Usefulness of finger blood flow during exercise as a marker of functionally significant coronary heart disease

Qureshi, Ehtasham; Diamond, George A.; Chouraqui, Pierre; Saef, Jerold; Reed, George E.; Armenia, Amy; Rozanski, Alan

doi:10.1016/s0002-9149(02)02605-x

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Many patients with coronary artery disease have paradoxical peripheral vasoconstriction during exercise rather than the vasodilation that constitutes the normal peripheral thermoregulatory vascular response to exercise. 21,22 Could impaired heat regulation in patients with peripheral vasoconstriction cause impaired exercise tolerance and sensations of dyspnea? Alternatively, the development of coronary artery disease is associated with inflammatory proteins that can potentially induce somatic symptoms, such as malaise and fatigue.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Dyspnea in Patients Referred for Cardiac Stress Testing

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Dyspnea in Patients Referred for Cardiac Stress Testing

et al. 2005

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“…It was already shown that patients with coronary heart disease demonstrate changes in cutaneous microcirculation and a decrease in cutaneous blood mass [3,[8][9][10][11]. One of the suggested predictors of risk for cardiovascular disease is Endothelial Function which is based on sensitivity to long-acting nitrates and vasoactive drugs.…”

Section: Introductionmentioning

confidence: 99%

Peripheral microcirculatory hemodynamic changes in patients with myocardial ischemia

Ovadia‐Blechman

Avrahami

Weizman-Shammai

et al. 2015

Biomedicine & Pharmacotherapy

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“…For example, those patients with coronary artery disease have detectable reduction in blood flow in finger arteries (Qureshi et al. ). Assessment of finger artery blood flow using peripheral arterial tonometry is capable of detecting endothelial dysfunction in patients with hypertension, hyperlipidemia, and diabetes mellitus (Kuvin et al.…”

Section: Introductionmentioning

confidence: 99%

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

et al. 2013

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Chronic renal failure (CRF) is associated with hypertension and concomitant endothelial dysfunction, enhanced vasoconstriction, and nitric oxide synthase (NOS) dysfunction. Vascular function in patients is assessed in peripheral extremity arteries like the finger arteries, whereas animal studies often use the centrally located aorta. Therefore, we examined whether peripheral tail artery and aortic NOS function are differentially regulated by blood pressure in rats with CRF. Using wire myography, arterial function was assessed in 16-week-old Sprague-Dawley rats that were subjected to 5/6 nephrectomy (Nx; arterial ligation model) 8 weeks earlier or non-Nx (control) rats. In aortas from Nx rats, endothelial-dependent vasorelaxation response to acetylcholine (ACh) was blunted and there was enhancement of phenylephrine (PE)-mediated vasoconstriction. Inversely, tail arteries from Nx rats had no change in endothelial function and reduced response to PE. Studies where arterial segments were incubated with the nonspecific NOS inhibitor, L-NAME, showed that Nx reduced NOS function in the aorta but increased NOS function in tail artery for both ACh and PE responses. Furthermore, the observed alterations in NOS function in both aorta and tail artery were abolished when mean arterial blood pressure, as assessed by telemetry, was maintained at normal levels in the 5/6 Nx rats using triple therapy: hydralazine (30 mg/kg per day), hydrochlorothiazide (10 mg/kg per day), and reserpine (0.5 mg/kg per day). In conclusion, differential changes of NOS function in central versus peripheral arteries in CRF are dependent upon hypertension.

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Usefulness of finger blood flow during exercise as a marker of functionally significant coronary heart disease

Cited by 6 publications

References 12 publications

Prognostic Significance of Dyspnea in Patients Referred for Cardiac Stress Testing

Prognostic Significance of Dyspnea in Patients Referred for Cardiac Stress Testing

Peripheral microcirculatory hemodynamic changes in patients with myocardial ischemia

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

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