Usefulness of Immunohistochemistry in the Diagnosis of Nodular Thyroid Disease

Zosin, Ioana; Cornianu, Mărioara; Golu, Ioana; Balaş, Melania

doi:10.4183/aeb.2007.437

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…This current result is in agreement with most other studies, which showed that CK-19 immunostaining was strong and diffuse in PTC specimens, and that there was either none or only weak immunostaining in benign lesions. 7,23–25…”

Section: Discussionmentioning

confidence: 99%

Combined staining for immunohistochemical markers in the diagnosis of papillary thyroid carcinoma: Improvement in the sensitivity or specificity?

Wang

Zhou

et al. 2013

J Int Med Res

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Section: Discussionmentioning

confidence: 99%

Combined staining for immunohistochemical markers in the diagnosis of papillary thyroid carcinoma: Improvement in the sensitivity or specificity?

Wang

Zhou

et al. 2013

J Int Med Res

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“…According to Zosin et al immunoreactivity for Cytokeratin-19 is even able to differentiate FVPTC from FTC and PTC from papillary hyperplasia (23). It has concomitantly a follicular architecture and nuclear features of PTC.…”

Section: Concurrent Positivity Of Markers In Different Combinationsmentioning

confidence: 99%

Application of immunohistochemical markers in the differential diagnosis of thyroid tumors

Siderova¹

2013

Acta Endo (Buc)

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Aim.To evaluate the expression of Galectin-3, Fibronectin-1, Cytokeratin-19 and HBME 1 in benign and malignant thyroid nodules and to assess their diagnostic value.Methods. Immunohistochemical analysis was performed on 59 surgically removed thyroid nodules, including 34 carcinomas (12 papillary, 2 tall cell variants, 3 lymph node metastases from papillary carcinoma, 5 follicular variants of papillary carcinoma (FVPTC), 3 anaplastic, 5 follicular and 4 Hürthle cell carcinomas), as well as 25 benign lesions (10 follicular adenomas, 4 Hürthle cell adenomas, 11 nodular goiters with surrounding normal thyroid tissue).Results. We found strong and diffuse Galectin-3 expression in all malignant lesions except for one case of FVPTC and one follicular carcinoma. Normal thyrocytes and the majority of the benign lesions were negative for all markers. Statistical analysis of each protein confirmed that Galectin-3 was the most sensitive (94%), followed by Cytokeratin-19 (88%). Fibronectin-1 and HBME 1 proved to be less sensitive (56% and 68%, respectively), but more specific (92% specificity for each of them). Coexpression of two or more proteins was restricted to carcinomas, while their concurrent absence was highly specific for benign lesions. Comparing the immunopositivity in follicular carcinoma versus adenoma we achieved 80% sen-sitivity for Galectin-3 and 100% specificity for HBME 1 . For distinguishing the Hürthle cell lesions, Fibronectin-1 turned out to be more sensitive than Galectin-3 and Cytokeratin-19.Conclusion. Our findings suggest that immunohistochemical panel consisting of Galectin-3, Cytokeratin-19, HBME 1 and Fibronectin-1 might contribute to differential diagnosis between malignant and benign thyroid nodules, including those with follicular architecture.

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Usefulness of Immunohistochemistry in the Diagnosis of Nodular Thyroid Disease

Cited by 2 publications

References 28 publications

Combined staining for immunohistochemical markers in the diagnosis of papillary thyroid carcinoma: Improvement in the sensitivity or specificity?

Combined staining for immunohistochemical markers in the diagnosis of papillary thyroid carcinoma: Improvement in the sensitivity or specificity?

Application of immunohistochemical markers in the differential diagnosis of thyroid tumors

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