Usefulness of High-Frequency Ultrasonography in the Diagnosis of Melanoma: Mini Review

Belfiore, Maria Paola; Reginelli, Alfonso; Russo, Anna; Russo, G; Rocco, Maria Paola; Moscarella, Elvira; Ferrante, Marilina; Sica, Antonello; Grassi, Roberto; Cappabianca, Salvatore

doi:10.3389/fonc.2021.673026

Cited by 14 publications

(10 citation statements)

References 46 publications

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“…7,26 It is also possible to measure the ultrasonographic thickness of melanoma, with a significantly similar correlation between the ultrasonographic value and the Breslow thickness using HFUS and UHFUS, and with a better correlation when compared with transducers of 7.5 MHz frequency, but with HFUS (20 MHz) it may be difficult to evaluate melanomas <2 mm of thickness. 14,27,28 A systematic review including 14 studies (1250 melanomas) also reported a good correlation between the two measurements. 29 Other studies reported the use of conventional ultrasound in the measurement of thickness and vascularitazion degree in melanoma and nonmelanoma skin cancers.…”

Section: Discussionmentioning

confidence: 79%

“…13 In vivo reflectance confocal microscopy, optical coherence tomography and high-frequency ultrasound (HFUS) 20 MHz are other non-invasive techniques for assessing melanoma. [14][15][16] HFUS and optical coherence tomography have been shown to be the most useful methods for evaluating the depth, however some studies report that they are not sufficiently accurate in the differential diagnosis between atypical nevus and thin melanoma. 9,16 Other techniques may help in differentiating melanoma from atypical naevi, such as dynamic markers based on blood perfusion fluctuations.…”

Section: Introductionmentioning

confidence: 99%

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Ultra‐High Frequency Ultrasound in Melanoma Management

Oranges

Janowska

Scatena

et al. 2022

J of Ultrasound Medicine

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Objectives-The main aim of this study is to evaluate the correspondence between the ultrasonographic thickness and the Breslow thickness in melanoma using ultra-high frequency ultrasound and the intra-and inter-operator repeatability in the ultrasonographic measurements of melanoma depth. Moreover, we propose a new protocol based on a combined ultrasonographichistopathological approach.Methods-We analyzed 27 melanomas in a population consisted of 27 patients (mean age 57.6 years, 51.8% males), who came at the Department of Dermatology (University of Pisa, Pisa, Italy) from April 2016 to March 2018 and had an ultrasonographic examination of a suspected lesion before the surgical removal using ultra-high frequency ultrasound (Vevo ® MD, Fujifilm, Visualsonics, Toronto, Canada; 70 MHz probe). B-mode images were analyzed by two skilled and blinded operators, and the maximum depth of the lesions was measured using a dedicated graphical user interface developed in Matlab R2016b (MathWorks Inc., Natick, MA), to obtain repetitive measurements.Results-All melanomas appeared as band-like or oval/fusiform shaped hypoechoic inhomogeneous lesions. We observed an excellent agreement between the Breslow thickness of melanomas and the ultrasonographic thickness, as well as a reduced intra-and inter-operator variability in the ultrasonographic measurements of melanoma depth.Conclusions-We propose a ultrasonographic-histopathological protocol which may help clinicians to reduce the diagnostic delay, improve prognosis and survival rates, perform a surgical excision with negative margins, and reduce the variability in the assessment of Breslow thickness.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Ultra‐High Frequency Ultrasound in Melanoma Management

Oranges

Janowska

Scatena

et al. 2022

J of Ultrasound Medicine

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“…The ultrasound study of neoplasms is used for many organs and tissues, from skin [17], tyroid [18], and salivary glands [19], to breasts [20], lungs [21], and the pancreas [22]. It is obvious how the differences in the individual anatomical areas translate into differences in the ultrasound appearance, such that it is necessary to use different evaluation parameters compared to those used for routine.…”

Section: Discussionmentioning

confidence: 99%

High-Definition Ultrasound Characterization of Squamous Carcinoma of the Tongue: A Descriptive Observational Study

Stasio

Montella

Romano

et al. 2022

Cancers

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High-definition ultrasonography is a diagnostic tool that uses sound echoes to produce images of tissues and organs. In the head and neck region, ultrasounds have been used to diagnose different types of lesions. The intraoral approach was shown to be a real-time, non-invasive way to characterize oral lesions. The tongue is the most often examined region because of its accessibility. This observational study aimed to describe the qualitative characteristics of tongue squamous cell carcinoma images obtained with high-definition intraoral ultrasound by comparing them with the corresponding histopathological sample. Twenty patients were enrolled in this study. The scans of the lesions were carried out with an 18 MHz linear ultrasound probe following the long axis of the lesion. For each lesion, five frames were selected, on which descriptive analysis was performed. A histological sample was taken and then compared to the ultrasonographic acquisition. The sonographic appearance of the tissue layers has a good correlation between ultrasound and histological morphology, and it was easy to distinguish the tumor from the homogenous composition of the tongue tissues. Furthermore, a correlation between the structure by section and pattern of tumor margin features by ultrasound was obtained. Intraoral ultrasonography appears to be a promising technique in the non-invasive characterization of tongue squamous cell carcinoma. Further studies will be needed to improve the technique in terms of ergonomics and repeatability.

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“…One such modality is high frequency ultrasound (HFUS), or ultra-high frequency ultrasound (ultra-HFU). Because of the high resolution of superficial structures, studies have shown that HFUS can determine the Breslow index in a significant number of patients, providing important clinical information previously only obtained via biopsy [33,34]. Another recently developed approach is the use of multispectral imaging for the diagnosis of melanoma.…”

Section: Current Role Of Medical Imagingmentioning

confidence: 99%

Translating Molecules into Imaging—The Development of New PET Tracers for Patients with Melanoma

et al. 2022

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Melanoma is a deadly disease that often exhibits relentless progression and can have both early and late metastases. Recent advances in immunotherapy and targeted therapy have dramatically increased patient survival for patients with melanoma. Similar advances in molecular targeted PET imaging can identify molecular pathways that promote disease progression and therefore offer physiological information. Thus, they can be used to assess prognosis, tumor heterogeneity, and identify instances of treatment failure. Numerous agents tested preclinically and clinically demonstrate promising results with high tumor-to-background ratios in both primary and metastatic melanoma tumors. Here, we detail the development and testing of multiple molecular targeted PET-imaging agents, including agents for general oncological imaging and those specifically for PET imaging of melanoma. Of the numerous radiopharmaceuticals evaluated for this purpose, several have made it to clinical trials and showed promising results. Ultimately, these agents may become the standard of care for melanoma imaging if they are able to demonstrate micrometastatic disease and thus provide more accurate information for staging. Furthermore, these agents provide a more accurate way to monitor response to therapy. Patients will be able to receive treatment based on tumor uptake characteristics and may be able to be treated earlier for lesions that with traditional imaging would be subclinical, overall leading to improved outcomes for patients.

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Usefulness of High-Frequency Ultrasonography in the Diagnosis of Melanoma: Mini Review

Cited by 14 publications

References 46 publications

Ultra‐High Frequency Ultrasound in Melanoma Management

Ultra‐High Frequency Ultrasound in Melanoma Management

High-Definition Ultrasound Characterization of Squamous Carcinoma of the Tongue: A Descriptive Observational Study

Translating Molecules into Imaging—The Development of New PET Tracers for Patients with Melanoma

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