Usefulness of Carcinoembryonic Antigen Measurement in Gastric Juice of Patients with Gastric Disorders

Micali, B; Gioffré-Florio, Maria; Venuti, Assunta; Artemisia, A.; Caputo, Gregory M.; Brancato, U

doi:10.1097/00004836-198310000-00007

Cited by 9 publications

(3 citation statements)

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“…As in the search for serum biomarkers, several groups have investigated the diagnostic utility of known tumor markers in gastric juice. Neither CEA nor CA 19-9 positivity in gastric fluid has demonstrated diagnostic accuracy [43][44][45][46]. Alpha-1 antitrypsin in gastric juice has recently been reported as a gastric cancer biomarker [47,48].…”

Section: Discussionmentioning

confidence: 99%

The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile

Kon

Yip²,

et al. 2008

BMC Med Genomics

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Section: Discussionmentioning

confidence: 99%

The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile

Kon

Yip²,

et al. 2008

BMC Med Genomics

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“…These changes were supported by immunohistochemical findings which revealed increased expression of CEA and CK-7 suggestive of liver damage. CEA is a non specific marker for cancers and liver inflammation caused by hepatitis or chemotherapy [27] it is also useful in the evaluation of cancer [27], and gastric inflammatory changes which suggest a close relationship between gastric CEA values and the degree of gastric inflammation [28]. The study of cytokeratin expression has provided a valuable insight into the biliary microanatomy of the liver in health and disease.…”

Section: Discussionmentioning

confidence: 99%

Immunohistopathological Effects of Combined Administration of Douvir–N and Folc Acid on the Liver and Some Biochemical Parameters in Albino Wistar Rats

Peter

Ekandem²

2015

AJBIO

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Douvir-N is a combination of lamivudine, zidovudine and nevirapine used for the treatment of patients with Human Immunodeficiency Virus. The objective of this study was to investigate the effect of combined administration of Douvir-N and folic acid on the histology and some Biochemical parameters in the liver of Wistar rats. Forty adult albino Wistar rats were randomly divided into four groups of ten animals each. Group A served as control and were administered with 1ml of distilled water, group B animals were administered with 9.29mg/kg body weight of Douvir-N, Group C animals were administered with a combination of 9.29mg/kg of Douvir-N and 0.07mg/kg of folic acid. Animals in group D were administered with 0.07mg/kg of folic acid. Animals were sacrificed after 30 days and dissected. The liver was removed and fixed in 10% buffered formaldehyde, processed and stained using Haematoxylin and Eosin staining method, carcino-embryonic antigen (CEA) and cytokeratin-7 (CK-7) immunochemistry methods. Stained slides were viewed using light microscope. Blood samples from each rat was collected using syringes and needles, The sera were extracted into fresh test tubes and stored in a refrigerator for analysis of aspartate aminotransaminase test (AST), alanine aminotransaminase test (ALT), alkaline phosphotase (ALP). The liver of Wistar rats administered with Douvir-N showed distortions in the liver with moderate dilatation of the sinusoidal spaces and nuclei pyknotic changes, with increased expression of CEA and CK7 in the groups treated with Douvir-N than the control groups. There was a significant increase in ALP in the Douvir-N groups. These changes were ameliorated when Douvir-N was combined with Folic acid. The findings suggest that Douvir-N can distort the cytoarchitecture and Biochemical parameters of the liver which could be ameliorated by co-administration with folic acid. Folic acid should be given as adjuvant drug to patients on Douvir-N therapy.

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“…Karbonhidrat antijen 19-9 (CA 19-9) ve karsinoembriyonik antijen (CEA), başlıca gastrointestinal sistem (GİS) olmak üzere, birçok epitelyal kökenli malignitelerle ilişkili antijenlerdir [7,8]. Artmış CEA ve CA 19-9 seviyelerinin prekanseröz lezyon ve kanser ile bağlantılı olduğu bildirilmiştir [9]. Diğer taraftan karbonhidrat antijen 72-4 (CA 72-4) gastrointestinal kanserler için daha yüksek spesifitesi olan bir markırdır [10].…”

Section: Introductionunclassified

Comparison of CYFRA 21-1, CEA, CA 19-9 and CA 72-4 levels in gastric cancer

Çakırca¹

2013

Diclemedj

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Objective: Gastric cancer is the fourth most common malignancy,and the second most common cause of cancermortality worldwide. The aim of this study was to investigatethe role of biomarkers CYFRA 21-1, CA 19-9, CEA,CA72.4 at diagnosis and throughout the follow-up in patientswith gastric cancer.Methods: 30 patients with gastric cancer diagnosed and31 healthy people as a control group were included in thisstudy. According to the TNM staging system, there were16 patients with stage II and 14 patients with stage III inthe group of patients with gastric cancer. CEA, CA 19-9,CA 72-4 and CYFRA 21-1 levels were studied by elektrochemiluminescenceimmunasay (ECLIA) method in theCobas e 601 instrument.Results: Statistically the level of CA 72-4, CA 19-9, CEAand CYFRA 21-1 gastric cancer groups was found significanthigh accaording to healthy control group (p<0.01).Statistically compared with II stage patient group, the levelof CA 19-9, CEA and CYFRA 21-1 of III stage patientgroup was found significant high (p<0.01). The diagnosticcut-off, sensitivity and specificity for CEA were 4.15 ng/mL, 46 % and 96%, respectively; for CA 19-9 were 24.50U/mL, 17 % and 96 %; for CA 72-4 were 2.46 U/mL, 53% and 96% and for CYFRA 21-1 were 3.36 ng/mL, 46%and 100%.Conclusion: Our study demonstrates that the associationof biomarkers CYFRA 21-1, CEA, and CA72.4 providesa valuable contribution in the follow-up of gastriccancer patients.Key words: Gastric cancer, tumor markers, CYFRA 21-

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Usefulness of Carcinoembryonic Antigen Measurement in Gastric Juice of Patients with Gastric Disorders

Cited by 9 publications

References 0 publications

The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile

The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile

Immunohistopathological Effects of Combined Administration of Douvir–N and Folc Acid on the Liver and Some Biochemical Parameters in Albino Wistar Rats

Comparison of CYFRA 21-1, CEA, CA 19-9 and CA 72-4 levels in gastric cancer

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