Usefulness of bronchial lavage for the diagnosis of pulmonary disease caused by Mycobacterium avium-intracellulare complex (MAC) infection

Sugihara, Eiichiro; Hirota, Naotoshi; Niizeki, Takashi; Tanaka, Ryo; Nagafuchi, Masako; Koyanagi, Takeshi; Ono, Noriyuki; Rikimaru, Toru; Aizawa, Hisamichi

doi:10.1007/s10156-003-0267-1

Cited by 57 publications

(28 citation statements)

References 11 publications

(13 reference statements)

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“…With regard to pathological findings, our study revealed granuloma in only 11 of 38 patients with MAC lung disease (28.9%). Previous studies showed that granuloma was present in 40.0%–87.5% of patients whose bronchial washing culture was positive for MAC . Notably, an interesting report by Sato et al .…”

Section: Discussionmentioning

confidence: 95%

Limited value of transbronchial lung biopsy for diagnosing Mycobacterium avium complex lung disease

Sekine

Saito

Satoh

et al. 2016

Clinical Respiratory J

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Section: Discussionmentioning

confidence: 95%

Limited value of transbronchial lung biopsy for diagnosing Mycobacterium avium complex lung disease

Sekine

Saito

Satoh

et al. 2016

Clinical Respiratory J

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“…In several studies, the usefulness of bronchoscopy in detecting NTM or tuberculosis in respiratory specimens was shown to be superior to that of sputum culture [8,9,[17][18][19]. In one study, patients with NTM isolates were classified into an NTM lung disease group and a contamination group.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with more than one positive sputum culture for NTM exhibit a typical clinical course of pulmonary disease in contrast to patients with only one positive sputum culture [6]. Furthermore, the diagnostic yield of sputum culture compared to that of bronchoscopic specimens for NTM-PD has been investigated in several studies [7][8][9][10]. However, no study has yet proven whether patients with NTM isolated from bronchoscopic specimens or lung tissue demonstrate disease progression equivalent to that in patients diagnosed using sputum culture.…”

Section: Introductionmentioning

confidence: 99%

Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis

Sin

Han

Lee

et al. 2020

Preprint

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Background Current microbiologic criteria for nontuberculous pulmonary disease (NTM-PD) require cultures with two separate sputum specimens or one non-sputum specimen. However, data on NTM-PD prognosis following non-sputum culture-based diagnosis are limited. We compared the prognosis of NTM-PD diagnosed using non-sputum and sputum cultures. Methods We analyzed 1020 patients in whom NTM was isolated; they were divided into the sputum NTM isolation (n=170), sputum NTM-PD (n=688), and non-sputum NTM-PD groups (n=162). Initiation of therapy and radiographic aggravation was compared between groups.Results Overall median observation time was 44.3 months (interquartile range, 28.0-70.2). Fewer non-sputum NTM-PD patients initiated treatment than sputum NTM-PD patients (p<0.001). Moreover, fewer non-sputum NTM-PD patients exhibited radiographic aggravation than sputum NTM-PD patients (p=0.001). Both time to radiographic aggravation and initiation of therapy were significantly shorter in the sputum NTM-PD group (log-rank test; p=0.011 and p<0.001, respectively). Sputum NTM-PD patients showed higher initiation of therapy (aHR, 1.38; 95% CI, 1.02-1.87) and risk of radiographic aggravation (aHR, 1.47; 95% CI, 1.02-2.10) than non-sputum NTM-PD patients.Conclusion Prognosis of NTM-PD patients diagnosed with a non-sputum culture was better than that of NTM-PD patients diagnosed with a sputum culture. The disease course may differ depending on the diagnostic method.

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“…16 Studies show that in patients with MAC pulmonary disease, cultures from bronchial lavages have a greater sensitivity than sputum cultures; positive cultures were present in 93.8% and 50% of bronchial washings compared to 64.3% and 23.1% of sputum samples, respectively. 74,75 In suspected cases of LWS with three negative sputum samples, bronchoscopy with bronchial washings may be needed to confirm the diagnosis. Recently, polymerase chain reaction (PCR) and serodiagnostic tests have been utilized for rapid diagnosis.…”

Section: Pathogenesismentioning

confidence: 99%

Lady Windermere syndrome

Kumfer

Edriss

2017

The Chronicles

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Usefulness of bronchial lavage for the diagnosis of pulmonary disease caused by Mycobacterium avium-intracellulare complex (MAC) infection

Cited by 57 publications

References 11 publications

Limited value of transbronchial lung biopsy for diagnosing Mycobacterium avium complex lung disease

Limited value of transbronchial lung biopsy for diagnosing Mycobacterium avium complex lung disease

Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis

Lady Windermere syndrome

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