Usefulness of Magnetic Resonance Imaging in the Diagnosis of Juxtaglomerular Cell Tumors: A Report of 10 Cases and Review of the Literature

Faucon, Anne‐Laure; Bourillon, Camille; Grataloup, C.; Baron, Stéphanie; Bernadet-Monrozies, P.; Vidal‐Petiot, Emmanuelle; Azizi, Michel; Amar, Laurence

doi:10.1053/j.ajkd.2018.09.005

Cited by 22 publications

(32 citation statements)

References 16 publications

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“…The wider recognition of JGCT is another crucial reason for the small size of JGCT. The mean diameter of JGCTs reported in global studies in 1983, 1993, and 2019 decreased from 4.1 cm to 2.9 cm, and then to 1.8 cm (5,8,11). Over the past seven years, all six JGCTs diagnosed in our institution were less than 1.5 cm; before this study, the mean diameter of JGCTs was reported to be 2.5 cm.…”

Section: Small Size Of Jgct and The Pathological Foundationmentioning

confidence: 51%

“…Current literatures have mostly focused on the diagnosis of JGCTs. Surgical management, the only possible way to cure this tumor, has yet to be fully addressed, mostly due to a lack of cases and limited surgical experience (3)(4)(5). Previous literature review in 2008 summarized most JGCT cases at that time and showed that open nephrectomy and partial nephrectomy could manage JGCTs excellently, while only one laparoscopic partial nephrectomy (LPN) was mentioned then (6).…”

Section: Introductionmentioning

confidence: 99%

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The Small Size and Superficial Location Suggest That Laparoscopic Partial Nephrectomy Is the First Choice for the Treatment of Juxtaglomerular Cell Tumors

Huang

Tong

et al. 2021

Front. Endocrinol.

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BackgroundJuxtaglomerular cell tumor (JGCT) is a very rare disease, and surgical resection is the only possible way to cure this tumor. Open nephrectomy and partial nephrectomy have been reported to manage JGCTs with excellent results in the previous reviews. Laparoscopic surgery has been popularized in recent years, while critical issues associated with laparoscopic surgical management have been seldom reported. We summarized the JGCTs in our center to discover the optimal surgical management and its anatomic foundation.MethodsIn this retrospective study, we enrolled a total of 14 JGCT patients. All patients received surgeries and were followed up for up to 11 years. We mainly summarized the size and location of tumors, imaging features, and surgical strategies. A descriptive statistical analysis was performed.ResultsThe JGCTs in this study had a median size of 1.35 cm and all located superficially, mainly in the cortical or subcortical area of the kidney. All 14 patients had hypertension, ten had hypokalemia, and seven had elevated plasma renin activity. Pathologically, JGCT cells were polygonal or spindle shape, with positive CD34 and vimentin immunostaining. All patients received partial nephrectomy; nine were laparoscopic, and five were open. Laparoscopic partial nephrectomy (LPN) was performed in seven out of eight patients over the last nine years. Postoperative blood pressure, serum potassium, and plasma renin activity were normal in all patients. No recurrence occurred within a median follow-up of 60 months.ConclusionThe small size and superficial location are the characteristic anatomic features of JGCT; they suggest that LPN is the preferred surgical strategy. Laparoscopic ultrasound is helpful for the intraoperative detection of small JGCTs. Longer follow-up is required to examine the biological behavior of JGCTs and the effect of LPN.

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Section: Small Size Of Jgct and The Pathological Foundationmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

The Small Size and Superficial Location Suggest That Laparoscopic Partial Nephrectomy Is the First Choice for the Treatment of Juxtaglomerular Cell Tumors

Huang

Tong

et al. 2021

Front. Endocrinol.

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“…A ressonância magnética nuclear tem particular interesse, já que apresentará maior acuidade diagnóstica na distinção entre estes dois tumores. 7,8 O CCR cursa frequentemente com HTA, pelo que o cateterismo das veias renais poderá ser necessário para confirmar o diagnóstico. No entanto, este é um procedimento invasivo, com elevada taxa de falsos negativos, justificado pela natureza cortical e drenagem venosa pericapsular da maioria dos reninomas descritos.…”

Section: Discussionunclassified

Reninoma: Uma Causa Rara de Hipertensão Endócrina

et al. 2020

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Juxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 – 28 ng/dL), renin > 1000 mIU/mL (4.4 – 46.2 mIU/mL)]. Abdominal computed tomography scan identified a heterogeneous nodule located in the middle third of the right kidney, with 3.7 cm. Partial nephrectomy was performed and histological analysis confirmed the diagnosis of reninoma. After surgery, the patient had normal levels of aldosterone (9.2 ng/dL) and renin (1.20 mIU/mL), as well as normal blood pressure. The authors want to highlight this potentially curable cause of endocrine hypertension. Surgical resection is the treatment of choice and leads to normalization of blood pressure.

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“…Juxtaglomerular cell tumor (JGCT) is a rare renin-secreting neoplasm derived from modified smooth muscle cells of the juxtaglomerular apparatus within the walls of the glomerular arterioles [15]. It is now widely recognized as a rare cause of hypertension and secondary hyperaldosteronism, with approximately 170 cases reported in the literature to date [100]. JGCT typically occurs in young adults; it is twice as common in women and has a peak incidence in the second to third decade of life [15,101].…”

Section: Juxtaglomerular Cell Tumormentioning

confidence: 99%

“…CT studies typically show a well-circumscribed, isoattenuating to hypoattenuating cortical-based tumor without significant enhancement on contrast administration; the findings may raise suspicion for RCC or angiomyolipoma, or in the case of isodense non-enhancing tumors, may go completely undetected on CT imaging [100,[103][104][105]. MRI of JGCTs usually demonstrates isointensity on T1-weighted images and variable hyperintensity on T2-weighted images with mild heterogeneous contrast enhancement [100,103]. Overall the imaging features of JGCTs are largely non-specific and cannot be distinguished from other solid renal neoplasms [104].…”

Section: Juxtaglomerular Cell Tumormentioning

confidence: 99%

Vascular Neoplasms and Related Lesions of Kidney

Lin¹,

Ro²

2020

ann urol oncol

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Vascular tumors arising in the kidney are distinctly uncommon occurrences and have not been well-characterized in the literature; most cases have been documented in single reports or small case series. These tumors often exhibit nonspecific clinical and radiologic features and may mimic malignant epithelial tumors such as renal cell carcinoma (RCC) on imaging studies, necessitating nephrectomy with pathologic examination for definitive diagnosis. In addition, since primary renal vascular tumors are rare and infrequently encountered in surgical pathology specimens, they are often not considered in the differential diagnosis and therefore may be systematically under-diagnosed. In this review, we discuss the clinical and morphologic features of benign, borderline, and malignant vascular neoplasms and related lesions arising in the kidney, with a focus on recent, clinically relevant advances in imaging, histopathologic diagnosis, and treatment.

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Usefulness of Magnetic Resonance Imaging in the Diagnosis of Juxtaglomerular Cell Tumors: A Report of 10 Cases and Review of the Literature

Cited by 22 publications

References 16 publications

The Small Size and Superficial Location Suggest That Laparoscopic Partial Nephrectomy Is the First Choice for the Treatment of Juxtaglomerular Cell Tumors

The Small Size and Superficial Location Suggest That Laparoscopic Partial Nephrectomy Is the First Choice for the Treatment of Juxtaglomerular Cell Tumors

Reninoma: Uma Causa Rara de Hipertensão Endócrina

Vascular Neoplasms and Related Lesions of Kidney

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