Usefulness of cardiac magnetic resonance imaging in left ventricular non-compaction cardiomyopathy

Martı́n, Marı́a; Barriales, Vicente; Corros, Cecília; Santamarta, Elena

doi:10.1093/eurjhf/hfr028

Cited by 19 publications

(8 citation statements)

References 2 publications

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“…Therefore, absolute quantification should be performed. Cardiovascular magnetic resonance (CMR) has been reported as a promising imaging modality to characterise patients with LVNC as it provides both a high spatial resolution and a good contrast between trabeculation and blood pool [10, 11]. Jacquier et al recently reported that a value of non-compacted LV myocardial mass above 20 % of the global mass of the LV is highly sensitive and specific for LVNC [12].…”

Section: Introductionmentioning

confidence: 99%

Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies

et al. 2012

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ObjectivesTo analyse the value of cardiovascular magnetic resonance (CMR)-derived myocardial parameters to differentiate left ventricular non-compaction cardiomyopathy (LVNC) from other cardiomyopathies and controls.MethodsWe retrospectively analysed 12 patients with LVNC, 11 with dilated and 10 with hypertrophic cardiomyopathy and compared them to 24 controls. LVNC patients had to fulfil standard echocardiographic criteria as well as additional clinical and imaging criteria. Cine steady-state free precession and late gadolinium enhancement (LGE) imaging was performed. The total LV myocardial mass index (LV-MMI), compacted (LV-MMIcompacted), non-compacted (LV-MMInon-compacted), percentage LV-MMnon-compacted, ventricular volumes and function were calculated. Data were compared using analysis of variance and Dunnett’s test. Additionally, semi-quantitative segmental analyses of the occurrence of increased trabeculation were performed.ResultsTotal LV-MMInon-compacted and percentage LV-MMnon-compacted were discriminators between patients with LVCN, healthy controls and those with other cardiomyopathies with cut-offs of 15 g/m2 and 25 %, respectively. Furthermore, trabeculation in basal segments and a ratio of non-compacted/compacted myocardium of ≥3:1 were criteria for LVNC. A combination of these criteria provided sensitivities and specificities of up to 100 %. None of the LVNC patients demonstrated LGE.ConclusionsAbsolute CMR quantification of the LV-MMInon-compacted or the percentage LV-MMnon-compacted and increased trabeculation in basal segments allows one to reliably diagnose LVNC and to differentiate it from other cardiomyopathies.Key Points• Cardiac magnetic resonance imaging can reliably diagnose left ventricular non-compaction cardiomyopathy.• Differentiation of LVNC from other cardiomyopathies and normal hearts is possible.• The best diagnostic performance can be achieved if combined MRI criteria for the diagnosis are used.

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Section: Introductionmentioning

confidence: 99%

Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies

et al. 2012

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“…Thus, imaging modalities, e.g. standard echocardiography and cardiac magnetic resonance (CMR), play a fundamental role in the diagnosis of LVNC 2–4,15–18. As awareness of this disease entity gradually increased, it has been found that prominent trabeculations are present not only in LVNC but also in some individuals with dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), hypertensive heart disease, or even in a small number of healthy persons 8,19.…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic quantification of regional deformation helps to distinguish isolated left ventricular non‐compaction from dilated cardiomyopathy

Niemann

Liú

et al. 2012

European J of Heart Fail

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AimsPronounced trabeculation is presented in both left ventricular non-compaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation difficult. We hypothesized that echocardiographic deformation analysis would help to differentiate these two cardiomyopathies. Methods and resultsWe investigated 15 patients with LVNC (9 males; 42 + 9 years), 15 age-and gender-matched DCM patients, and 15 healthy controls. The echocardiographic diagnosis of LVNC was confirmed by magnetic resonance imaging. In all subjects standard echocardiography and tissue Doppler imaging (TDI) to study regional LV deformation were carried out. No statistical difference was observed in standard echocardiographic parameters between LVNC and DCM patients. Compared with controls, both patient groups showed significantly reduced annular displacements (septal: controls 14 + 2 mm vs. DCM 6 + 3 mm vs. LVNC 7 + 3 mm) and reduced strain values of the LV segments. A characteristic deformation pattern with significantly higher values in the LV base compared with the apex was observed in patients with LVNC by deformation measurements with TDI. This gradient was found particularly in the lateral and inferior wall but spared the anteroseptal wall; non-compaction was not found in basal segments throughout the ventricle and also spared the anteroseptal midventricular wall. In DCM the strain and strain rate values were homogeneously reduced in all LV segments. ConclusionA special regional deformation pattern (preserved deformation in basal segments of LVNC) seems to be of major diagnostic help for the definite differential diagnosis of LVNC and DCM.--

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“…Pode apresentar-se com manifestações de IC por disfunção sistólica e/ou diastólica, ou com arritmias cardíacas ou ainda com fenômenos tromboembólicos. O ecocardiograma e a ressonância magnética do coração são os exames complementares de escolha no diagnóstico 285,286 . Não existem estudos específicos no tratamento da IC nesse grupo de pacientes.…”

Section: Miocárdio Não Compactado (Tabela 36)unclassified

Atualização da Diretriz Brasileira de Insuficiência Cardíaca Crônica - 2012

2012

Arquivos Brasileiros De Cardiologia

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Usefulness of cardiac magnetic resonance imaging in left ventricular non-compaction cardiomyopathy

Cited by 19 publications

References 2 publications

Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies

Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies

Echocardiographic quantification of regional deformation helps to distinguish isolated left ventricular non‐compaction from dilated cardiomyopathy

Atualização da Diretriz Brasileira de Insuficiência Cardíaca Crônica - 2012

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