Usefulness of brain natriuretic peptide as a marker for separating cardiac and noncardiac causes of syncope

Tanimoto, Kojiro; Yukiiri, Kazushi; Mizushige, Katsufumi; Takagi, Yuichiro; Masugata, Hisashi; Shinomiya, Kaori; Hosomi, Naohisa; Takahashi, Tsutomu; Ohmori, Koji; Kohno, Masakazu

doi:10.1016/j.amjcard.2003.09.048

Cited by 42 publications

(31 citation statements)

References 7 publications

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“…They showed that BNP concentrations greater than 40 pg/ml allow the identification of cardiac syncope with 82 % sensitivity and 92 % specificity [17].…”

Section: Discussionmentioning

confidence: 98%

The role of NT-proBNP in the diagnostics and differentiation of cardiac and reflex syncope in adults: relative importance to clinical presentation and medical examinations

Stryjewski¹,

Nessler

Kuczaj

et al. 2014

J Interv Card Electrophysiol

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“…They showed that BNP concentrations greater than 40 pg/ml allow the identification of cardiac syncope with 82 % sensitivity and 92 % specificity [17].…”

Section: Discussionmentioning

confidence: 98%

The role of NT-proBNP in the diagnostics and differentiation of cardiac and reflex syncope in adults: relative importance to clinical presentation and medical examinations

Stryjewski¹,

Nessler

Kuczaj

et al. 2014

J Interv Card Electrophysiol

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“…Previously, BNP at a cutoff value of 40 pg/ml has been shown to be a marker for separating cardiac and noncardiac causes of syncope with high sensitivity and specificity (82% and 92%, respectively) (19). However, the findings reported by Reed et al (12) go 1 step further, inasmuch as this observation suggests that BNP Ն300 pg/ml was a strong predictor of serious events during follow-up (odds ratio: Ͼ7) and, in particular, cardiovascular death.…”

Section: See Page 713mentioning

confidence: 99%

Initial Evaluation of “Syncope and Collapse”

Benditt

Can

2010

Journal of the American College of Cardiology

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“…In a study by Tanimoto et al [35], the feasibility of using BNP measurements in a screening test for cardiac causes of syncope was investigated retrospectively in 118 patients. BNP concentrations in the group identified as having syncope of cardiac origin (118 + − 42 pg/ml, n = 61) were significantly higher than in the reflex-mediated (18 + − 7 pg/ml, n = 20), neurological (26 + − 13 pg/ml, n = 8) and unknown (28 + − 12 pg/ml, n = 29) groups.…”

Section: Syncope Of Cardiac Originmentioning

confidence: 99%

Cardiac natriuretic peptides for cardiac health

Rademaker¹,

Richards²

2004

Clinical Science

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The cardiac natriuretic peptides, ANP (atrial natriuretic peptide) and BNP (brain natriuretic peptide), are secreted by the heart in proportion to cardiac transmural pressures. They possess a wide range of effects in multiple tissues facilitating overall pressure/volume homoeostasis. The close relationship between plasma concentrations of these peptides and 'cardiac load' has led to their use as biomarkers of cardiac health with diagnostic and prognostic applications in a variety of disorders affecting the cardiovascular system. BNP and its N-terminal fragment (NT-BNP) are especially sensitive indicators of cardiac dysfunction and remodelling, and correlate strongly with severity. Given that cardiac ischaemia is also an important trigger for the release of these ventricular peptides, they may likewise play a role in the detection of coronary artery disease. Measurement of BNP/NT-BNP shows particular promise as a 'rule out' test for suspected cases of HF (heart failure) in both emergency care and outpatient settings, and may assist in identifying individuals with asymptomatic ventricular impairment who will benefit from therapy preventing progression to overt HF. The BNP peptides also predict subsequent haemodynamic deterioration and adverse events in cardiovascular disease, and can therefore be used to monitor those at high risk and act as a guide to optimization of treatment. The favourable biological properties of the natriuretic peptides have also led to their use as therapeutic agents.

show abstract

Usefulness of brain natriuretic peptide as a marker for separating cardiac and noncardiac causes of syncope

Cited by 42 publications

References 7 publications

The role of NT-proBNP in the diagnostics and differentiation of cardiac and reflex syncope in adults: relative importance to clinical presentation and medical examinations

The role of NT-proBNP in the diagnostics and differentiation of cardiac and reflex syncope in adults: relative importance to clinical presentation and medical examinations

Initial Evaluation of “Syncope and Collapse”

Cardiac natriuretic peptides for cardiac health

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