Usefulness of Liver Stiffness on Ultrasound Shear-Wave Elastography for the Evaluation of Central Venous Pressure in Children With Heart Diseases

Terashi, Eiko; Kodama, Yoshihiko; Kuraoka, Akio; Ishikawa, Yuichi; Nakamura, Makoto; Sagawa, Koichi; Ishikawa, Shiro

doi:10.1253/circj.cj-18-1313

Cited by 14 publications

(2 citation statements)

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“…There is also an independent relationship between liver stiffness and central venous pressure in patients with congenital heart disease. [7][8][9][10][11] The exact mechanism of development of liver fibrosis in patients with cardiac pathology is unknown. In cases with cardiac cirrhosis or Fontan palliation, liver fibrosis may occur independently of inflammation and may be triggered by repetitive mechanical stretching and compression of liver sinusoids and other adjacent cells, potentially as a result of passive liver congestion.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between echocardiographic parameters and albumin bilirubin (ALBI) score in patients with isolated secundum type atrial septal defect

et al. 2023

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Background It has been shown that the increase in volume and pressure in the right heart chambers increases liver stiffness. The Albumin‐Bilirubin (ALBI) score is a useful and easy‐to‐use score for objectively assessing liver function. There is no information in the literature about changes in ALBI score in patients with atrial septal defect (ASD). The aim of our study is to investigate the changes in ALBI score and its clinical impact in patients with ASD. Methods Of the 206 analyzed patients, 77 were excluded. The remaining 129 patients with secundum type ASD with left to right shunt were divided into three groups; Group I (16 patients with Qp/Qs < 1.5 and defect diameter < 10 mm), Group II (52 patients with Qp/Qs > 1.5 and defect diameter 10–20 mm) and Group III (61 patients with Qp/Qs > 1.5 and defect diameter > 20 mm). The ALBI score was calculated based on serum albumin and total bilirubin levels using the following formula: ALBI = (log10 bilirubin [umol/L] * .66) + (albumin [g/L] * ‐.085). Results ALBI scores as well as total bilirubin levels, transaminases, and functional‐structural heart abnormalities (increase in RA and RV dimensions, sPAP, ASD size and decrease in LVEF and TAPSE) showed a significant increasing trend from Group I to Group III (p < .001 for all comparisons). The mean ALBI scores for Group I, Group II, and Group III were ‐3.71 ± .37, ‐3.51 ± .25, and ‐3.27 ± .34, respectively. In multivariate linear regression analysis, ASD size, sPAP, RV‐RA diameter were found to be significantly associated with increased ALBI score. Conclusion The ALBI score offers a simple, evidence‐based, objective, and discriminatory method of assessing liver function in patients with ASD. ASD size, sPAP, RV and RA diameters were significantly associated with ALBI score.

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Section: Introductionmentioning

confidence: 99%

“…The liver, which has a fibrous capsule that is not capable of expanding sufficiently, increases liver stiffness due to congestion. There is also an independent relationship between liver stiffness and central venous pressure in patients with congenital heart disease 7–11 …”

Section: Introductionmentioning

confidence: 99%