Usefulness of Atherogenic Dyslipidemia for Predicting Cardiovascular Risk in Patients With Angiographically Defined Coronary Artery Disease

Arca, Marcello; Mestice, Anna; Valiante, Sofia; Campagna, F.; Pigna, Giovanni; Paoletti, Vincenzo; Antonini, R; Barillà, Francesco; Tanzilli, Gaetano; Vestri, Annarita; Gaudio, Carlo

doi:10.1016/j.amjcard.2007.06.049

Cited by 66 publications

(47 citation statements)

References 21 publications

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“…Atherogenic dyslipidemia is a risk factor for heart disease [29]. Four of the participants in the HND diet case series (ID = 2, 3, 6, 12) had atherogenic dyslipidemia, which are triglycerides > 200 mg/dl and HDL < 50 mg/dl for a female or < 40 mg/dl for a male.…”

Section: Discussionmentioning

confidence: 99%

Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet

Dunaief¹,

Fuhrman²,

Dunaief³

et al. 2012

OJPM

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Objective: The purpose of this study was to provide an initial assessment of the effectiveness of the high nutrient density (HND) diet on glycemic control and cardiovascular risk factors in participants with type 2 diabetes. Design: This was a retrospective case series study. Participants were 13 adult type 2 diabetic U.S. women and men between the ages of 30 -80 years old. Glycosylated hemoglobin (HbA1C), lipid profile, blood pressure, BMI, and medication requirements before and after commencement of the HND diet were compared. Results: After a median length on the HND diet of 7 months, the mean HbA1C dropped from 8.2% to 5.8% (p = 0.002), with sixty-two percent of participants reaching normoglycemic levels (HbA1C < 6.0%). There was a substantial reduction in mean blood pressure for hypertensive participants (n=10) from a pre-intervention level of 148/87 mmHg to 121/74 mmHg (p = 0.0004 for systolic blood pressure, p = 0.01 for diastolic blood pressure). Triglycerides significantly decreased from a mean of 171 mg/dl to a mean of 103 mg/dl (p = 0.02). The mean HDL increased significantly from 48.3 mg/dl to 54.6 mg/dl (p = 0.03). The mean number of medications dropped from 4 to 1 (p = 0.0006). Conclusions: The HND diet was very effective in controlling glycemic levels and cardiovascular risk factors in 13 participants with type 2 diabetes. Therefore, there is a well-justified need for further study with the HND diet.

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Section: Discussionmentioning

confidence: 99%

Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet

Dunaief¹,

Fuhrman²,

Dunaief³

et al. 2012

OJPM

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“…TRL fractions d < 1.019 g/ml (chylomicrons, VLDLs, and remnants) were obtained by sequential ultracentrifugation, as indicated elsewhere (31). Major lipoprotein classes were also separated by fast-performance liquid chromatography (FPLC), as previously described (18).…”

Section: Laboratory Measurementsmentioning

confidence: 99%

Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism

Minicocci

Tikka

Poggiogalle

et al. 2016

Journal of Lipid Research

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“…A cohort of 530 consecutive patients selected based on the angiographic evidence of coronary atherosclerosis (1 or more stenoses >50% in at least 1 epicardial vessel) was enrolled between December 1993 and August 1997 [3]. Patients underwent coronary angiography due to myocardial infarction (MI) (n = 220) and/or angina pectoris (n = 310), and were enrolled 3 months after the acute coronary event.…”

Section: Methodsmentioning

confidence: 99%

“…Blood samples were also obtained from patients at entry. Traditional risk factors were diagnosed as previously described [3]. …”

Section: Methodsmentioning

confidence: 99%

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Functional rs20417 SNP (–765G>C) of Cyclooxygenase-2 Gene Does Not Predict the Risk of Recurrence of Ischemic Events in Coronary Patients: Results of a 7-Year Prospective Study

Mestice

Barillà²,

Tanzilli³

et al. 2010

Cardiology

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Objectives: The –765G>C variation (rs20417 SNP) in the promoter of cyclooxygenase-2 (COX-2) gene has been demonstrated to lower COX-2 enzyme activity in the vasculature, thus affecting atherosclerotic plaque growth and stability. Therefore, this genetic variant may be a candidate influencing the residual risk. Methods: In 285 coronary patients the incidence of major adverse cardiovascular events (MACEs), defined as a composite of cardiovascular deaths, non-fatal myocardial infarction and stroke, unstable angina and revascularization procedures, was monitored for a median of 7.8 years. The genotypes were obtained in 231 patients (81%) by PCR amplification and FAU I digestion. Results: 89 MACEs (38.5%) were recorded during the follow-up in genotyped patients. Their incidence was not different in patients with GC or CC when compared with those with GG genotype (46.2 vs. 35.5% respectively; p = 0.14). Kaplan-Meyer analysis did not demonstrate any influence of COX-2 genotypes on the event-free survival time (log-rank p = 0.55). After controlling for confounders, the –765G>C carrier status was not associated with significant variation in the risk of MACE or its individual components. Conclusions: These results suggest that the functional G–765C variant in the COX-2 gene is not a significant predictor of the recurrence of ischemic events in coronary patients.

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Usefulness of Atherogenic Dyslipidemia for Predicting Cardiovascular Risk in Patients With Angiographically Defined Coronary Artery Disease

Cited by 66 publications

References 21 publications

Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet

Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet

Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism

Functional rs20417 SNP (–765G>C) of Cyclooxygenase-2 Gene Does Not Predict the Risk of Recurrence of Ischemic Events in Coronary Patients: Results of a 7-Year Prospective Study

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