Usefulness of contrast‐enhanced ultrasound with <scp>S</scp>onazoid for evaluating liver abscess in comparison with conventional <scp>B</scp>‐mode ultrasound

Kishina, Manabu; Koda, Masahiko; Tokunaga, Shiho; Miyoshi, Kennichi; Fujise, Yuki; Kato, Jun; Matono, Tomomitsu; Sugihara, Takaaki; Murawaki, Yoshikazu

doi:10.1111/hepr.12347

Cited by 31 publications

(31 citation statements)

References 19 publications

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“…Tumorous areas of CRC have been reported to not be enhanced with CEUS (23). The results of previous studies are in accordance with this previously published literature (20)(21)(22)(23). Previous reports and the results from the present WBC, white blood cell count; Hb, hemoglobin; CRP, c-reactive protein; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; Sigmoid, sigmoid colon; Ascending, ascending colon; Well, well-differentiated tubular adenocarcinoma; Mod, moderately differentiated tubular adenocarcinoma; pSS, invasion to subserosa.…”

Section: Discussionsupporting

confidence: 92%

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Unenhanced areas revealed by contrast-enhanced abdominal ultrasonography with Sonazoid™ potentially correspond to colorectal cancer

Tomizawa

Togashi

Shinozaki

et al. 2016

Experimental and Therapeutic Medicine

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Section: Discussionsupporting

confidence: 92%

“…In the liver, non-tumorous areas become diffusely enhanced while liver abscesses and metastases remained unenhanced (20,21). In the present study, CEUS revealed enhancement of non-tumorous areas, while CRC tissue remained unenhanced while using Sonazoid TM .…”

Section: Discussionmentioning

confidence: 99%

Unenhanced areas revealed by contrast-enhanced abdominal ultrasonography with Sonazoid™ potentially correspond to colorectal cancer

Tomizawa

Togashi

Shinozaki

et al. 2016

Experimental and Therapeutic Medicine

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“…In some cases the surrounding edema can generate a hypoenhancing area in the periphery [18]. CEUS is also helpful for delineating avascular areas inside the abscess [19,20] and identifying 4 possible sonomorphologic stages of the disease: stage I -defined by focal inflammation without necrosis; stage II -by focal clusters of micro-abscesses while CEUS allows to establish the area that needs drainage and to find the best position for the tip of the drainage. Whenever possible, a transhepatic access route is preferred for direct puncture to avoid pus leakage into the peritoneal cavity.…”

Section: Discussionmentioning

confidence: 99%

Does Contrast Enhanced Ultrasound improve the management of liver abscesses? A single centre experience

Spârchez

Radu²,

Kacsó

et al. 2015

Med Ultrason

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Liver abscess is a potentially lethal condition that requires prompt recognition and adequate treatment for a good outcome. The aim of this study was to assess the value of contrast enhanced ultrasound (CEUS) in the management of liver abscesses in the clinical practice of a single centre. Material and methods: A retrospective analysis was performed including all patients diagnosed with liver abscesses during 5 years (2010-2014) in a tertiary Department of Gastroenterology and Hepatology. The demographic data, the presence of risk factors, the cause of liver abscess, the B-mode conventional US aspect, the CEUS appearance and the patient's outcome were documented and analyzed. Results: The study group included 41 patients diagnosed with liver abscesses (17 women and 24 men, mean age 63.3±13.2 years), 16/41 (39%) of them with diabetes mellitus. A single lesion was found in 28 (68.3%) patients, and 13 (31.7%) patients had multiple abscesses. The CEUS study was conclusive for the diagnosis of liver abscess in clinical context in 38/41 cases (92.7%). All conclusive cases presented rim enhancement in the arterial phase and no enhancement in the liquid areas. The honeycomb appearance with septa enhancement was present in 17/41 (41.5%) patients. Washout of the marginal rim was found in 22/41 (53.6%) lesions. Conclusion: In our group the most frequent CEUS features found were the rim enhancement in the arterial phase and the presence of no enhancement areas, followed by the honeycomb appearance. CEUS was able to be conclusive for the diagnosis of liver abscess in almost 93% of cases.

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“…The initial inflammatory process is often isoechoic in comparison with the surrounding organ parenchyma and occasionally difficult to recognize. The appearance of any abscess is likely to alter over time as the contents of the abscess develop (19). Almost all abscesses demonstrate irregular rim enhancement with central nonenhanced areas at CEUS (12).…”

Section: Drainage and Ceus Tubographymentioning

confidence: 99%

Contrast-enhanced US–guided Interventions: Improving Success Rate and Avoiding Complications Using US Contrast Agents

Huang¹,

Yusuf²,

Daneshi³

et al. 2017

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Ultrasonography (US) is an established modality for intervention. The introduction of microbubble US contrast agents (UCAs) has the potential to further improve US imaging for intervention. According to licensing, UCAs are currently approved for clinical use in restricted situations, but many additional indications have become accepted as having clinical value. The use of UCAs has been shown to be safe, and there is no risk of renal toxic effects, unlike with iodinated or gadolinium contrast medium. Broadly speaking, UCAs can be injected into the bloodstream (intravascular use) or instilled into almost any accessible body cavity (endocavitary use), either in isolation or synchronously. In microvascular applications, contrast-enhanced US (CEUS) enhances delineation of necrotic areas and the vascularized target to improve real-time targeting. The ability of CEUS to allow true assessment of vascularity has also been used in follow-up of devascularizing intervention. In macrovascular applications, real-time angiographic images can be obtained with CEUS without nephrotoxic effects or radiation. In endocavitary applications, CEUS can achieve imaging similar to that of iodinated contrast medium-based fluoroscopy; follow-up to intervention (eg, tubography and nephrostography) can be performed at the bedside, which may be advantageous. The use of UCAs is a natural progression in US-guided intervention. The aim of this article is to describe the indications, contraindications, and techniques of using UCAs as an adjunctive tool for US-guided interventional procedures to facilitate effective treatment, improve complication management, and increase the overall success of interventional procedures. Online supplemental material is available for this article. RSNA, 2016.

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Usefulness of contrast‐enhanced ultrasound with Sonazoid for evaluating liver abscess in comparison with conventional B‐mode ultrasound

Cited by 31 publications

References 19 publications

Unenhanced areas revealed by contrast-enhanced abdominal ultrasonography with Sonazoid™ potentially correspond to colorectal cancer

Unenhanced areas revealed by contrast-enhanced abdominal ultrasonography with Sonazoid™ potentially correspond to colorectal cancer

Does Contrast Enhanced Ultrasound improve the management of liver abscesses? A single centre experience

Contrast-enhanced US–guided Interventions: Improving Success Rate and Avoiding Complications Using US Contrast Agents

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