Usefulness of Macular Thickness Derived from Spectral-Domain Optical Coherence Tomography in the Detection of Glaucoma Progression

Lee, Kyoung Sub; Lee, Jong Rak; Na, Jung Hwa; Kook, Michael S.

doi:10.1167/iovs.12-11160

Cited by 20 publications

(23 citation statements)

References 51 publications

(58 reference statements)

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“…The results of our investigation suggest that the various TR thickness parameters of the RS-3000 OCT are in fact highly reproducible, and therefore may potentially be investigated for glaucoma diagnostic accuracy and accuracy in detection of glaucomatous progression. At the same time our results and the previously published results obtained with another OCT system [ 11 ] suggest that the benefits found in the current study for the TR thickness parameters may represent a general feature, and therefore their evaluation in various OCT systems is proposed.…”

Section: Discussionsupporting

confidence: 72%

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

et al. 2015

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PurposeTo evaluate the intrasession reproducibility of various thickness parameters used to diagnose and follow-up glaucoma, in particular circumpapillary total retinal thickness (cpTR) provided by the RS-3000 optical coherence tomograph (OCT).MethodsFifty-three healthy eyes of 28 subjects underwent three consecutive imaging with the RS-3000 Advance OCT (NIDEK, Aichi,Japan) to evaluate the intrasession reproducibility of circumpapillary total retinal thickness (cpTR), circumpapillary retinal nerve fiber layer thickness (cpRNFL), macular ganglion cell complex thickness (mGCC) and macular total retina thickness (mTR) measurements. Intraclass correlation (ICC), coefficient of variation (CV) and reproducibility coefficient (RC) were calculated for each parameter.ResultsThe ICC and CV values for mean cpTR and cpRNFL were 0.987 and 0.897, and 0.60% and 2.81%, respectively. The RC values for the mean cpTR and cpRNFL were 5.95 μm and 9.04 μm, respectively. For all cpTR parameters the ICC values were higher and both the CV and RC values were lower than those for the corresponding cpRNFL parameters. The ICC and CV values for superior mGCC, inferior mGCC, superior mTR and inferior mTR were 0.983, 0.980, 0.983 and 0.988, and 0.84%, 0.98%, 0.48% and 0.43%, respectively. The RC values for superior mGCC, inferior mGCC, superior mTR and inferior mTR were 2.86 μm, 3.12 μm, 4.41μm and 4.43 μm, respectively.ConclusionsIntrasession reproducibility of cpTR, mGCC and mTR measurements made on healthy eyes was high. Repeatability of cpTR measurements was better than that of the corresponding cpRNFL measurements. These results suggest that future clinical investigations addressing detection of glaucoma and glaucomatous progression with the RS-3000 OCT may benefit from focusing on the cpTR parameters.

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Section: Discussionsupporting

confidence: 72%

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

et al. 2015

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“…Overall, these results confirm the potential diagnostic ability of macular layer thickness that has already been established by numerous studies. 3,7,11,16,[19][20][21][22] These findings also demonstrate the potential of using fellow eyes as internal controls for diagnosing and longitudinally tracking glaucoma progression, avoiding the problem of interanatomic differences and variability. According to Asrani and colleagues, 8,23 macular thickness measurements of the fellow eye can be used as an effective control especially in the absence of a normative macular thickness database, as structural asymmetry has been long established as a typical feature in glaucoma progression.…”

Section: Discussionmentioning

confidence: 64%

“…25 Macular thinning could also be used as an alternative means of longitudinally tracking glaucoma progression together with pRNFL thickness analysis. 19 Our study has several limitations. Manual segmentation of macular layers, despite adding accuracy to the retinal thickness layer measurements, proves to be a somewhat subjective measure, prone to errors of interpretation.…”

Section: Discussionmentioning

confidence: 91%

Segmental Analysis of Macular Layers in Patients With Unilateral Primary Open-Angle Glaucoma

Zangalli

Ahmed²,

Waisbourd³

et al. 2016

Journal of Glaucoma

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“…Some recent investigations have demonstrated the utility and added value of macular SD-OCT imaging for detecting glaucoma, but its role remains less well defined with respect to progression. 3 – 10 …”

mentioning

confidence: 99%

Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range

Miraftabi

Amini

Morales

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeWe tested the hypothesis that the macular ganglion cell layer (GCL) thickness demonstrates a stronger structure-function (SF) relationship and extends the useful range of macular measurements compared with combined macular inner layer or full thickness.MethodsNinety-eight glaucomatous eyes and eight normal eyes with macular spectral domain optical coherence tomography (SD-OCT) volume scans and 10-2 visual fields were enrolled. Inner plexiform layer (IPL), GCL, macular retinal nerve fiber layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), and full thickness (FT) measurements were calculated for 8 × 8 arrays of 3° superpixels. Main outcome measures were local structure-function relationships between macular superpixels and corresponding sensitivities on 10-2 fields after adjusting for ganglion cell displacement, dynamic range of measurements, and the change point (total deviation value where macular parameters reached measurement floor).ResultsMedian (interquartile range [IQR]) mean deviation was −7.2 (−11.6 to −3.2) dB in glaucoma eyes. Strength of SF relationships was highest for GCIPL, GCL, GCC, and IPL (ρ = 0.635, 0.627, 0.621, and 0.577, respectively; P ≤ 0.046 for comparisons against GCIPL). Highest SF correlations coincided with the peak of GCL thickness, where the dynamic range was widest for FT (81.1 μm), followed by GCC (65.7 μm), GCIPL (54.9 μm), GCL (35.2 μm), mRNFL (27.5 μm), and IPL (20.9 μm). Change points were similar for all macular parameters (−7.8 to −8.9 dB).ConclusionsGCIPL, GCL, and GCC demonstrated comparable SF relationships while FT, GCC, and GCIPL had the widest dynamic range. Measurement of GCL did not extend the range of useful structural measurements. Measuring GCL does not provide any advantage for detection of progression with current SD-OCT technology.

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Usefulness of Macular Thickness Derived from Spectral-Domain Optical Coherence Tomography in the Detection of Glaucoma Progression

Cited by 20 publications

References 51 publications

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

Segmental Analysis of Macular Layers in Patients With Unilateral Primary Open-Angle Glaucoma

Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range

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