Usefulness of Bedside Testing for Brain Natriuretic Peptide to Identify Right Ventricular Dysfunction and Outcome in Normotensive Patients With Acute Pulmonary Embolism

Pieralli, Filippo; Olivotto, Iacopo; Vanni, Simone; Conti, Alberto; Camaiti, Alberto; Targioni, Giacomo; Grifoni, Stefano; Bèrni, G

doi:10.1016/j.amjcard.2005.11.075

Cited by 127 publications

(89 citation statements)

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“…32) Moreover, in the state of pulmonary embolism, BNP levels were reported to be valuable in predicting right ventricular function. 33,34) The major findings of the current study that the basal NT-proBNP levels were correlated with systolic pulmonary artery pressure and functional class and that the decrease in pulmonary artery pressure after PBMV was the only factor that correlated with the decrease in NT-proBNP is in line with the studies on pulmonary hypertension and BNP. On the basis of these findings, we conclude that NT-proBNP measurement may be used as an indicator of clinical status in patients with MS and may be valuable in identifying patients complicated with pulmonary hypertension.…”

Section: Discussionsupporting

confidence: 77%

“…The patient and control groups did not differ in terms of age (P = 0.722) [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] mm) dimensions were significantly higher in patients with MS (all P < 0.001). No significant difference was detected between the groups regarding left ventricular end-diastolic diameter (P = 0.795), left ventricular end-systolic diameter (P = 0.110), and ejection fraction (P = 0.156).…”

Section: Preprocedural Clinical and Morphologic Variables And Plasma mentioning

confidence: 99%

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The Effect of Percutaneous Balloon Mitral Valvuloplasty on N-Terminal- Pro B- Type Natriuretic Peptide Plasma Levels in Mitral Stenosis

Selçuk

Maden

et al. 2007

Int. Heart J.

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SUMMARYThe objectives of this study were to assess the effect of percutaneous mitral balloon valvuloplasty (PBMV) on the plasma levels of N-terminal-pro B-type natriuretic peptide (NT-proBNP) in patients with mitral stenosis (MS) and to investigate the relationship between the changes in hemodynamic variables and NT-proBNP levels after PBMV. Plasma NT-proBNP concentrations were obtained from 60 symptomatic patients with rheumatic MS who underwent PBMV, and in 35 age-and gender-matched healthy volunteers. Patients with MS were found to have significantly higher levels of plasma NTproBNP compared to the control group (293 [77-1093] pg/mL versus 24 [12-67] pg/mL, respectively; [P < 0.001]). The mean preprocedural NT-proBNP level fell significantly from 293 (77-1093) pg/mL to 214 (69-1028) pg/mL (P < 0.001) following PBMV. The percentage decrease in plasma NT-proBNP levels was correlated only with the percentage decrease in systolic pulmonary artery pressure (r = 0.687, P < 0.001) and this correlation persisted in linear regression analysis (β = -0.013; 95% CI [-0.018--0.008] and P < 0.001). However, NT-proBNP levels did not correlate with the percentage of improvement in NYHA functional class, mitral valve gradients, or left atrial pressure (all P > 0.05). These findings indicate that NT-proBNP measurement following PBMV may be valuable for evaluating changes in pulmonary artery pressure and that elevated NTproBNP levels in patients with MS may reflect the increased wall stress in the left atrium and right side of the heart. (Int Heart J 2007; 48: 579-590) Key words: Mitral balloon, NT-proBNP, Pulmonary hypertension BRAIN natriuretic peptide (BNP) is a member of the natriuretic peptide family that has regulatory and modulatory roles in the cardiovascular system 1) including natriuresis, diuresis, and vasodilatation.

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Section: Discussionsupporting

confidence: 77%

Section: Preprocedural Clinical and Morphologic Variables And Plasma mentioning

confidence: 99%

The Effect of Percutaneous Balloon Mitral Valvuloplasty on N-Terminal- Pro B- Type Natriuretic Peptide Plasma Levels in Mitral Stenosis

Selçuk

Maden

et al. 2007

Int. Heart J.

