Usefulness of Exercise-Induced Changes in Plasma Levels of Brain Natriuretic Peptide in Predicting Right Ventricular Contractile Reserve After Repair of Tetralogy of Fallot

Ishii, Haruka; Harada, Kenji; Toyono, Manatomo; Tamura, Masazumi; Takada, Goro

doi:10.1016/j.amjcard.2005.01.079

Cited by 47 publications

(51 citation statements)

References 27 publications

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“…15,16,23-25 A significant correlation was seen between RV hemodynamic parameters and concentration of neurohumoral markers in pediatric patients with RV overload. 15, 17 Ishii et al 20 showed that BNP in patients with TOF is significantly higher than in healthy control subjects. Previous reports found increased secretion of neurohumoral markers even in asymptomatic patients after repair for TOF, 4,17 which is confirmed by the present findings.…”

Section: Discussionmentioning

confidence: 99%

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N-terminal pro-Brain Natriuretic Peptide as a Predictor of Reoperation in Children With Surgically Corrected Tetralogy of Fallot

Hirono

Sekine

Shiba

et al. 2014

Circ J

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Section: Discussionmentioning

confidence: 99%

“…It was designated mild if retrograde flow was localized to the pulmonary valve; moderate if it started from the main pulmonary artery; and severe if it was detected also in the branch pulmonary arteries. 20 …”

Section: Echocardiographymentioning

confidence: 99%

N-terminal pro-Brain Natriuretic Peptide as a Predictor of Reoperation in Children With Surgically Corrected Tetralogy of Fallot

Hirono

Sekine

Shiba

et al. 2014

Circ J

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“…In contrast, only limited studies have addressed RV contractile reserve and these have predominantly been in the setting of biventricular failure [7,[11][12][13][14][15][16][17]. Specifically, assessment of RV contractile reserve using dobutamine stress has not been investigated in PAH.…”

Section: Introductionmentioning

confidence: 99%

Dobutamine stress for evaluation of right ventricular reserve in pulmonary arterial hypertension

et al. 2014

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Right ventricular contractile response to pharmacological stress in pulmonary arterial hypertension (PAH) has not been characterised. We evaluated right ventricular contractile reserve in adults with PAH using dobutamine stress echocardiography.16 PAH patients and 18 age-matched controls underwent low-dose dobutamine stress echocardiography. Contractile reserve was assessed by the change (Δ; peak stress minus rest value) in tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular systolic velocity (S′). A subgroup of 13 PAH patients underwent treadmill cardiopulmonary exercise testing for peak oxygen uptake (V′O 2 peak).At rest, TAPSE and S′ were reduced in the PAH group compared with controls (1.7±0.4 versus 2.4±0.2 cm and 9.7±2.6 versus 12.5±1.2 cm·s −1 , respectively; p<0.05). Contractile reserve was markedly attenuated in PAH compared to controls (ΔTAPSE 0.1±0.2 versus 0.6±0.3 cm and ΔS′ 4.6±2.8 versus 11.2±3.6 cm·s −1 ; p<0.0001). In the sub-group of PAH patients with preserved right ventricular systolic function at rest, contractile reserve remained depressed compared to controls. V′O 2 peak was significantly correlated with ΔS′ (r=0.87, p=0.0003) and change in stroke volume (r=0.59, p=0.03).Dobutamine stress can reveal sub-clinical reduction in right ventricular contractile reserve in patients with PAH. A correlation with exercise capacity suggests potential clinical value beyond resting measurements. @ERSpublications Dobutamine-induced right ventricular contractile reserve is impaired in PAH and correlates with exercise capacity

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“…Normal value of RV-dP/dt is reported to be 255 AE 18 mmHg/s [93]. RV-dP/dt is also shown to be helpful in the assessment of congenital heart disease [94]. Similar to the LV, RV-dP/dt is affected by changes in loading condition.…”

Section: Mpimentioning

confidence: 95%

Assessment of Ventricular-Vascular Function by Echocardiography

Toyono

2014

Congenital Heart Disease

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Reliable assessment of ventricular function is an essential for management of patients with heart disease. Noninvasive echocardiographic evaluation is indispensable for repeated assessment of ventricular function in the clinical setting. Alterations of left and right ventricular geometry and loading conditions are the property of congenital heart disease; therefore, quantitative assessment of ventricular function is technically challenging. Systolic ventricular function is pump activity for the generation of an adequate cardiac output with filling pressure as low as possible. A wide variety of different echocardiographic parameters and indices are developed for the assessment of systolic ventricular function; however, no single parameter adequately provides all the necessary information. One should integrate information from different parameters to comprehensively describe systolic function. Echocardiographic assessment of diastolic function is based on Doppler method of mitral inflow and the pulmonary veins with supplemental assessment by tissue Doppler, strain, and strain rate. Although several indices are available, no single indices adequately evaluate diastolic function. Therefore, a comprehensive examination is mandatory as well as in systolic ventricular function. This chapter will discuss traditional and newer echocardiographic techniques for the evaluation of ventricular function and, in addition, vascular function in patients with congenital heart disease.

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Usefulness of Exercise-Induced Changes in Plasma Levels of Brain Natriuretic Peptide in Predicting Right Ventricular Contractile Reserve After Repair of Tetralogy of Fallot

Cited by 47 publications

References 27 publications

N-terminal pro-Brain Natriuretic Peptide as a Predictor of Reoperation in Children With Surgically Corrected Tetralogy of Fallot

N-terminal pro-Brain Natriuretic Peptide as a Predictor of Reoperation in Children With Surgically Corrected Tetralogy of Fallot

Dobutamine stress for evaluation of right ventricular reserve in pulmonary arterial hypertension

Assessment of Ventricular-Vascular Function by Echocardiography

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