Usefulness of Leucocyte Cell Population Data by Sysmex XN1000 Hematology Analyzer in Rapid Identification of Acute Leukemia

Mishra, Shruti; Chhabra, Gaurav; Padhi, Somanath; Mohapatra, Sonali; Panigrahi, Ashutosh; Sable, Mukund; Das, Prabodha Kumar

doi:10.1007/s12288-021-01488-9

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…1 The CPD parameters may be used to screen hematological and nonhematological disorders since they reflect certain morphological alterations in WBCs. Recent studies have found that CPD parameters may be putative biomarkers for the screening of various diseases, including viral infections, 2-4 malaria, 5,6 sepsis, 7,8 myelodysplastic syndrome, 9,10 acute leukemia, 11,12 and lymphoproliferative diseases. 13 It is important to establish the reference interval (RI) of CPD parameters for future studies of non-healthy individuals using CPD parameters.…”

Section: Introductionmentioning

confidence: 99%

Reference intervals of cell population data parameters in Sysmex XN‐Series and its patterns of changes from early adulthood to geriatric ages in South Korea

Choi,

Park,

Cho

et al. 2024

Int J Lab Hematology

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IntroductionCell population data (CPD) parameters may be putative biomarkers for the screening of various diseases including some infections and myelodysplastic syndrome. This study aimed to establish the age‐ and sex‐specific reference intervals (RIs) for the CPD parameters in the Korean population.MethodsThe reference population for the RIs of CPD parameters comprised 124 856 subjects aged 20–99 years. CPD parameters were obtained from Sysmex XN‐2000 (Kobe, Japan) datasets from 17 health promotion centers in 13 South Korean cities. We determined significant partitions for age and sex, and calculated RIs according to Clinical and Laboratory Standards Institute C28‐A3 guidelines.ResultsThe side scattered light intensity in the neutrophil area and the lymphocyte area did not require sex‐related partitioning except in those over the age of 50, among whom the lower limit (LL) and upper limit (UL) were lower in females. However, the side scattered light distribution width in the lymphocyte area required age‐ and sex‐related partitioning, in which LL and UL were higher in females. The LL and UL of the fluorescent light distribution width were higher in males in the neutrophil area and higher in females in the lymphocyte area, but age‐related partitioning was not required. The forward scattered light intensity in the neutrophil area, lymphocyte area, and monocyte area did not require age‐related partitioning in males.ConclusionThis study has determined comprehensive age‐ and sex‐specific RIs for CPD parameters, which could help to prove the clinical significance of these parameters in the Sysmex XN‐2000.

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Section: Introductionmentioning

confidence: 99%

Reference intervals of cell population data parameters in Sysmex XN‐Series and its patterns of changes from early adulthood to geriatric ages in South Korea

Choi,

Park,

Cho

et al. 2024

Int J Lab Hematology

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“…Additionally, the XN1000 analyzer also provides the cell population data (CPD) based upon the scatter position of the cells on the three positional axes, "X," "Y," and, "Z" representing the internal complexity or granularity, the fluorescence intensity or the immaturity, and the size of the cell respectively. The degree of heterogeneity of each cell population along the three‐axis is represented as "WX," "WY," and "WZ" 4–6 …”

Section: Introductionmentioning

confidence: 99%

“…The role of CPD and other research parameters in various malignant disorders such as acute leukemia and sepsis has been studied earlier 6–8 . However, there is a lack of information regarding its usefulness in the rapid screening of dengue fever.…”

Section: Introductionmentioning

confidence: 99%

“…The degree of heterogeneity of each cell population along the three-axis is represented as "WX," "WY," and "WZ". [4][5][6] The role of CPD and other research parameters in various malignant disorders such as acute leukemia and sepsis has been studied earlier. [6][7][8] However, there is a lack of information regarding its usefulness in the rapid screening of dengue fever.…”

mentioning

confidence: 99%

“…[4][5][6] The role of CPD and other research parameters in various malignant disorders such as acute leukemia and sepsis has been studied earlier. [6][7][8] However, there is a lack of information regarding its usefulness in the rapid screening of dengue fever. This study aimed to find the utility of HFLC and leucocyte CPD generated by the Sysmex XN-1000 analyzer in the rapid screening of dengue fever and its differentiation from the other causes of febrile illness.…”

mentioning

confidence: 99%

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Rapid screening of dengue fever using research parameters from new generation hematological analyzers

Chhabra

Das

Mishra

et al. 2021

Int J Lab Hematology

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Dengue is one of the common mosquito-borne diseases in tropical countries like India. The primary vector is female mosquitoes of the Aedes genus, principally by Aedes aegypti. The presenting symptoms may range from mild febrile illness to severe disease and overlap with other causes of infective febrile illness, including malaria, chikungunya, leptospirosis, Rickettsial diseases, and in the current pandemic, Covid-19 also. The serological examination based on the detection of dengue NS1 antigen or anti-dengue IgM antibodies is the method of choice for diagnosing dengue fever. However, the isolation of the virus remains the gold standard. 1

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Time-dependent changes in cell population data obtained using Sysmex XN-series hematology analyzer in bacterial infections

Kaneda,

Nagaoka,

Yoshida

et al. 2024

Journal of Infection and Chemotherapy

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Usefulness of Leucocyte Cell Population Data by Sysmex XN1000 Hematology Analyzer in Rapid Identification of Acute Leukemia

Cited by 4 publications

References 12 publications

Reference intervals of cell population data parameters in Sysmex XN‐Series and its patterns of changes from early adulthood to geriatric ages in South Korea

Reference intervals of cell population data parameters in Sysmex XN‐Series and its patterns of changes from early adulthood to geriatric ages in South Korea

Rapid screening of dengue fever using research parameters from new generation hematological analyzers

Time-dependent changes in cell population data obtained using Sysmex XN-series hematology analyzer in bacterial infections

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