Setting: The infection with Mycobacterium tuberculosis gives a delayed immune response, measured by the tuberculine skin test. We present a new technique for evaluation based on automatic detection and measurement of skin infrared emission. Design: 21 subjects (57.0±17.8 yr), (7/14, M/F) with suspected tuberculosis contact were examined with an IR thermal camera, 48 hours after skin injection. Results: In 15 subjects, IR analysis was positive for tuberculine test. Mean temperature of injection area was higher, around 1 ºC, for the positive group (36.0± 0.3 ºC positive group; 35.2±1.7 ºC negative group, p<0.001, Non parametric U Mann-Whitney Test). Conclusion: IR may represent an improved estimation of tuberculosis infection, given that it does not depend on reader variability and measures the increase of heat irradiation produced by the allergic tuberculine response. "NOTICE: this is the author's version of a work that was accepted for publication in . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Computer Methods and Programs in Biomedicine, vol.122, issue 2, (November 2015
Conclusion: IR may represent an improved estimation of tuberculosis infection,given that it does not depend on reader variability and measures the increase of heat irradiation produced by the allergic tuberculine response. 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64