Usefulness of Contrast-Enhanced Intraoperative Ultrasound Using Sonazoid in Patients With Hepatocellular Carcinoma

Arita, Junichi; Takahashi, M.; Hata, Shojiro; Shindoh, Junichi; Beck, Yoshifumi; Sugawara, Yasuhiko; Hasegawa, Kiyoshi; Kokudo, Norihiro

doi:10.1097/sla.0b013e31822518be

Cited by 66 publications

(54 citation statements)

References 48 publications

(61 reference statements)

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“…The most used second-generation contrast medium is SonoVue (gaseous sulphur hexafluoride; Bracco, Milano Italy), which nowadays has a recognized diagnostic role for liver disease [22]. Recently, in Japan a new second-generation contrast medium has been used, Sonazoid (gaseous perflubutane; GE Healthcare, Norway), that has the advantage of Kupffer imaging in addition to vascular imaging, thus theoretically providing greater diagnostic accuracy [23]. …”

Section: Staging Of Hccmentioning

confidence: 99%

Intraoperative Ultrasound in Patients with Hepatocellular Carcinoma: From Daily Practice to Future Trends

Donadon

Torzilli²

2013

Liver Cancer

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Starting from the end of the 1970s, intraoperative ultrasound was introduced and developed to stage liver disease and guide the surgical interventions in patients with hepatocellular carcinoma. Without intraoperative ultrasound, it would probably be impossible to correctly define the hepatic segments as well as the limits of a tumor, also because of the existing wide variations in the anatomy. More importantly, intraoperative ultrasound allows for three-dimensional reconstruction of the relationships between the tumor, hepatic veins, and Glissonian pedicles. Such reconstruction is essential for planning the surgical strategy, which should be individualized in each patient with the aim to spare functional liver parenchyma. This work focuses on the role of intraoperative ultrasound to stage liver disease and to plan surgical resection, describing the most recent technical achievements.

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Section: Staging Of Hccmentioning

confidence: 99%

Intraoperative Ultrasound in Patients with Hepatocellular Carcinoma: From Daily Practice to Future Trends

Donadon

Torzilli²

2013

Liver Cancer

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“…The conventional intraoperative ultrasonography and the enhanced ultrasonography using some contrast medium are also helpful for us to understand the anatomic relationship between the important vessels (such as IRHV) to be preserved and tumor border intraoperatively [19,20]. The significance of the IRHV preserving liver resection is now increased by the remarkable advance in the surgery-related techniques and devices.…”

Section: Discussionmentioning

confidence: 99%

Reappraisal of the Inferior Right Hepatic Vein Preserving Liver Resection

Takahashi

Hasegawa²,

Aoki³

et al. 2014

Dig Surg

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Background: To resect tumors infiltrating to the right hepatic vein at its root, right hemihepatectomy or that following portal vein embolization (PVE) is applied. If the IRHV is sizable, the IRHV preserving liver resection can be another option. Methods: Between 1994 and 2007, the IRHV preserving liver resection was performed in 21 patients (IRHV group). The short-term outcomes after surgery of them p. Results: There were no mortality and no significant difference between the IRHV and RH groups concerning the blood loss, the morbidity rates and the duration of hospital stay. The median operation time was shorter in the IRHV group than in the RH group (393 vs. 480 min, p = 0.0409). The median weight of resected specimen of the IRHV group was 293 g (range: 20-982), which was significantly lighter than that of the RH group (median: 680 g [250-4,300], p < 0.001). The median percentage of resected volume to standard liver volume was significantly smaller in the IRHV group than in the RH group (25.8 vs. 52.2%, p < 0.001). Conclusion: The IRHV preserving liver resection remains a safe and useful procedure.

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“…In addition to this ability, CE-IOUS using Sonazoid enables the detection of new HCC tumors that are unidentifiable either by preoperative imaging modality or by IOUS [11]. Recently, the authors reported CE-IOUS to be useful in clearly visualizing the border of tumors during laparoscopic hepatectomy for which energy devices are frequently used [33].…”

Section: Contrast-enhanced Iousmentioning

confidence: 99%

“…Diagnostic accuracy of CE-IOUS to differentiate HCC among nodules that are intraoperatively identified by IOUS is reported to be approximately 80% [10,11] (table 1). In addition to this ability, CE-IOUS using Sonazoid enables the detection of new HCC tumors that are unidentifiable either by preoperative imaging modality or by IOUS [11].…”

Section: Contrast-enhanced Iousmentioning

confidence: 99%

“…First, 3-dimensional (3D) CT enabled virtual planning for the real surgery by presenting the image of the tumor and liver and by providing an accurate estimation of the regional liver volume [5,6,7,8]. Second, contrast-enhanced IOUS (CE-IOUS) with the new ultrasound contrast agent Sonazoid (gaseous perflubutane; GE Healthcare, Oslo, Norway) [9] was developed and applied to liver resection, allowing for more accurate intraoperative staging of hepatocellular carcinoma (HCC) [10,11] and a higher rate of detection of colorectal liver metastasis [12]. Finally, fluorescence imaging using indocyanine green (ICG) was applied to hepatobiliary surgery for intraoperative visualization of bile [13,14,15,16], liver cancers [17,18,19] and hepatic segments to be resected [20,21,22] as well as for evaluation of regional portal uptake in the liver [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Advances in Assessment and Planning for Surgical Treatment of Hepatocellular Carcinoma

Kawaguchi

Hasegawa²,

Tanaka³

et al. 2015

Dig Dis

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This chapter covers recent important topics relevant to ensuring safe liver resection. In particular, preoperative and intraoperative techniques, such as 3-dimensional CT, intraoperative ultrasonography with contrast agent and fluorescence imaging using indocyanine green are reportedly useful and have been applied to liver resection and liver transplantation. We, herein, describe the performance of liver resection under the guidance of these techniques and present tips for more accurate intraoperative tumor detection and safer surgical procedures.

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Usefulness of Contrast-Enhanced Intraoperative Ultrasound Using Sonazoid in Patients With Hepatocellular Carcinoma

Abstract: With help of CE-IOUS using Sonazoid, more accurate intraoperative staging for HCC can be performed.

Cited by 66 publications

References 48 publications

Intraoperative Ultrasound in Patients with Hepatocellular Carcinoma: From Daily Practice to Future Trends

Intraoperative Ultrasound in Patients with Hepatocellular Carcinoma: From Daily Practice to Future Trends

Reappraisal of the Inferior Right Hepatic Vein Preserving Liver Resection

Advances in Assessment and Planning for Surgical Treatment of Hepatocellular Carcinoma

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