Usefulness of Endometrial Aspiration Cytology for the Preoperative Diagnosis of Ovarian Carcinoma

Jobo, Toshiko; Masahide, Arai; Hiroaki, Iwaya; Kato, Yoshiki; Ohno, Eiji; Kuramoto, Hiroyuki

doi:10.1159/000330960

Cited by 19 publications

(31 citation statements)

References 8 publications

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“…13 In many of our cases, extragenital malignant cells appeared between the normal endometrial cells, and no cytologic similarity was seen. In addition, most of the extragenital malignant cell groups were relatively small and solitary.…”

Section: Discussionmentioning

confidence: 60%

“…12 According to Jobo et al, the positive rate of endometrial aspiration cytology was 100% in patients with endometrial invasion and 15.9% in cases without invasion among preoperative patients with ovarian carcinoma. 13 These results suggest that endometrial aspiration cytology is more effective than cervical cytology for detecting ovarian cancer cells. Endometrial aspiration cytology has also been suggested to be more effective than endometrial biopsies because endometrial smears can detect ovarian cancer cells without endometrial invasion, while endometrial biopsies detect ovarian cancer tissues only when endometrial invasion is found.…”

Section: Discussionmentioning

confidence: 90%

“…9 There have been few reports in the Englishlanguage literature on extrauterine malignancies detected by endometrial aspiration cytology, and most such reports are related to ovarian cancer. [11][12][13][14] Takashina et al reported 19.3% of their cases to have cervicovaginal smears positive for ovarian cancer cells, while 41.9% of the endometrial aspiration smears they analyzed were positive in 114 preoperative patients with ovarian cancer. 12 According to Jobo et al, the positive rate of endometrial aspiration cytology was 100% in patients with endometrial invasion and 15.9% in cases without invasion among preoperative patients with ovarian carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…3,9 In endometrial aspiration cytology, the fallopian tube also seems to be an important pathway through which ovarian cancer cells appear because endometrial aspiration cytology can be positive without endometrial invasion, and the positive rate increases when ascites and/or peritoneal carcinomatosis are found. 12,13 Regarding extragenital malignancies, Miyagi et al reported 16 cases of gastric cancer detected by endometrial aspiration cytology. In 9 patients, adenocarcinoma cells were present in both the cervical and endometrial aspiration cytology specimens.…”

Section: Discussionmentioning

confidence: 99%

“…3,9 However, few reports have been published on endometrial smears concerning extrauterine malignant cells, especially extragenital ones. [10][11][12][13][14] Endometrial aspiration cytology has been used in previous reports, [10][11][12][13][14] and the positive rate of extrauterine malignant cells is higher for endometrial aspiration smears than for cervical smears. 12,13 One of the routes by which extrauterine carcinoma cells move to the Endometrial scraping smears, because of their simplicity and accuracy, are useful for detecting extragenital malignant cells that enter the uterine cavity.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Endometrial Scraping Cytology in Women with Extragenital Malignancies

Okadome¹,

Saito²,

Tsuji³

et al. 2006

Acta Cytologica

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Endometrial Scraping Cytology in Women with Extragenital Malignancies

Okadome¹,

Saito²,

Tsuji³

et al. 2006

Acta Cytologica

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Surgical staging of early invasive epithelial ovarian tumors

Leblanc¹,

Querleu²,

Narducci³

et al. 2000

Semin. Surg. Oncol.

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Early stage epithelial ovarian carcinoma is defined pathologically as a tumor strictly limited to one or both ovaries without any extra‐ovarian disease (i.e., Stage IA or B of the International Federation of Gynecology and Obstetrics (FIGO) classification). This diagnosis can be obtained only after an exhaustive surgical staging procedure, performed as soon as the diagnosis of epithelial invasive ovarian carcinoma is established. This staging surgery currently encompasses a peritoneal cytology, the thorough inspection of all the visceral and parietal peritoneal surfaces with biopsy of any abnormality, total abdominal hysterectomy and bilateral salpingo‐oophorectomy (TAH + BSO), random peritoneal biopsies, omentectomy, appendectomy and bilateral pelvic and para‐aortic lymphadenectomies, up to the left renal vein. The results of this staging procedure and its indications are discussed. In all of the cases, the radical removal of the pathologic adnexa is indicated, along with the complete peritoneal and retroperitoneal staging. While fertility‐sparing surgery (avoiding hysterectomy and contralateral adnexectomy, if possible) seems to be safe for young women, a TAH + BSO is the rule for the others. Adjuvant chemotherapy can be omitted in well‐differentiated tumors with a negative staging operation, but currently it remains indicated in all other cases. Indeed, the ultimate goal in early stage ovarian carcinoma is to not impair by inadequate management the high chance of a cure. Semin. Surg. Oncol. 19:36–41, 2000. © 2000 Wiley‐Liss, Inc.

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Positive endometrial cytology associated with primary gastric adenocarcinomas: clinical and cytopathologic findings in 16 patients

et al. 2000

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Background. Routine endometrial cytology occasionally includes malignant cells of extra-genital origin. We carried out this study to examine both the clinical and the cytopathologic characteristics of patients with positive endometrial cytology associated with gastric cancer. Methods. Sixteen patients whose endometrial smears contained malignant cells derived from gastric adenocarcinoma were studied. The patients' clinical symptoms, clinical courses, and cytologic and pathological findings were analyzed. Results. Among the 16 patients, 5 showed positive endometrial cytology prior to the initial treatment of gastric cancer, but after its diagnosis; 8 patients were being examined for relapse of gastric cancer; and, in the remaining 3 patients, the endometrial cytology led to the diagnosis of gastric cancer. Eleven patients had some clinical signs or symptoms, including abnormal vaginal discharge. Two patients were positive for serum carcinoembryonic antigen (CEA), while carbohydrate antigen (CA)125 was positive in 5 patients. The histological types of the primary gastric lesions were poorly differentiated adenocarcinoma (including signet ring cell adenocarcinoma) in 14 patients, and moderately differentiated tubular adenocarcinoma in 2 patients. Signet ring cells were observed on endometrial cytology in 12 patients. Four patients showed tumor diathesis on the smears. Metastatic lesions in the uterus were histologically confirmed in 5 patients. All 16 patients died as a result of peritoneal carcinomatosis within 12 months of the positive endometrial smears. Conclusion.Examination of routine reproductive tract smears, especially endometrial cytology, presents gynecologists with the opportunity to identify patients with gastric adenocarcinoma cells in the uterus and/or peritoneal cavity.

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Usefulness of Endometrial Aspiration Cytology for the Preoperative Diagnosis of Ovarian Carcinoma

Cited by 19 publications

References 8 publications

Endometrial Scraping Cytology in Women with Extragenital Malignancies

Endometrial Scraping Cytology in Women with Extragenital Malignancies

Surgical staging of early invasive epithelial ovarian tumors

Positive endometrial cytology associated with primary gastric adenocarcinomas: clinical and cytopathologic findings in 16 patients

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