Usefulness of Mean Corpuscular Volume for Detection of Advanced Colorectal Cancer in Patients Older than 85 Years

Kato, Motohiko; Kubosawa, Yoko; Hiarai, Yuichiro; Abe, Keiichiro; Hirata, Tetsu; Takada, Yoshiaki; Wada, Mitsuru; Takatori, Yusaku; Kinoshita, Satoshi; Takabayashi, Kaoru; Kikuchi, Masahiro; Ohishi, Takashi; Uraoka, Toshio

doi:10.1159/000485378

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…MCHC is calculated according to MCH and MCV results (MCHC=MCH/MCV), and showed the optimal sensitivity and specificity with CRC prognostic risk, so we selected MCHC to be included in our ARR formula. Kato et al reported that [52] , MCV was an independent predictor irrespective of the location of the tumor, whereas anemia symptom was not an independent predictor. Other studies suggest otherwise [46] , lower MCV was associated with advanced T stage and proximal tumor location, while HGB in patients with tumors in proximal colon was significantly lower relative to distal colon and rectum.…”

Section: Discussionmentioning

confidence: 97%

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Li¹,

Wu²,

Xing³

et al. 2020

J. Cancer

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Background: Many indicators of peripheral blood in routine blood test (BRT) results of colorectal cancer (CRC) patients are related to prognosis. Currently, indexes such as NLR (Neutrophil-to-Lymphocyte Ratio), PLR (Platelet-to-Lymphocyte Ratio) and LMR (Lymphocyte-to-Monocyte ratio) evaluate the survival risk of patients by assessing the inflammatory-immune status of CRCs. These indexes are more comprehensive and accurate than independent estimates. We hope to design more effective indexes through fully considering the correlation and significance between BRT indicators and prognosis, so as to play a guiding role in clinical malignant estimation of CRCs. Methods: 701 CRCs in training set and 256 CRCs in test set were included in the study samples, and their clinical data, tumor pathology results and peripheral blood routine results were collected. The prognosis, progression, and survival status of all patients were determined after follow-up. Above data were used for statistical analysis and designing new indexes. Results: It was found that high NE, MONO, RDW-CV/SD and PLT in peripheral blood indicated poor prognosis of DFS and OS. Conversely, CRCs with postoperative tumor progression or death had lower LY, EO, RBC, HGB, HCT, MCV, MCH, MCHC, PDW, and P-LCR. IRR, ARR and CRR related to infection, anemia and coagulation were designed respectively using the largest AUC indicators (P<0.05) selected by ROC curve. The formula: IRR= (NE*MONO)/(LY*EO); ARR= (HGB*MCHC)/RDW-CV; CRR=PLT/PDW. Results of Kaplan-Meier survival analysis and multivariate COX proportional hazard analysis adjusted for age, gender, TNM stage, infiltration, adhesion showed IRR, ARR, CRR were all able to be used as the evaluation standard of survival of CRC. The result was also authenticated in the test set. Conclusion: We designed three different prognostic indexes of colorectal cancer, IRR, ARR and CRR, which could be used as risk indicators of CRC prognosis, tumor progression and survival.

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Section: Discussionmentioning

confidence: 97%

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Li¹,

Wu²,

Xing³

et al. 2020

J. Cancer

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“…Previously, there were several studies focusing on the clinical role of MCV in CRC, showing MCV was associated with the risk of colorectal adenoma ( 10 ), advanced CRC ( 11 ) and response to chemotherapy in CRC ( 12 , 13 ) with even conflicting results and only one study was available investigating the prognostic role of pretreatment MCV in CRC patients ( 16 ). In this study, Hidemasa and his colleagues carried out a retrospective analysis in 1174 patients with stage I, II, and III CRC, and it was found that MCV of <80 fL was a favorable prognostic factor in CRC.…”

Section: Discussionmentioning

confidence: 99%

“…As a measure of the average volume of a red blood cell, mean corpuscular volume (MCV) was related to the prognosis of liver cancer ( 7 ), esophageal cancer ( 8 ) and adenocarcinomas of the gastroesophageal junction ( 9 ). Interestingly enough, MCV was also reported to be associated with the risk of colorectal adenoma ( 10 ), advanced CRC ( 11 ) and response to chemotherapy in CRC ( 12 , 13 ), suggesting MCV had the potential to be an ideal biomarker and be put into clinical application. In particular, previous study revealed that high MCV value may be used as an index of the risk of colorectal adenomas ( 10 ), but a recent research reported decreased MCV was an independent predictor for the detection of advanced colorectal cancer ( 11 ), indicating that the clinical role of MCV in colorectal cancer was still uncertain.…”

Section: Introductionmentioning

confidence: 99%

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Liu

Yang

et al. 2021

Front. Oncol.

