Usefulness of Argyrophilic Nucleolar Organizer Staining for Predicting Prognosis of Patients with Recurrent Soft Tissue Sarcoma

Kuratsu, Shigeyuki; Ohsawa, Masahiko; Naka, Norifumi; Myoui, Akira; Tomita, Yashuiko; Uchida, Atsushi; Ono, Katsuhiko; Aozasa, Katsuyuki

doi:10.1159/000227343

Cited by 8 publications

(8 citation statements)

References 9 publications

(9 reference statements)

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“…The validity of clinicopathologic and molecular genetic variables in predicting outcome of SS is still under evaluation. Among other parameters, primary tumor size, margin of resection, mean mitotic activity, DNA ploidy, and proliferative index have been proposed as prognostic factors for survival in SS 27, 42–44…”

Section: Discussionmentioning

confidence: 99%

Primary pleuropulmonary synovial sarcoma

Essary

Vargas

Fletcher

2002

Cancer

136

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BACKGROUNDPrimary pleuropulmonary synovial sarcoma (SS) is a rare neoplasm and a recently recognized anatomic subset. Its clinicopathologic attributes are not yet well defined.METHODSIn this study, the clinical and histopathologic features of 12 SS arising in the lung and/ or pleura were analyzed.RESULTSThe neoplasms occurred in 7 men and 5 women, 20–72 years old (median, 31 years), were well circumscribed with a mean size of 7.2 cm, and involved either lung (9 cases), pleura (2 cases), or both (1 case). All the tumors were of monophasic type. Nine showed a classic spindle cell pattern, and three showed predominantly poorly differentiated features. All but one case showed at least focal positivity for epithelial membrane antigen (EMA), a finding characteristic of this tumor. The lack of EMA staining in one case, proven by electron microscopy to be SS, was attributed to the scarcity of material available for immunohistochemical stains. The diagnosis was proven cytogenetically in three cases. Within 2 years, local recurrence developed in 8 patients (75%), 3 of whom developed metastasis (25%). Five patients died of their disease within 2.5 years, 4 of them from uncontrolled local disease.CONCLUSIONSThe authors conclude that pleuropulmonary SS, although rare, represents a distinct anatomic subset having pathologic features similar to those of its soft tissue counterpart. Its clinical behavior appears more aggressive, perhaps because of relatively later presentation combined with the difficulty in obtaining a wide surgical margin. Cancer 2002;94:459–69. © 2002 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Primary pleuropulmonary synovial sarcoma

Essary

Vargas

Fletcher

2002

Cancer

136

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“…The retroperitoneum is an adverse site of origin with a 5-year survival rate of only 14% probably due to late diagnosis and difficult surgical accessibility [1,6,9,10]. Local recurrence may be accompanied by an increased malignant potential and is considered to be a risk marker for distant failure [4,11,12]. Cases 1 and 2 shared almost all the adverse prognostic criteria recently established in a multicenter series of 216 patients [1]: age older than 50 years; tumor size 18 cm, and a deeply invading high-grade nonmyxoid tumor.…”

Section: Discussionmentioning

confidence: 99%

Locally Recurrent Malignant Fibrous Histiocytoma: A Rare and Aggressive Genitourinary Malignancy

Froehner

Manseck²,

Haase³

et al. 1999

Urol Int

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Objective: In this study, 22 cases of locally recurrent urological malignant fibrous histiocytoma were reviewed considering therapeutic options, follow-up and prognosis. Patients and Methods: In the available literature on this topic we identified 19 cases of locally recurrent genitourinary malignant fibrous histiocytoma. Three additional cases are discussed, primarily arising from the kidney, the bladder and the paratesticular region. Results: The prognosis of locally recurrent urological malignant fibrous histiocytoma was found to be extraordinarily poor. Only 2 of 22 patients have survived for longer than 3.5 years. One of them reported herein is still alive 10 years after extensive lymphatic spread accompanying the first local recurrence. In this case, late local recurrence occurred after an 8-year interval free of disease. Conclusion: Malignant fibrous histiocytoma is an unusual urological malignancy with a high rate of local recurrence. The latter is frequently accompanied by metastatic disease and unrelenting progression. Despite the poor prognosis early detection of local failure and aggressive salvage therapy might offer the chance of long-term survival in selected cases. Close and life-long follow-up is advisable for patients once treated for recurrent urological malignant fibrous histiocytoma.

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“…In other studies on bone and soft tissue tumors, the relationship of various growth indices to prognosis has been examined: those were labeling rates with BrdU [10,11], Ki-67 [30], PCNA [2,3] and argyrophilic nucleolar organizer region (AgNOR) [12,13,28], mast cell count in tumors [29], and DNA ploidy pattern [14]. Retrospective studies reported close correlation of AgNOR, Ki-67, DNA ploidy pattern and mast cell count with prognosis and malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…No reflection of heterogeneity that is a characteristic of bone and soft tissue tumors is also a demerit of this method. AgNOR has been reported to be useful as a prognostic indicator [12,13,28]. Although a merit of AgNOR is possible treatment of many tumor tissues, the function of AgNOR itself is not clarified yet and theoretical background is obscure even though empirically right.…”

Section: Discussionmentioning

confidence: 99%