with mortality evaluated in-hospital, post-discharge, 30th day and 6th month mortality rates [28,29]. The study by Azab et al from Staten University (Staten Island, New York, USA) had the longest follow-up period [30]. This study evaluated NLR values at presentation and mean NLR values (average NLR value calculated from 3 different differential white blood cell count on different days) in 619 ACS patients with unstable angina pectoris/ non-ST segment elevation, and 4th year mortality rates from USA Social Security Mortality Index records [28,29].…”
Section: Discussionmentioning
confidence: 99%