Usefulness of elevated levels of soluble vascular cell adhesion molecule-1 in predicting in-hospital prognosis in patients with unstable angina pectoris

Rallidis, Lοukianos S.; Gika, Helen I.; Zolindaki, Maria; Xydas, T.; Paravolidakis, Konstantinos; Velissaridou, Aggeliki H.

doi:10.1016/j.amjcard.2003.07.029

Cited by 26 publications

(15 citation statements)

References 18 publications

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“…Serum levels of IL-6 have been shown to predict adverse outcomes, such as subsequent myocardial infarction and sudden death, in patients with CAD [4,5]. However, the diagnostic value of cellular adhesion molecules (CAMs) in the risk assessment in patients with CAD has not been fully established yet, as the findings on their usability to predict cardiovascular risk are inconsistent [6][7][8][9].…”

Section: Introductionmentioning

confidence: 98%

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Fan

Hua

et al. 2011

Cell Biochem Biophys

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Inflammatory responses are an important element in the atherosclerotic process. Therefore, inflammatory markers can potentially serve as predictors of cardiovascular risk. However, the existing data are limited and controversial. We conducted a prospective cohort study with 263 patients with first acute ST-segment elevation myocardial infarction (STEMI) who were admitted to our Hospital within 6 h after the symptoms onset. Clinical data were recorded and serum admission levels of interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble P-selectin (sP-selectin) were determined. The patients were then followed up for 3 years to document cardiovascular mortality. During the follow-up, 34 patients died from cardiovascular causes. The admission levels of IL-6 were significantly higher in these patients, whereas sICAM-1, sVCAM-1, and sP-selectin were comparable between these and the survived patients. The Kaplan-Meier plots revealed a significant increase in cardiovascular mortality with increasing levels of IL-6 (P = 0.0002, χ(2) test). The logistic regression analysis indicated that IL-6 was an independent predictor for cardiovascular mortality. To conclude, our findings indicate that elevated admission levels of IL-6, but not soluble adhesion molecules, provide valuable information for risk assessment of long-term cardiovascular mortality in patients with STEMI.

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Section: Introductionmentioning

confidence: 98%

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Fan

Hua

et al. 2011

Cell Biochem Biophys

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“…Patients with inhospital adverse coronary events are more likely to have higher admission levels of sVCAM-1; this association is independent of CRP. 30 In a prospective study of patients with NSTEMI, sVCAM-1 levels were significantly higher at presentation in patients who had a major adverse cardiovascular event at 6 months. 31 These initial studies suggest that sVCAM-1 may be a useful marker to predict medium-to long-term risk in patients with ACS.…”

Section: Armstrong Et Al Inflammatory Biomarkers In Acs E153mentioning

confidence: 99%

Inflammatory Biomarkers in Acute Coronary Syndromes

2006

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“…Soluble VCAM-1 levels shown to predict atherosclerotic complications in diabetic patients; may indicate risk of future cardiac events in ACS patients [104,105]. E-selectin Upregulated in angiogenesis [36].…”

Section: Adheres To Inflammatory Cells and Allows Their Transmigrationmentioning

confidence: 99%

Angiogenesis and oxidative stress: Common mechanisms linking psoriasis with atherosclerosis

Armstrong

Voyles

Armstrong

et al. 2011

Journal of Dermatological Science

145

131

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Usefulness of elevated levels of soluble vascular cell adhesion molecule-1 in predicting in-hospital prognosis in patients with unstable angina pectoris

Cited by 26 publications

References 18 publications

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Inflammatory Biomarkers in Acute Coronary Syndromes

Angiogenesis and oxidative stress: Common mechanisms linking psoriasis with atherosclerosis

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