Usefulness of ethomidate in patients with Cushing syndrome with severe arterial hypertension and hypopotassemia

Castilla, Carolina; Amuedo, F. Rodríguez; Martínez, Antonio Morales; Siguero, Juan Pedro López; Aedo, M.J. Martínez; Manso, G. Milano

doi:10.1016/j.medine.2016.05.005

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…However, this review contained only three pediatric patients, without a consistent dose (6 year-old male, 0.03 mg/kg/hour, titrated to 0.08 mg/kg/hour; 14 year-old female, 3-3.5 mg/hour; 17 year-old female, 10 mg bolus then 2.5 mg/hour) ( 8 , 9 , 10 ), and no infant patients. There is only one report about the use of etomidate in a 14-month old infant who received etomidate for five days at an infusion rate of 0.03 mg/kg/hour ( 11 ). In our case, etomidate was administered as a 3-mg (0.3 mg/kg) bolus for induction and then as a continuous infusion at 0.03 mg/kg/hour.…”

Section: Discussionmentioning

confidence: 99%

Using Etomidate in a Two-month-old Infant with Cushing Syndrome due to Adrenocortical Carcinoma

Kwon¹,

Choi²,

Jung³

et al. 2022

Jcrpe

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Cushing syndrome (CS) is a rare disease caused by hypercortisolemia. Although surgical treatment is the first-line treatment in CS, the appropriate medication for the patient’s condition should be selected when medical treatment is needed. Etomidate is an adrenal-blocking drug used to treat CS and the most suitable for severe hypercortisolemia and adrenocortical carcinoma (ACC), due to cardiovascular stability and an anti-tumorigenic effect. However, its use and safe recommended dosage in infants with CS is unreported. Here we describe the case of a 2-month-old girl treated with etomidate for CS caused by ACC. Even though radical mass excision was performed, severe hypercortisolemia persisted, resulting from metastatic lesions in the liver, and medical treatment was considered. The etomidate doses, no bolus dose and infusion rate of 0.03 mg/kg/hour, may be an appropriate dose for severe hypercortisolemia in infants. This case will help determine future treatment strategies for similar cases in infants.

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