Usefulness of magnetic particle imaging for monitoring the therapeutic effect of magnetic hyperthermia

Murase, Kenya; Aoki, Marina; Banura, Natsuo; Nishimoto, Kohei; Mimura, Atsushi; Hamakawa, Kazuhiro; Kuboyabu, Tomomi; Yabata, Isamu

doi:10.1109/iwmpi.2015.7107035

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…[20,817] MPI has been shown promising for cancer imaging, stem cell tracking, and angiography, [818] and even monitoring the therapeutic effect of magnetic hyperthermia. [819] Compared to other imaging techniques such as CT, MRI and PET, MPI combines high temporal resolution, sub-millimeter spatial resolution images and high sensitivity [820] with the ability of fast volumetric imaging. [821] Surprisingly, far better resolution of 250 µm and sensitivity of 20 × 10 −9 m appear feasible in theory.…”

Section: Mpimentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

192

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Mpimentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

192

171

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“…Both the real and the imaginary components of ac magnetic susceptibility (χ = χ′ − iχ″) can be used for image reconstruction, making csMPI of great potential in biomedical applications like most of the MPI mode. For instance, the volumetric power dissipation of MFH is linearly associated with the magnitude of the imaginary component of χ [36] and thus csMPI could be used to map the heating efficiency distribution of MFH [1,3,4,37]. Moreover, the Brownian relaxation is highly influenced by the microenvironment around MNPs [38][39][40][41], which might allow the csMPI to distinctively map the distribution of the bound and free MNPs.…”

Section: Measurement Science and Technologymentioning

confidence: 99%

Influence of signal bandwidth and phase delay on complex susceptibility based magnetic particle imaging

Jiang

Shi

et al. 2019

Meas. Sci. Technol.

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In this paper, the influences of signal bandwidth and phase delay on the spatial resolution of complex susceptibility based magnetic particle imaging (csMPI) are investigated by modeling the transfer function of the measurement circuit. Based on the simulation and experimental results, it is found that the signal bandwidth and the phase delay will significantly impact on the spatial resolution of csMPI. To avoid the influence of narrow signal bandwidth and phase delay of measurement circuit on csMPI, a resonance measurement circuit with −3 dB bandwidth of 2.3 kHz (much larger than the signal bandwidth of the desired csMPI signal) and resonance frequency of 12.8 kHz is adopted to measure the weak nonlinear magnetization of the magnetic nanoparticles; a phase compensation is used when calculating the real and the imaginary components of ac magnetic susceptibility.

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Usefulness of magnetic particle imaging for monitoring the therapeutic effect of magnetic hyperthermia

Cited by 2 publications

References 44 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Influence of signal bandwidth and phase delay on complex susceptibility based magnetic particle imaging

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