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ObjectiveTo elucidate the prognostic significance of mean corpuscular volume (MCV), with implications of habitual alcohol intake in stage II-III colorectal cancer (CRC).BackgroundMCV had the potential to become an ideal prognostic biomarker and be put into clinical application. Few studies, however, have explored whether habitual alcohol intake which greatly increased the value of MCV would affect the prognostic role of MCV.MethodsEligible patients were identified from the CRC database of Fudan University Shanghai Cancer Center (FUSCC) between January 2012 and December 2013. Survival analyses were constructed using the Kaplan–Meier method to evaluate the survival time distribution, and the log-rank test was used to determine the survival differences. Univariate and multivariate Cox proportional hazard models were built to calculate the hazard ratios of different prognostic factors.ResultsA total of 694 patients diagnosed with stage II-III CRC between January 2012 and December 2013 were identified from FUSCC. Low pretreatment MCV was independently associated with 72.0% increased risk of overall mortality compared with normal MCV (HR = 1.720, 95%CI =1.028-2.876, P =0.039, using normal MCV as the reference). In patients with habitual alcohol intake, however, pretreatment MCV positively correlated with the mortality (P = 0.02) and tumor recurrence (P = 0.002) after adjusting for other known prognostic factors.ConclusionsIn CRC patients without habitual alcohol intake, low (<80 fL) level of pretreatment MCV was a predictor of poor prognosis. In patients with habitual alcohol intake, however, pretreatment MCV showed the opposite prognostic role, which would elicit many fundamental studies to elucidate the mechanisms behind.

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“…Kato M [25] suggested that the decrease of MCV could be used as an independent predictor of late CRC and further colonoscopy was necessary for people over 85 years with the decrease of MCV. In our study, the MCV of NAFLD-CRC (88.59 ± 9.27 fl) and nonNAFLD-CRC (88.29 ± 8.37 fl) is significantly lower than that of NAFLD-NonCRC (90.89 ± 6.78 fl, P < 0.001).…”

Section: Correlation Between Gender Age and Crc In Nafld Populationmentioning

confidence: 99%

Value of routine test for identifying colorectal cancer from patients with nonalcoholic fatty liver disease

Yang

Chen

2020

BMC Gastroenterol

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Background Nonalcoholic fatty liver disease (NAFLD) is a risk factor for colorectal neoplasms. Our goal is to explore the relationship between NAFLD and colorectal cancer (CRC) and to analyze potential indicators for screening CRC in NAFLD based on clinical big data. Methods Demographic information and routine clinical indicators were extracted from Xiangya Medical Big Data Platform. 35,610 NAFLD cases without CRC (as group NAFLD-CRC), 306 NAFLD cases with CRC (as group NAFLD-NonCRC) and 10,477 CRC cases without NAFLD were selected and evaluated. The CRC incidence was compared between NAFLD population and general population by Chi-square test. Independent sample t-test was used to find differences of age, gender and routine clinical indicators in pairwise comparisons of NAFLD-CRC, NAFLD-NonCRC and nonNAFLD-CRC. Results NAFLD population had a higher CRC incidence than general population (7.779‰ vs 3.763‰, P < 0.001). Average age of NAFLD-CRC (58.79 ± 12.353) or nonNAFLD-CRC (59.26 ± 13.156) was significantly higher than NAFLD-nonCRC (54.15 ± 14.167, p < 0.001). But age had no significant difference between NAFLD-CRC and nonNAFLD-CRC (P > 0.05). There was no different gender distribution for three groups (P > 0.05). NAFLD-CRC had lower anaemia-related routine clinical indicators such as decrease of red blood cell count, mean hemoglobin content and hemoglobin than NAFLD-nonCRC (P < 0.05 for all). Anemia of NAFLD-CRC was typical but it might be slighter than nonNAFLD-CRC. More interestingly, NAFLD-CRC had distinct characteristics of leukocyte system such as lower white blood cell count (WBC) and neutrophil count (NEU_C) and higher basophil percentage (BAS_Per) than nonNAFLD-CRC and NAFLD-nonCRC (P < 0.05 for all). Compared with NAFLD-nonCRC, the change of WBC, BAS_Per and NEU_C in NAFLD-CRC was different from that in nonNAFLD-CRC. In addition, NAFLD-CRC had a higher level of low density lipoprotein (LDL) and high density lipoprotein (HDL), lower level of triglyceride (TG) and Albumin-to-globulin ratio (A/G) than NFLD-nonCRC (P < 0.05 for all). Conclusions NAFLD is associated with a high incidence of CRC. Age is an important factor for CRC and the CRC incidence increases with age. Anemia-related blood routine clinical indicators, leukocyte system and blood lipid indicators may be more important variables for identifying CRC in NAFLD. So blood routine test and liver function/blood lipid test are valuable for screening CRC in NAFLD.

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Usefulness of Mean Corpuscular Volume for Detection of Advanced Colorectal Cancer in Patients Older than 85 Years

Cited by 4 publications

References 12 publications

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Value of routine test for identifying colorectal cancer from patients with nonalcoholic fatty liver disease

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