Usefulness of automated cell counter in detection of malaria in a cancer set up-Our experience

Jain, Monica; Gupta, Surbhi; Jain, Jyotika; Grover, Rajesh K.

doi:10.4103/0377-4929.107782

Cited by 22 publications

(23 citation statements)

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“…In our study, WBC scattergrams showed lower sensitivity and PPV in P.falciparum detection similar to studies conducted by Jain et al [12] and Zuluaga et al 13 This could also be attributed to the low number of P. falciparum cases in the current study as P.vivax is the dominant malarial parasite in this part of the country 16. However, larger studies from P.falciparum predominant areas are required to further comment on the usefulness of analyzers in diagnosis of the same.…”

Section: Discussionsupporting

confidence: 91%

Automated Hematology Analyzers in Diagnosis of Plasmodium Vivax Malaria: An Adjunct to Conventional Microscopy.

Hasaf

Devadass

Aarathi

et al. 2014

Mediterr J Hematol Infect Dis

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Malaria is one of the most pervasive parasitic diseases ever known to mankind affecting nearly 300 million people every year. The need for rapid diagnosis of malaria in tropical and subtropical malaria endemic areas is on the rise. In this study, we evaluated the usefulness of hematology autoanalyzers, Sysmex XE-2100 & XT-2000i in the presumptive diagnosis of malaria. Our study shows that abnormalities in WBC/BASO scattergram when combined with presence of thrombocytopenia had a high sensitivity and positive predictive value in the presumptive diagnosis of Plasmodium vivax (P.vivax) malaria.

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Section: Discussionsupporting

confidence: 91%

Automated Hematology Analyzers in Diagnosis of Plasmodium Vivax Malaria: An Adjunct to Conventional Microscopy.

Hasaf

Devadass

Aarathi

et al. 2014

Mediterr J Hematol Infect Dis

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“…[3][4][5][6][7][8] However, in a tropical nation where infectious diseases such as malaria and dengue pose a greater public health burden, the utility of the WBC flags in hinting toward an underlying infection is poorly understood and scarcely documented in the literature. [9][10][11][12] We undertook this study to analyze any abnormal flags generated by a three-part automated hematology analyzer in serologically confirmed cases of dengue and correlate with other hematological parameters and PBF findings in these patients.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

J Lab Physicians

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BACKGROUND: Automated hematology analyzers often generate many flags which can provide important clues to the underlying hematological abnormality. Although pathologists are generally well versed in recognizing the importance of flags indicating potential leukemic blasts, their utility in hinting toward infectious etiology, especially during epidemics, is less well known. We analyzed any abnormal flags generated by a three-part automated hematology analyzer in serologically confirmed cases of dengue. MATERIALS AND METHODS: The study included 28 patients diagnosed with serologically confirmed dengue infection. The venous samples were run on ABX Miros-60 three-part hematology analyzer. The complete blood count data and any abnormal flags were noted and correlated with peripheral blood film findings in all patients. RESULTS: An abnormal white blood cell (WBC) flag was noted in all 28 patients, including two in whom all other hematological parameters were within normal limits. In 26 (93%) patients, M2G1G2 WBC flag was noted while the samples of the remaining two patients generated M2G1 and L1M2G1G2 WBC flags, respectively. CONCLUSION: An abnormal WBC flag, when correlated in appropriate clinical context, especially during a dengue outbreak, can aid in targeting the cohort of patients who will require immediate referral for serological confirmation.

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“…The following findings are included in the DIFF Channel. [3][4][5] 1. Fusion of populations of eosinophils and neutrophils, which may be red, sky blue or gray.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the described patterns are more sensitive to detect P. vivax, than P. falciparum and other species. 5,6 The patterns described are not related to the parasitic index but to the presence of trophozoites, schizonts or ring forms. A higher number of mature trophozoites and schizonts correlates with anomalies in the DIFF channel.…”

Section: In the Wbc / Baso Channel Events Highlighted In Blue In Thementioning

confidence: 95%

“…A higher number of mature trophozoites and schizonts correlates with anomalies in the DIFF channel. [4][5][6] In other studies, the sensitivity of the method has been subject to the number of young parasites in circulation, the severity of the infection and the patient's immune response, which limits the production of hemozoin staying below the detectable limits of the analyzer. 4 In the case described, despite having low parasitic density, the presence of mature trophozoites and schizonts could make perceptible the finding in the hematological analyzer.…”

Section: In the Wbc / Baso Channel Events Highlighted In Blue In Thementioning

confidence: 99%

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Diagnosis and follow-up of a Plasmodium vivax malaria case through the Sysmex XT-1800i® hematology analyzer

Fallas-Mora¹,

Cordero-Montero²,

Sánchez-Barahona³

et al. 2019

IJMBOA

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Malaria is one of the most important parasitic diseases in the world. It is caused by parasites of the genus Plasmodium sp., which enter humans through the bite of mosquitoes of the genus Anopheles. Automated hematology analyzers based on flow cytometry have been widely used to aid in the diagnosis of malaria, based on the existence of alterations in the scatter plots that suggest the presence of parasites of the genus Plasmodium. The case of a 55-year-old male patient is presented, worker from a Costa Rican rural zone, correlating the alterations in channel DIFF and WBC/BASO of the Sysmex XT-1800i® hematological analyzer with what was found in the thick drop. The objective of this case report is to demonstrate the utility of hematological analyzers in the detection of relapses, reinfections and follow-up in patients diagnosed with malaria.

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Usefulness of automated cell counter in detection of malaria in a cancer set up-Our experience

Cited by 22 publications

References 0 publications

Automated Hematology Analyzers in Diagnosis of Plasmodium Vivax Malaria: An Adjunct to Conventional Microscopy.

Automated Hematology Analyzers in Diagnosis of Plasmodium Vivax Malaria: An Adjunct to Conventional Microscopy.

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Diagnosis and follow-up of a Plasmodium vivax malaria case through the Sysmex XT-1800i® hematology analyzer

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