Usefulness of handheld electroretinogram system for diagnosing blue-cone monochromatism in children

Haseoka, Takashi; Inagaki, Risako; Kurata, Kentaro; Arai, Shinji; Takagi, Yuri; Suzuki, Hiroyoshi; Hikoya, Akiko; Nishimura, Kasumi; Hotta, Yoshihiro; Sato, M.

doi:10.1007/s10384-020-00782-9

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…Figure 2 illustrates the device and example waveforms. Many publications have emerged reporting its use in diverse conditions including diabetic retinopathy, a range of inherited retinal diseases, birdshot chorioretinopathy, glaucoma, idiopathic intracranial hypertension, and others [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: Advances In Devicesmentioning

confidence: 99%

Visual electrophysiology and “the potential of the potentials”

Mahroo

2023

Eye

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Visual electrophysiology affords direct, quantitative, objective assessment of visual pathway function at different levels, and thus yields information complementary to, and not necessarily obtainable from, imaging or psychophysical testing. The tests available, and their indications, have evolved, with many advances, both in technology and in our understanding of the neural basis of the waveforms, now facilitating more precise evaluation of physiology and pathophysiology. After summarising the visual pathway and current standard clinical testing methods, this review discusses, non-exhaustively, several developments, focusing particularly on human electroretinogram recordings. These include new devices (portable, non-mydiatric, multimodal), novel testing protocols (including those aiming to separate rod-driven and cone-driven responses, and to monitor retinal adaptation), and developments in methods of analysis, including use of modelling and machine learning. It is likely that several tests will become more accessible and useful in both clinical and research settings. In future, these methods will further aid our understanding of common and rare eye disease, will help in assessing novel therapies, and will potentially yield information relevant to neurological and neuro-psychiatric conditions.

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Section: Advances In Devicesmentioning

confidence: 99%

Visual electrophysiology and “the potential of the potentials”

Mahroo

2023

Eye

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“…These conditions make the recording of the flicker ERGs easier and more convenient for the patients and clinicians. Therefore, flicker ERGs recorded with the RETeval system have been used not only to evaluate retinal diseases, e.g., central retinal vein occlusion (CRVO) [ 3 , 4 ], blue-cone monochromatism (BCM) [ 5 ], and retinopathy of prematurity (ROP) [ 6 ], but also for the screening of retinal diseases, e.g., for diabetic retinopathy [ 7 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

et al. 2023

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Purpose To determine the factors significantly associated with the amplitudes and implicit times of the flicker electroretinograms (ERGs) recorded with the RETeval system by analyzing the comprehensive data obtained during a health checkup screening. Methods Flicker ERGs were recorded with the RETeval system from 373 individuals who had a normal fundus and optical coherence tomography images. The sex, age, anthropometric, ophthalmologic, and hematologic data were collected from all participants who were 40- to 89-years-of-age. Univariable and multivariable linear mixed effects regression analyses were performed to identify factors that were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Results Univariable linear mixed effects regression analysis showed significant correlations between the implicit times and the best-corrected visual acuity, the age, the axial length, the blood sugar level, and the blood urea nitrogen level. Analyses by multivariable linear mixed effects regression identified that the axial length (β = 0.28), the age (β = 0.24), and the blood sugar level (β = 0.092) were three independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariable linear mixed effects regression analysis also showed significant correlations between the amplitudes of the RETeval flicker ERGs and the age, the platelet count, and the creatinine level. Multivariable linear mixed effects regression models identified the age (β = -0.092), the platelet count (β = 0.099), and the creatinine level (β = -0.12) as three independent factors that were significantly correlated with the amplitudes of the RETeval flicker ERGs. However, the smoking habits, body mass index, and the blood pressure were not significantly correlated with either the implicit times or amplitudes of the RETeval flicker ERGs. Conclusions Our results indicate that the age and some ophthalmologic and hematologic findings but not the anthropometric findings were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Thus, clinicians should remember these factors when analyzing the RETeval flicker ERGs.

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“…Therefore, icker ERGs utilizing RETeval system has been applied not only to evaluate retinal diseases; e.g. central retinal vein occlusion (CRVO) 3,4 , blue-cone monochromatism (BCM) 5 , and retinopathy of prematurity (ROP) 6 , but also for the screening of retinal diseases, e.g., for diabetic retinopathy [7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

Inooka

Kominami

Yasuda

et al. 2022

Preprint

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The purpose of this study was to determine the ocular, sex- and age-specific, anthropometric, and hematologic factors that affect the implicit times and amplitudes of the flicker ERGs recorded with the RETeval system from individuals 40- to 89-years-of-age. Flicker ERGs were recorded with the RETeval system from 330 individuals who had normal fundus and OCT images. Univariate and multivariate regression analyses were performed to identify factors associated with the implicit times and amplitudes of the RETeval flicker ERGs. Univariate regression analyses showed significant correlations between the implicit times and the BCVA, age, axial length, blood sugar level, and BUN in both eyes. Multivariate regression analyses identified age and axial length as two independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariate regression analyses also showed significant correlations between the amplitudes and age, platelet count, HDL level, and creatinine level in both eyes. However, smoking habits, body mass index, and blood pressure were not correlated with the RETeval flicker ERGs. We conclude that age and some ophthalmologic and hematologic findings except for anthropometric findings were suggested to significantly affect the measurements of the RETeval flicker ERGs.

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Usefulness of handheld electroretinogram system for diagnosing blue-cone monochromatism in children

Cited by 6 publications

References 19 publications

Visual electrophysiology and “the potential of the potentials”

Visual electrophysiology and “the potential of the potentials”

Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

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