Usefulness of Lanoconazole (Astat^®) cream in the treatment of hyperkeratotic type tinea pedis. Comparative study of monotherapy and combination therapy with 10% Urea Ointment (Pastaron^®)

Abstract

Hyperkeratotic type tinea pedis is a refractory type of superficial dermatomycosis. Treatment for hyperkeratotic type tinea pedis is mainly with oral antimycotics, such as griseofulvin, and healing is generally considered to be difficult with only topical antimycotics. In this randomized comparative study, the usefulness of a topical application of 1% lanoconazole cream (Astat) monotherapy (group I) was compared with that of combination therapy with 1% lanoconazole cream and 10% urea ointment (Pastaron) (group II) in a series of patients with hyperkeratotic type tinea pedis. The clinical improvement rates (percentage of 'marked improvement' plus 'moderate improvement') was 70.0% in group I and 95.7% in group II. The fungal eradication rate was 5.0% in group I and 43.5% in group II after 4 weeks of treatment, and was 70.0% and 95.7% after 12 weeks of treatment, respectively. The usefulness rate (percentage of 'very useful' plus 'useful') was 70% in group I and 95.7% in group II. Both lanoconazole monotherapy and the combination therapy with 10% urea ointment were highly effective and safe. Both treatments should be recommended for patients with hyperkeratotic type tinea pedis for whom an oral treatment is not appropriate or for whom a sufficient improvement with oral medications cannot be expected.

[N(CH3)4]2[Mn(H2O)]3[Mo(CN)7]2⋅2 H2O: A New High Tc Cyano-Bridged Ferrimagnet Based on the [MoIII(CN)7]4− Building Block and Induced by Counterion Exchange

“…In this paper, we describe attempts to nondestructively determine the urea concentration in a cream formulation using Raman spectroscopy. Urea‐based creams are topical pharmaceuticals used for the treatment of many skin diseases, such as dermatitis,12 eczema,13 xerosis,14 hyperkeratotic type tinea pedis15 and recalcitrant verruca vulgaris 16. The British pharmacopoeial procedure for quantitatively analyzing a urea cream is a colorimetric method,17 which requires a great deal of sample derivatization; another method, hydrophilic interaction chromatography, is likewise time consuming for sample and mobile‐phase preparation 18, 19.…”

Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic‐type tinea pedis

“…As hyperkeratotic‐type tinea pedis creates remarkable keratinisation, topically applied antifungals do not penetrate the stratum corneum deep enough. Therefore, antifungal treatment is often unsuccessful when topical antifungal is usedas monotherapy 1–4 . For this reason, oral antifungals such as griseofulvin (GRF) have long been prescribed as the first choice of drug to treat this disease 4 …”

“…Therefore, antifungal treatment is often unsuccessful when topical antifungal is used as monotherapy. [1][2][3][4] For this reason, oral antifungals such as griseofulvin (GRF) have long been prescribed as the first choice of drug to treat this disease. 4 Because of its biocidal effects on trichophyton, terbinafine (TBF) is considered more useful than GRF or itraconazole (ITCZ) for hyperkeratotic-type tinea pedis.…”

Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis

“…As hyperkeratotic type tinea pedis creates remarkable keratinization, topically applied antifungals do not penetrate the stratum corneum deep enough. Therefore, antifungal treatment is often unsuccessful when topical antifungal is used alone 1–4 . For this reason, oral antifungals such as griseofulvin (GRF) have long been prescribed as the first choice of drug to treat this disease 4 …”

“…Therefore, antifungal treatment is often unsuccessful when topical antifungal is used alone. [1][2][3][4] For this reason, oral antifungals such as griseofulvin (GRF) have long been prescribed as the first choice of drug to treat this disease. 4 Because of its biocidal effects on Trichophyton, terbinafine (TBF) is considered more useful than GRF or itraconazole (ITCZ) for hyperkeratotic type tinea pedis.…”