Usefulness of cord-blood harvesting for autologous transfusion in surgical newborns with antenatal diagnosis of congenital anomalies

Imura, Kenji; Kawahara, Hiroyuki; Kitayama, Yasuhiro; Yoneda, Akihiro; Yagi, Makoto; Suehara, N.

doi:10.1053/jpsu.2001.23952

Cited by 33 publications

(35 citation statements)

References 19 publications

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“…However, the safety of such low hematocrit is still not determined [14]. At the same time, numerous studies in neonatology have proven the feasibility, effectiveness, and safety of autologous UCB transfusion in premature neonates and those requiring surgical intervention at or near the time of delivery [4][5][6][7]. UCB conserved by CDPA can be used for as long as 3 weeks after harvesting and even longer if separated into components.…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, we identified a few limitations of our method such as a limited volume of autologous UCB and applicability of this approach only to neonates with prenatally diagnosed congenital malformations. Risk of bacterial contamination is described in the majority of the observational studies [4,7]. Some studies mentioned that the extensive training and experience could significantly lower the contamination rates [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Bloodless cardiopulmonary bypass (CPB) strategies in infants are proposed but they have limited application because of hemodilution, particularly in neonates with weight less than 4 kg [3]. Possibility and effectiveness of autologous umbilical cord blood transfusion in neonates were proved [4][5][6][7]. However, the use of umbilical cord blood (UCB) in neonatal open cardiac surgery has not been studied.…”

Section: Introductionmentioning

confidence: 99%

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Open cardiac surgery in the first hours of life using autologous umbilical cord blood☆

Fedevych¹,

Chasovskyi²,

Vorobiova³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Open cardiac surgery in the first hours of life using autologous umbilical cord blood☆

Fedevych¹,

Chasovskyi²,

Vorobiova³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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“…As expected, total/actual volumes collected are greater with term than preterm neonates. However, when expressed as milliliters per body weight, the expected volume is about 20 mL/kg of whole blood with a hemoglobin concentration varying from 12 to 16 g/dL, depending on gestational age (13, 14, 21, 24, 25). Volumes collected successfully from the placenta vary greatly among individual infants, particularly for the smallest of preterm neonates who are the most challenging.…”

Section: Placental Blood Collection and Storagementioning

confidence: 99%

Is There a Role for Autologous/Placental Red Blood Cell Transfusions in the Anemia of Prematurity?

Strauss

Widness

2010

Transfusion Medicine Reviews

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Because most extremely preterm infants with birth weight <1,000 g need red blood cell transfusions, many attempts have been made to collect, process and store placental blood (i.e., umbilical cord blood) for autologous transfusions. Although it is feasible to do this, multiple problems in doing so including insufficient volumes collected, clotting, hemolysis, bacterial contamination, failure to significantly supplant need for allogeneic transfusions, and high costs have led many to question whether, on balance, autologous/placental RBC transfusion offers clinically significant benefits. Keywords placental blood; umbilical cord blood; neonatal RBC transfusions; neonatal/infant autologous RBC transfusionsThe short answer to the question posed by the title of this paper as to whether there is a role for autologous/placental RBC transfusions in the anemia of prematurity is "Little, at best." The more complete and accurate answer at present is "It depends on several factors and what is desired to be achieved." This paper will critically assess published information pertaining to these "several factors and desired achievements." Need for RBC TransfusionsPreterm infants with birth weight <1,000 g (commonly designated as extremely low birth weight, or ELBW, infants) have completed ≤29 weeks gestation, and nearly all will need RBC transfusions during the first weeks of life. Every week in the United States, approximately 10,000 infants are born prematurely (i.e., <37 weeks gestation) with 600 (6%) of these infants being ELBW (1). Approximately 90% of ELBW neonates will receive at least 1 RBC transfusion (2,3). Physiological and non-physiological factors related to prematurity are responsible for this high transfusion rate, with laboratory blood loss as perhaps the biggest contributor (4). Because of efforts to minimize the amounts of blood drawn from neonates for laboratory testing (5), and to transfuse more conservatively (i.e., to accept lower pretransfusion hematocrit values), the number of RBC transfusions given to preterm infants has dropped over the years (2,6), with the mean value ±SD during years 2000 to 2005 of RBC transfusions given

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“…Obwohl bisherige Studien zeigen, dass in speziellen Indikationen durch den Einsatz von plazentarem Eigenblut bis ca. 40 % der Kinder frei von Fremdblut gehalten werden können [14,16,19], hat sich die Methode bisher trotz einer anfänglichen Euphorie nicht durchgesetzt. Nach eigenen Erfahrungen spielt hierbei weniger die mangelnde Einsatz-und Kooperationsbereitschaft der beteiligten Fachdisziplinen Geburtshilfe, Transfusionsmedizin und Pädiatrie als vielmehr der schon für die normale Eigenblutanwendung komplizierte und bei der Herstellung von autologen plazentaren Erythrozytenkonzentraten noch unübersichtlichere rechtliche Hintergrund eine Rolle.…”

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Juristische Aspekte bei der Herstellung und Verwendung von Plazentablut-Erythrozytenkonzentraten in Deutschland

Brune

Garritsen²,

Louwen³

et al. 2005

Z Geburtshilfe Neonatol

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Usefulness of cord-blood harvesting for autologous transfusion in surgical newborns with antenatal diagnosis of congenital anomalies

Cited by 33 publications

References 19 publications

Open cardiac surgery in the first hours of life using autologous umbilical cord blood☆

Open cardiac surgery in the first hours of life using autologous umbilical cord blood☆

Is There a Role for Autologous/Placental Red Blood Cell Transfusions in the Anemia of Prematurity?

Juristische Aspekte bei der Herstellung und Verwendung von Plazentablut-Erythrozytenkonzentraten in Deutschland

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