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“…BNP and NT-proBNP have been shown to be associated with long-term outcome in stable PAH [15,16], and are useful biomarkers of RV dysfunction in patients with acute pulmonary embolism, in the setting of acute RV pressure overload [17,18]. This is the first study to test the prognostic significance of absolute value of BNP in the setting of acute right heart failure in decompensated PAH.…”

Section: Pulmonary Circulation and Pulmonary Vascular Disease B Sztrmentioning

confidence: 99%

Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension

Sztrymf¹,

Souza²,

Bertoletti³

et al. 2009

European Respiratory Journal

230

209

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Acute right ventricular failure in the setting of pulmonary arterial hypertension (PAH) often requires hospitalisation in intensive care units (ICU) to manage the subsequent low cardiac output and its consequences. There are very few data on these acute events.We recorded demographic, clinical and biological data and therapy in consecutive patients suffering from acute right heart failure requiring catecholamine treatment in the ICU of the French referral centre for pulmonary hypertension. These variables were analysed according to the survival status in ICU.46 patients were included, the mean age was 50.3 yrs. ICU mortality was 41%. We found no difference in terms of demographics, clinical data, last haemodynamic measurements at admission. Systemic arterial pressure was significantly lower in the subgroup of patients whose clinical course was fatal. Plasma brain natriuretic peptide (BNP), C-reactive protein (CRP), serum sodium and creatinine at admission correlated with survival. Demonstration of an infection during the ICU stay was associated with a worse prognosis.These preliminary results underline the importance of some simple clinical and biological parameters in the prognostic evaluation of acute heart failure in the setting of PAH. Whether these parameters can guide therapy needs to be further investigated.

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“…Various studies examined the role of either BNP or NT-pro BNP in the risk stratification of patients with PTE [1][2][3][4][5][6] . The relationship between BNP increase in acute pulmonary embolism and the increase in mortality and morbidity is very well known; however, the role of tenascin-C in patients with acute PTE is not known.…”

Section: Introductionmentioning

confidence: 99%

Tenascin-C May Be a Predictor of Acute Pulmonary Thromboembolism

Çelik

Koçyiğit

Çalapkorur

et al. 2011

JAT

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Aim:Numerous studies have shown an increase in NT-pro BNP, troponin and D-dimer levels with right ventricular dysfunction on echocardiography in patients with acute pulmonary thromboembolism (PTE). We found no data about the relation between tenascin-C and acute PTE in the literature. The aim of this study was to evaluate tenascin-C levels in acute PTE and correlate them with NT-pro BNP, troponin and D-dimer. Method: Thirty-four patients who have massive or submassive PTE on spiral thorax CT (PTE group) and twenty healthy volunteers (non-PTE group) were evaluated. In all patients, right ventricular functions were obtained on transthoracic echocardiography and plasma tenascin-C, NT-pro BNP, troponin , and D-dimer levels were measured. Results: The left ventricular systolic diameter, left ventricular diastolic diameter and left ventricular ejection fraction were similar in the two groups. The right heart chamber sizes and main pulmonary artery diameter were significantly larger in the PTE group and systolic pulmonary artery pressures were also significantly higher in this group. Tenascin-C, NT-pro BNP, and D-dimer levels were also significantly higher in the PTE group than in the non-PTE group ( p 0.001). The troponin I levels did not differ between the two groups ( p 0.4). Tenascin-C was found to be highly correlated with sPAP and NT-pro BNP and correlated with D-dimer; however, troponin I was not correlated with tenascin-C. Conclusion: This study demonstrates that tenascin-C may be an indicator of acute PTE. J Atheroscler Thromb, 2011; 18:487-493.

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Usefulness of Bedside Testing for Brain Natriuretic Peptide to Identify Right Ventricular Dysfunction and Outcome in Normotensive Patients With Acute Pulmonary Embolism

Cited by 127 publications

References 10 publications

The Effect of Percutaneous Balloon Mitral Valvuloplasty on N-Terminal- Pro B- Type Natriuretic Peptide Plasma Levels in Mitral Stenosis

The Effect of Percutaneous Balloon Mitral Valvuloplasty on N-Terminal- Pro B- Type Natriuretic Peptide Plasma Levels in Mitral Stenosis

Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension

Tenascin-C May Be a Predictor of Acute Pulmonary Thromboembolism

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