2016
DOI: 10.1002/lt.24376
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Usefulness of liver stiffness measurement during acute cellular rejection in liver transplantation

Abstract: Liver stiffness measurement (LSM) is a useful method to estimate liver fibrosis and portal hypertension. The inflammatory process that takes place in post-liver transplant acute cellular rejection (ACR) may also increase liver stiffness. We aimed to explore the association between liver stiffness and the severity of ACR, as well as to assess the relationship between liver stiffness and response to rejection treatment in a prospective study that included 27 liver recipients with biopsy-proven ACR, 30 stable rec… Show more

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Cited by 36 publications
(21 citation statements)
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“…The inflammatory cascade driving acute cellular rejection (ACR), as with any inflammatory process, might be expected to increase LS . Crespo et al evaluated the association between LS and severity of biopsy‐proven ACR in liver transplanted patients. In their prospective study, TE achieved highest diagnostic accuracy, with an AUROC of 0.924 to discriminate mild from moderate/severe rejection.…”
Section: Methodsmentioning
confidence: 99%
“…The inflammatory cascade driving acute cellular rejection (ACR), as with any inflammatory process, might be expected to increase LS . Crespo et al evaluated the association between LS and severity of biopsy‐proven ACR in liver transplanted patients. In their prospective study, TE achieved highest diagnostic accuracy, with an AUROC of 0.924 to discriminate mild from moderate/severe rejection.…”
Section: Methodsmentioning
confidence: 99%
“…as part of MV. At LSM, median ALT was 25 [IQR [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]] IU/L. Twenty-one percent had METAVIR ≥ F2.…”
mentioning
confidence: 99%
“…(28) Park et al used the XL probe for TE in a Western population and compared results with MRE. (26) MRE detected any grade of fibrosis significantly better than TE, and magnetic resonance imaging (MRI)-PDFF was more accurate in detecting any grade of steatosis than CAP. However, the high costs and the expertise needed for accurate quantitative assessments currently limit the use of MRE and MRI-PDFF to specialized centers, and their clinical superiority needs to be proved outside the clinical trial setting.…”
Section: Assessment Of Graft Steatosismentioning
confidence: 95%
“…Park et al used the XL probe for TE in a Western population and compared results with MRE . MRE detected any grade of fibrosis significantly better than TE, and magnetic resonance imaging (MRI)–PDFF was more accurate in detecting any grade of steatosis than CAP.…”
Section: Assessment Of the Severity Of Liver Disease And Phtmentioning
confidence: 99%