Usefulness of contrast-enhanced CT in the evaluation of depth of invasion in oral tongue squamous cell carcinoma: comparison with MRI

Baba, Akira; Ojiri, Hiroya; Ogane, Satoru; Hashimoto, Kazuhiko; Inoue, Takashi; Takagiwa, Mutsumi; Goto, Tazuko K.

doi:10.1007/s11282-020-00429-y

Cited by 29 publications

(20 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the UICC and AJCC state that ultrasonography is not suitable for the evaluation of primary lesions [9], some studies have evaluated primary lesions with intraoral ultrasonography (US) and have shown a strong correlation with histopathological thickness or DOI [10][11][12][13]. To date, several reports have been made on CT, MRI, and US preoperative radiological DOI evaluations, but there is no report of a study where these were all performed in a single institution [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Therefore, this study was aimed to investigate the accuracy of preoperative radiological DOI measurement with CT, MRI, and US in the same target group based on histopathologically measured DOI for T1 and T2 tongue cancers, where a diagnosis of DOI around 5 mm is an important diagnostic finding and examine the effectiveness of each imaging modalities with retrospective approach.…”

Section: Introductionmentioning

confidence: 99%

A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

Objectives This study aimed to clarify the accuracy of intraoral ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) in preoperative image depth of invasion (DOI) measurement of T1/T2 tongue cancer through comparison with histopathological measurements. Methods Imaging of the primary lesions was performed at our hospital; the lesions were classified into T1 and T2 based on the 8th edition of the AJCC/UICC, and surgery performed. There was histopathological confirmation of lesions as squamous cell carcinoma in 48 patients with tongue cancer. T3 and T4 cases, cases in which preoperative chemotherapy and radiation therapy were performed, and cases where biopsy was performed before imaging were excluded. The radiological DOI in US, CT, and MRI and the histopathological DOI as base were comparatively investigated and statistical analyses were performed by Bland–Altman analysis and Spearman's rank correlation coefficient. Results Bland–Altman analysis showed that the US radiological DOI was overestimated by an average of 0.2 mm compared to the histopathological DOI, while CT and MRI radiological DOI were overestimated by an average of 2–3 mm. The comparison of CT and MRI revealed that the difference between the MRI and histopathological DOI, as well as the 95% limit of agreement, were smaller than those of the CT radiological DOI. Conclusions US is the most accurate preoperative diagnostic tool for T1 and T2 squamous cell carcinoma; CT and MRI tend to have an overestimation of about 2–3 mm and so caution is required.

show abstract

Section: Introductionmentioning

confidence: 99%

A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Previous studies have reported similar correlation coefficients for CT and MRI. In a recently published study, CT performed better than MRI (r = 0.74 for CT vs. r = 0.69 and 0.66 for T1-and T2-weighted MRI, respectively) [15]. Another study from the Netherlands show somewhat better correlation coefficient for MRI (r = 0.72), although they only reported data for T1-weighted images [21].…”

Section: Discussionmentioning

confidence: 96%

“…While some have reported better accuracy of CT over MRI [15], the measurements variations specific to each modality have been only scarcely reported [10,16]. Similarly, the measurements variations specific to each DOI and how they may change between thin and thick tumors have not been thoroughly reported [10,16].…”

Section: Introductionmentioning

confidence: 99%

Measurement variations of MRI and CT in the assessment of tumor depth of invasion in oral cancer: A retrospective study

Waech

Pazahr

Guarda

et al. 2021

European Journal of Radiology

View full text Add to dashboard Cite

In oral squamous cell carcinoma (OSCC), depth of invasion (DOI) is an important predictive, prognostic, and staging parameter. While it is known that DOI can be estimated from preoperative imaging, an analysis of measurements variations according to imaging modality and to depth of tumor itself is lacking. The aim of the study was to assess the accuracy of imaging-based estimation of DOI in relation with the tumor histological DOI. Methods: We retrospectively reviewed 121 patients with OSCC treated at University Hospital Zurich. The radiologic DOI of CT, T1-weighted, and T2-weighted MRI were compared with histological DOI. Frequency of relevant imaging artifacts was assessed as well. Results: A total of 110 CT (90.9 %) and 90 MRI (74 %) were analyzed. Both modalities were available for 79 patients (65.3 %). The median histological depth of invasion was 9 mm (IQR 4.5-14). The median depth of invasion was 14 mm (IQR 10-20) on CT, 13 mm (IQR 8.25-18) on T1-weighted MRI, and 13 mm (IQR 9-18.75) on T2-weighted MRI. All diagnostic modalities tended towards an overestimation of the histopathologic DOI from about 5-15 %. This trend was most pronounced for thin tumors, for which both CT and MRI lead to upstaging in over 50 % of the cases. For 25 (22.7 %) patients, dental scattering on CT rendered DOI not estimable. For MRI, 18 patients (20 %) had artifacts (blooming, motion artifacts) rendering DOI not estimable. Conclusion:CT and MRI measurements of DOI in OSCC lead to an overestimation of histological DOI, especially in tumors with DOI<5 mm, with upstaging by imaging in over 50 % of the cases. Artifacts were present in more than 20 % of performed images.

show abstract

“…There are many comparative studies between r-DOI and p-DOI using ultrasound [8,19] or MRI [3,7,20,21]. Several studies stated that CT [22,23] is also useful for evaluation of r-DOI; however, CT cannot evaluate r-DOI when the contrast is low, super cial lesions cannot be detected, and metal artifacts often disturb images of tumor location. Therefore, we used ultrasound and MRI.…”

Section: Discussionmentioning

confidence: 99%

MRI Before Biopsy Correlates With Depth of Invasion Corrected for Shrinkage Rate of the Histopathological Specimen in Tongue Carcinoma

Harada

Tomioka

Hirai

et al. 2021

Preprint

View full text Add to dashboard Cite

The purpose of this study was to evaluate which radiological depth of invasion (r-DOI) measurement is the most concordant to clinical DOI (c-DOI) derived from correction for the shrinkage rate of the histopathological specimens.We retrospectively reviewed 128 patients with tongue carcinoma who had undergone glossectomy between 2006 and 2019. At first, the width shrinkage rate during formalin fixation and preparation process of histopathological specimens was evaluated. From the shrinking rates, a formula to calculate c-DOI from pathological DOI (p-DOI) was developed. The correlation between c-DOI and r-DOI was evaluated.The specimen shrinkage rate during the histopathological specimen preparation process was 10.3%. Based on that, we yielded the correct formula for c-DOI based on p-DOI and preparation shrinkage rate: c-DOI = p-DOI × 100/89.7. The regression equations for the association of c-DOI with r-DOI measured by ultrasound (n = 128), MRI before biopsy (n = 18), and MRI after biopsy (n = 110) were y = 1.12 * x + 0.21, y = 0.89 * x − 0.26, and y = 0.52 * x + 2.63, respectively, while the coefficients of determination were 0.664, 0.891, and 0.422, respectively. In conclusion, r-DOI using MRI before biopsy most strongly correlated with c-DOI.

show abstract

Usefulness of contrast-enhanced CT in the evaluation of depth of invasion in oral tongue squamous cell carcinoma: comparison with MRI

Cited by 29 publications

References 28 publications

A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma

A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma

Measurement variations of MRI and CT in the assessment of tumor depth of invasion in oral cancer: A retrospective study

MRI Before Biopsy Correlates With Depth of Invasion Corrected for Shrinkage Rate of the Histopathological Specimen in Tongue Carcinoma

Contact Info

Product

Resources

About