Usefulness of Left Ventricular Diastolic Wall Motion Abnormality as an Early Predictor of Left Ventricular Dilation After a First Acute Myocardial Infarction

Persistent Regional Diastolic Dysfunction after Myocardial Ischemia and the Effect of Statin Treatment: Assessment with Two‐Dimensional Radial Strain Rate

“…With the help of this technique, we are able to more easily and reproducibly estimate global and regional strain and strain rate in comparison with Doppler‐derived strain and strain rate 14 . Although earlier studies suggested the possibility of the existence of regional diastolic impairment after an ischemic attack using color kinesis, 4,17–19 color kinesis is limited due to its low temporal resolution (20–30 frames/sec) and excessive dependence on two‐dimensional image quality. Moreover, given that STE can now achieve 80–100 frames/sec and that recent refinements of its offline analysis program have made it less dependent on two‐dimensional image quality, this technique can be considered to have special advantages over color kinesis.…”

“…Taken together, the pleiotropic effects of statin can somewhat explain the attenuation of regional diastolic dysfunction after an acute ischemia observed in the present study. Given the prognostic implication of regional diastolic functional abnormality, 18 statin administration possibly exerts a protective effect on myocardium at risk, with the regional diastolic dysfunction period minimized. This protective effect of statin is likely to be of special value for myocardial segments in which the occurrence of frequent episodes of angina attack is anticipated.…”

Evaluation of left ventricular diastolic function using color kinesis

“…[3][4][5][6] Previous clinical studies have demonstrated that analysis of diastolic CK images proves useful for objective assessment of LV diastolic dysfunction in patients with LV hypertrophy, [7][8][9] as well as regional LV fi lling abnormalities in patients with dilated cardiomyopathy (DCM) and severe mitral regurgitation. 10 Husic et al 11 reported that LV diastolic wall motion abnormality on CK images may be an early predictor of remodeling after acute myocardial infarction. In addition, the results of an animal CK study suggest that delayed regional fi lling can also be seen in patients undergoing dobutamine stress testing before systolic wall motion abnormalities are detected.…”

Taxol inhibits stretch-induced electrophysiological alterations in isolated rat hearts with acute myocardial infarction

“…Regional inhomogeneities in contractility, as well as mechanical restitution, have generally been regarded as foci for arrhythmias [1,2]. The arrhythmogenic effects of mechanical stress have been reported as stretch-induced arrhythmias (SIAs), which are facilitated by "mechanoelectric feedback" (MEF).…”