Usefulness of early lung ultrasound in acute mild–moderate acute bronchiolitis. A pilot study

Garrote, Elia Zoido; Aparicio, Cristina; Villarroel, Constanza Camila Torrez; García, Antonio Pedro Vega; Fontan, M; Erroz, Ignacio Oulego

doi:10.1016/j.anpede.2018.03.004

Cited by 9 publications

(30 citation statements)

References 24 publications

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“…Like other diffuse inflammatory lung diseases, such as bronchiolitis and "adult" acute RDS (ARDS), dependent lung zones are the most affected in BPD. Importantly, LUS scores have also shown promising results in predicting outcomes of these conditions [33][34][35][36]. The lack of assessment of posterior lung zones may explain the lower predictive value of early LUS in the aforementioned studies compared with our results.…”

Section: Discussioncontrasting

confidence: 57%

“…More importantly, to date the correlation between LUS findings and lung pathology in BPD has not been stablished. Similar LUS scoring systems have been successfully used in disparate lung diseases such as neonatal RDS, ARDS, pneumonia, or bronchiolitis [ 27 , 33 , 34 , 39 , 40 ]. Although this fact may confirm the validity of the technique in predicting outcomes, the diversity of diseases detected with this method leaves the clinician questioning how early LUS findings are tied to the pathogenesis of BPD.…”

Section: Discussionmentioning

confidence: 99%

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Early assessment of lung aeration using an ultrasound score as a biomarker of developing bronchopulmonary dysplasia: a prospective observational study

et al. 2020

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The objective of this study was to assess the predictive value of a lung ultrasound (LUS) score in the development of moderate-severe bronchopulmonary dysplasia (sBPD). This was a prospective observational diagnostic accuracy study in a third-level neonatal intensive care unit. Preterm infants with a gestational age below 32 weeks were included. A LUS score (range 0-24 points) was calculated by assessing aeration semiquantitatively (0-3 points) in eight lung zones on the 7th day of life (DOL) and repeated on the 28th DOL. ROC curves and logistic regression were used for analysis. Forty-two preterm infants were included. The LUS on the 7th DOL had an area under the receiver operating characteristic curve (AUROC) of 0.94 (95% CI: 0.87-1) for the prediction of sBPD (optimal cutoff of ≥8 points: sensitivity 93%, specificity 91%). The LUS score was independently associated with sBPD [OR 2.1 (95% CI: 1.1-3.9), p = 0.022, for each additional point in the score]. Conclusions: Lung aeration as assessed by LUS on the 7th DOL may predict the development of sBPD.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Early assessment of lung aeration using an ultrasound score as a biomarker of developing bronchopulmonary dysplasia: a prospective observational study

et al. 2020

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“…We also found that bronchospasm may cause additional respiratory distress in children and not be apparent on lung ultrasound. This finding is somewhat at odds with Özkaya et al but is consistent with Zoido Garrote et al [ 6 , 20 ]. Interestingly, bovids do not get asthma, although they can develop chronic cough in response to dusty environments following RSV infection.…”

Section: Discussionsupporting

confidence: 88%

Validating a bovine model for lung ultrasound of bronchiolitis

et al. 2022

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Purpose Bronchiolitis is a very common acute lung disease in infants caused commonly by respiratory syncytial virus (RSV). Point-of-care lung ultrasound is increasingly used in clinical care but proof that ultrasound reflects histological disease is lacking. Bovine calves are a good model for RSV bronchiolitis. We answered the following two questions: (1) does point-of-care lung ultrasound reflect lung pathology at the histological level in a bovine calf model of bronchiolitis? and (2) are point-of-care lung ultrasound images in human infants similar to those obtained in calves? Methods We experimentally infected 24 five to six-week-old bovine calves with RSV and compared six window lung ultrasound with lung histology10 days after inoculation. The calves were treated with antivirals and antipyretics leading to variable severity of illness. We used canonical discriminant analysis to determine if abnormal lung ultrasound findings reflected different histological findings. We compared the ultrasounds obtained from the calves with ultrasounds obtained from 10 human infants who were diagnosed clinically with bronchiolitis. Results Canonical discriminant analysis generally demonstrated good class separation based on the maximal severity of ultrasound finding in each acoustic window. Lung ultrasound performed poorly at detecting bronchopneumonia. Bovine ultrasounds looked similar to human infant lung ultrasounds. Conclusion Point-of-care lung ultrasound abnormalities reflect lung pathology at the histological level in a bovine calf model of bronchiolitis. Point-of-care lung ultrasound images in human infants are similar to those obtained in calves.

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“…excluded as reviews, [21][22][23][24][25] 2 due to lack of sonographic data, 26,27 and 1 as non-relevant to the topic because it presents diaphragm ultrasound data. 28 Finally, 18 of them [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] were eligible for use in this systematic review. For detailed characteristics of each study see Table 1.…”

Section: Key Notesmentioning

confidence: 99%

Lung ultrasound systematic review shows its prognostic and diagnostic role in acute viral bronchiolitis

et al. 2022

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Acute viral bronchiolitis is a clinical syndrome with varying symptoms. In developed countries, bronchiolitis is the most common reason for hospitalisation in the first 12 months of life. 1,2 Up to 6% of these patients require admission to the paediatric intensive care unit (PICU). 3 It is characterised by inflammation and oedema of the tracheobronchial tree, along with increased mucus production and apoptosis of airway epithelial cells. 4 A diagnosis of bronchiolitis is based on medical history and physical examination. 5 The disease lacks a pathognomonic radiological pattern. 6 Radiographic features suggesting viral bronchiolitis when using chest radiography may include lung hyperinflation, peribronchial wall thickening often symmetrical and bilateral, lack of focal consolidation in the lungs,

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Usefulness of early lung ultrasound in acute mild–moderate acute bronchiolitis. A pilot study

Cited by 9 publications

References 24 publications

Early assessment of lung aeration using an ultrasound score as a biomarker of developing bronchopulmonary dysplasia: a prospective observational study

Early assessment of lung aeration using an ultrasound score as a biomarker of developing bronchopulmonary dysplasia: a prospective observational study

Validating a bovine model for lung ultrasound of bronchiolitis

Lung ultrasound systematic review shows its prognostic and diagnostic role in acute viral bronchiolitis

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