Usefulness of N-Terminal-Pro-B-Type Natriuretic Peptide as a Screening Tool for Identifying Pediatric Patients With Congenital Heart Disease

Moses, Emmanuel Jairaj; Mokhtar, Sharifah Ainon Ismail; Hamzah, Amir; Abdullah, Basir Selvam; Yusoff, Narazah Mohd

doi:10.1309/lmw0u87cothxgelf

Cited by 8 publications

(10 citation statements)

References 22 publications

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“…The subjects with CHD had the highest level of mean NT-proBNP compared to the other causes of heart failure, which is similar to what other researchers have reported (29,31,32). This may be due to the fact that CHD being a structural abnormality of the heart may cause more profound release of the cardiac bio-marker when there is heart failure.…”

Section: Discussionsupporting

confidence: 88%

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Isah

Sadoh

Iduoriyekemwen

2017

Cardiovasc. Diagn. Ther.

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Section: Discussionsupporting

confidence: 88%

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Isah

Sadoh

Iduoriyekemwen

2017

Cardiovasc. Diagn. Ther.

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“…Moses et al found that NT-proBNP level in cyanotic subjects (mean 1,023 pg/mL) was higher than in acyanotic subjects (mean 372 pg/mL). 21 One subject of our three cyanotic subjects had lower NT-proBNP than the other two subjects, possibly due to drug therapy for heart failure. It has been well established that NT-proBNP level decreases in most patients who receive drug therapy Median NT-proBNP level in subjects with severe heart failure according to type of heart disease for heart failure.…”

Section: Discussionmentioning

confidence: 77%

Correlation of heart failure severity and N-terminal pro-brain natriuretic peptide level in children

Mahrani

Nova

Saleh

et al. 2017

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“…Their AUC value was 0.79, with a cut-off point of 98 pg/mL, with sensitivity 82% and specificity 46%. 3 The study was similar to ours, in terms of subject age and study design. However, Moses et al included pediatric patients admitted to the Cardiology Division at Penang Hospital, Malaysia, who had suspected congenital heart defects based on prior examination at the hospital.…”

Section: Discussionmentioning

confidence: 57%

“…However, Moses et al included pediatric patients admitted to the Cardiology Division at Penang Hospital, Malaysia, who had suspected congenital heart defects based on prior examination at the hospital. 3 We included children who presented with shortness of breath.…”

Section: Discussionmentioning

confidence: 99%

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Using N-terminal pro-B-type natriuretic peptide to diagnose cardiac abnormalities in children with dyspneaen with dyspnea

Mukalla

Nova

Legiran

et al. 2017

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Background. Dyspnea could be caused by various reason, one of which is the presence of cardiac abnormality. Physical examination sometimes difficult to distinguish breath caused by heart abnormalities, especially small children, so we need another way to find out.Objective. To evaluate whether the examination of NT-proBNP levels can be used as a screening tool to diagnose cardiac abnormality in children presenting with dyspnea.Methods. A Cross sectional study was conducted from August to October 2015 on pediatric patients aged 1 month to 18 years presenting with dyspnea in pediatric ward Mohammad Hoesin Hospital Palembang. All subjects performed blood sampling for NT-proBNP examination and echocardiography to assess the presence of cardiac abnormalities. The diagnostic value analyzed by ROC curve, and determined the optimal cut-off point, sensitivity and specificity. Result. We obtained 58 subjects with median age 9.5 (1-180) months, consisted of 39 subjects with cardiac abnormalities and 19 subjects without cardiac abnormality. There is a significant difference (p = 0.002) of NT-proBNP levels in both groups with a median 1,775 (189-9,000) pg/ml vs 759 (245-9,000) pg/ml. In ROC curve analysis, AUC value was 0.75, and at the optimal cut-off point 1,235 pg/ml, sensitivity was 74.4% and specificity was 73.7%.Conclusion. The level of NT-proBNP can be used to diagnose cardiac abnormalities in children presenting with dyspnea.

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Usefulness of N-Terminal-Pro-B-Type Natriuretic Peptide as a Screening Tool for Identifying Pediatric Patients With Congenital Heart Disease

Cited by 8 publications

References 22 publications

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Correlation of heart failure severity and N-terminal pro-brain natriuretic peptide level in children

Using N-terminal pro-B-type natriuretic peptide to diagnose cardiac abnormalities in children with dyspneaen with dyspnea

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