Usefulness of certain varieties of Carbomer in the formulation of hydrophilic furosemide matrices

Pérez-Marcos, B.; Gutiérrez, Covadonga; Gómez-Amoza, J.L.; Martínez‐Pacheco, Ramón; Souto, C.; Concheiro, Angel

doi:10.1016/0378-5173(91)90423-l

Cited by 35 publications

(14 citation statements)

References 11 publications

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“…This could be due to the effect of the pH sensitivity of ADM and Cp to gelation and swelling. Due to the higher rate of swelling and gelation of ADM and Cp at high pH (7,15) the degree of stress relaxation within the tablet matrix is also increased thus the hydrated polymer is more rubbery thus making the surface stress induced by rotation of the basket more effective in the SIF than in SGF hence the higher rate of attrition in SIF. At equal polymer concentrations (Table 1), the rate of attrition of matrix tablets prepared with ADM was less than that for HPMC in SGF and in both SGF and SIF in Cp (Figs.…”

Section: Attrition Profilementioning

confidence: 99%

Evaluation of the controlled release potential of

Builders¹,

Okeke²,

Egieye³

2008

J. Phyto. Therap.

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The suitability of A. digitata mucilage (ADM) as an excipient in the formulation of matrix tablets, the mechanism and kinetics of drug delivery were studied. Aminophyline was the prototype drug while these properties were compared to those of HPMC and Cp. ADM was used at concentration levels of 10, 15 and 30% of the tablet weight while HPMC and Cp were used at 30% concentration. The tablet friability, attrition and dissolution characteristics were evaluated. All the tablets formulated showed good physical properties. The ADM matrix tablets showed similar drug release and attrition pattern to those of Cp in both SIF and SGF. Generally the drug release retardation efficiency of the ADM tablets at equal polymer concentration was higher than those of Cp but less than that of HPMC in both SGF and SIF. The mechanism of release of aminophyline from ADM as in Cp and HPMC was by diffusion.

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Section: Attrition Profilementioning

confidence: 99%

Evaluation of the controlled release potential of

Builders¹,

Okeke²,

Egieye³

2008

J. Phyto. Therap.

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“…Perez-Marcos et al [30,31] compared the release mechanisms of carbopol matrix for drugs with different solubility. Highly water soluble drug, atenolol, exhibited square-root-of-time dependent drug release while poorly water soluble drug, furosemide, exhibited zero order release.…”

Section: Effect Of Drug Solubility On Drug Release From Carbopol Matrixmentioning

confidence: 99%

“…Excipients used in the formulations containing carbopol as release controlling matrix can have significant impact on controlled release property of the matrix [23,30,94]. Carbopol is compatible with most of the commonly used excipients such as anhydrous lactose, hydrated lactose, dicalcium phosphate, talc, magnesium stearate and starch.…”

Section: Excipients In Controlled Release Formulationsmentioning

confidence: 99%

“…When fully hydrated, the osmotic pressure will break up the structure and shed off individual pieces of hydrogels. This unique property contributes carbopol's ability to release drug in near zero order fashion for long time [23][24][25][26][27][28][29][30][31]. It is hypothesized that upon gelling the surface of the polymer particles has gel layer.…”

Section: Molecular Weight Of Carbopolmentioning

confidence: 99%

“…Perez Marcos [30] formulations [64,66,85,86]. In general, carbopol is blended with other controlled release polymer to optimize the drug release profiles.…”

Section: Bioadhesion Characteristics and Drug Releasementioning

confidence: 99%

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Novel Carbopol-Wax Blends for Controlled Release Oral Dosage Forms

Mariageraldrajan¹

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Carbopol is crosslinked acrylic acid. Carbopol can be used in developing formulations for transdermal, oral, rectal use. It is forms strong gel in low concentration. Therefore, it can be used in low concentration in developing controlled release formulations. This increases the cost effectiveness and number of formulation options. In spite of its effectiveness, carbopol is one of the most efficient however underutilized polymer in oral controlled drug delivery system development. This is attributed to the difficulty in processing the carbopol. Carbopol has poor flow characteristics and stickiness. Objective of our research is to eliminate processing difficulties of carbopol using hot melt granulation process and to develop sustained release oral formulations of a basic (Propranolol HCl) and an acidic drug (Glipizide).Hot melt granulation was used to prepare free-flowing, directly compressible carbopolwax blends. Evaluation of granular characteristics of carbopol-wax blends indicated that changes in the granular characteristics is dependent on process variables such as granulation temperature, granulation time and mixing speed. At higher granulation temperature, the granulation process became sensitive to granulation time and mixing speed. Thus, for developing robust granulation process to prepare carbopol-wax blends, the granulation must be done with lower granulation temperatures.Carbopol is an acidic polymer and forms complex with basic drugs. Carbopol-basic drug complex has poor solubility. Hence oral controlled delivery system containing carbopol and basic drug, result in incomplete drug release. Water uptake and tablet erosion studies confirmed that incomplete drug release is a result of ionic complexation and absence of tablet erosion.Thus, by selecting appropriate carbopol grade, extent of ionic complexation was reduced and by iv using soluble filler in the formulation, an USP compliant controlled release oral formulation of propranolol hydrochloride was developed.Controlled release properties of carbopol matrix containing Glipizide were evaluated.Formulations containing lactose as filler, either had long lag time or burst release based on the concentration of lactose in the formulation. Formulations containing Avicel yielded tablets with high hardness and zero order drug release. The drug release pattern of Avicel based formulations was dependent on drug-polymer ratio. Release of Glipizide from Avicel based formulations was dependent on compression force. Bioequivalent formulation of Glipzide was prepared using carbopol-wax blend.Near infrared spectrophotometer was used to predict dissolution profiles of propranolol sustained release tablets non-destructively. Three different modeling algorithms were compared for their predictability. K-nearest neighbors algorithm (KNN) yielded models with better predictability compared to partial least squares algorithm and support vector machines algorithm.Model validation was performed using independent data set. Model validation confirmed that KNN models can ...

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